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  • 1
    Electronic Resource
    Electronic Resource
    A comparative study on antibodies to nucleoli and 5-hydroxytryptamine in patients with fibromyalgia syndrome and tryptophan-induced eosinophilia-myalgia syndrome (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 541-549 
    Details
    ISSN: 1432-1440
    Keywords: Eosinophilia myalgia syndrome ; Fibromyalgia syndrome ; Anti-serotonin antibodies ; Anti-ganglioside antibodies ; Anti-phospholipid antibodies ; Anti-nucleolar antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eosinophilia myalgia syndrome (EMS) has been related to intake of “contaminated” L-tryptophan, and an alteration in tryptophan 5-hydroxytryptamine (5-HT, serotonin) metabolism has been reported in EMS patients. Recently we found that a defined autoantibody pattern consisting of antibodies to nucleoli, gangliosides, and phospholipids is closely related to the fibromyalgia syndrome (FS) which clinically resembles the EMS. We were therefore interested to see whether these antibodies can also be detected in patients with EMS. Studied were 27 patients with acute EMS (13 of whom were also examined 2 years after acute onset), 100 patients with FS, and 40 patients with progressive systemic sclerosis (PSS). As controls, sera from 100 blood donors were analyzed. Antibodies to nucleoli were demonstrated by immunofluorescence test on cell cultures in 52% of patients with acute EMS, 62% of patients with chronic EMS, and 37% of FS patients. Western blotting with a nuclear extract from HeLa cells revealed in both diseases the same epitopes at 63, 57, and 53 kDa. Antibodies to 5-HT, gangliosides (Gm1), and phospholipids were determined by enzyme-linked immunosorbent assay. Among patients with FS 73% had antibodies to 5-HT, in contrast to only 19% of patients with acute EMS. However, 77% of the 13 EMS patients analyzed 2 years later had become anti-5-HT antibody positive during that time. Also the incidence of antibodies to Gm1 increased from 37% at acute onset to 69% in patients with chronic EMS (30%). The various antibodies were detected in only 18% of healthy controls. Serum 5-HT levels were decreased in patients with acute EMS compared to those with chronic EMS or FS. In patients with PSS they were significantly increased. It is concluded that EMS may have been developed in patients with FS who may have reacted in an allergic manner to a more immunogenic (“contaminated”) L-tryptophan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00207485
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  • 2
    Electronic Resource
    Electronic Resource
    Experimental heats of mixing for gaseous nitrogen and methane (1971)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 17 (1971), S. 958-965 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The excess enthalpy of binary gas phase mixtures has been measured by direct experiment, using a continuous flow, isothermal colorimeter. Heat of mixing data are presented for the methane-nitrogen system for compositions of 25 to 80 mole % methane in nitrogen, at temperatures of 40°, 0°, -20°, -40°, -60°, and -78°C. and pressures from 250 to 1,50 lb./sq. in. abs. These data are in agreement with the literature to within the experimental uncertainty of this work, 4%.The experimental results agree well with values predicted using the Benedict-Webb-Rubin and the Redlich-Kwong equations of state. The virial equation of state truncated after the third coefficient fits the low density data only. The liquid theories of Scott predict the enthalpies of the mixtures in a qualitative way.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690170432
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  • 3
    Electronic Resource
    Electronic Resource
    A randomised double-blind 16-week study of ritanserin in fibromyalgia syndrome: Clinical outcome and analysis of autoantibodies to serotonin, gangliosides and phospholipids (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 89-94 
    Details
    ISSN: 1434-9949
    Keywords: Anti-ganglioside antibodies ; Anti-phospholipid antibodies ; Anti-serotonin antibodies ; Fibromyalgia syndrome ; 5-HT-receptor blocker ; Ritanserin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the study was to evaluate in a double-blind manner the effect of the long-acting 5-hydroxytryptamine 2 (5-HT2)-receptor blocker Ritanserin on clinical symptoms in patients with fibromyalgia syndrome (FM) and on production of antibodies to serotonin, gangliosides and phospholipids, recently shown to have a high incidence in this disease. Fifty-one female patients with typical FM were included in the 16-week study: 24 received Ritanserin and 27 received a placebo. Antibodies to 5-HT, gangliosides (Gm1) and phospholipids (thromboplastin) were determined by enzyme-linked immunosorbent assay at day 0 and at the end of week 16. The psychological and physical status, including tender points, of the patients was evaluated at day 0 and at the end of weeks 4 and 16. At the end of the study, there was an improvement (p〈0.05) in feeling refreshed in the morning in the Ritanserin-treated group and headache was also significantly improved compared with the placebo group. There was no difference in pain, fatigue, sleep, morning stiffness, anxiety and tender point counts in the Ritanserin and placebo groups. Fifty-one per cent of the 51 patients had at least one of the three antibodies to 5-HT, Gm1 and phospholipids. The incidence and activity of these antibodies were not influenced by Ritanserin or placebo. The observation that Ritanserin has only a small effect on clinical symptoms indicates that disturbances in serotonin metabolism or uptake may be only one factor in the pathogenesis of the disease. The high incidence of a defined autoantibody pattern in FM could again be confirmed in this study. However, it remains speculative whether immunological reactions are, indeed, involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01452251
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  • 4
    Electronic Resource
    Electronic Resource
    Die Temperaturabhängigkeit einiger elastischer Eigenschaften im Erweichungsintervall der Gläser (1930)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 192 (1930), S. 161-178 
    Details
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19301920112
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  • 5
    Electronic Resource
    Electronic Resource
    Fatigue crack propagation behavior of ultra high molecular weight polyethylene under mixed mode conditions (1994)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 28 (1994), S. 181-187 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Analytical studies of the stresses on and within ultra high molecular weight polyethylene joint components suggest that damage modes associated with polyethylene fatigue failure are caused by a combination of surface and subsurface crack propagation. Fatigue crack propagation tests under mixed mode loading conditions were conducted on center-cracked tension specimens machined from extruded blocks of sterilized polyethylene in an attempt to determine how fatigue cracks change direction in this material. Cyclic testing was performed using a sinusoidal wave form at a frequency of 5 Hz and an R-ratio (minimum load/ maximum load) of 0.15. Specimens had the notch oriented perpendicular to the direction of applied load and at angles of 60° and 45° to the loading direction. Numerical analyses were used to interpret the experimental test and to predict the fatigue behavior of polyethylene under mixed mode conditions. It was found that all cracks eventually propagated horizontally, regardless of the initial angle of inclination of the notch to the direction of applied cyclic load. In fact, the extent of the curvilinear crack growth was quite limited. An effective range of cyclic stress intensity factor was calculated for correlation with the rate of crack growth. The results followed a Paris relation, with crack growth rate linearly related to a power of the range of stress intensity, for all three crack orientations. The numerical analyses adequately modeled the experimental fatigue crack growth results. © 1994 John Wiley & Sons, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820280207
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  • 6
    Electronic Resource
    Electronic Resource
    Ein verbessertes Huygens-Manometer (1951)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 23 (1951), S. 564-565 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Beim einseitig geschlossenen Huygens-Manometer konnte bisher keine lineare Abhängigkeit zwischen Druck- und Skalenteilen erreicht werden. Durch Anbringen eines Birnengeräßes am Kapillarende wurde das Manometer soweit verbessert, daß man eine völlig lineare Eichkurve erhält.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330232303
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  • 7
    Electronic Resource
    Electronic Resource
    The structure of thialene as studied by proton magnetic resonance in a nematic phase (1985)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 23 (1985), S. 1045-1047 
    Details
    ISSN: 0749-1581
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1H NMR studies on thialene (cyclopenta[b]thiapyran) oriented in a nematic liquid crystalline phase are reported. The indirect spin-spin and direct dipolar couplings and the chemical shifts between the protons are derived from the spectral analysis. The intra-ring proton-proton indirect couplings derived from the isotropic and nematic phase spectra are in agreement. The inter-ring proton-proton couplings, however, could only be obtained from the nematic phase spectra. The structural information extracted from the direct dipolar couplings corresponds to significant distortions in the arrangement of the protons of the six- and five-membered rings from the regular hexagonal and pentagonal arrangements, respectively; the molecular geometry of the fused five-membered ring is similar to that of the corresponding ring in azulene.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260231206
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  • 8
    Electronic Resource
    Electronic Resource
    Über Isomerisationsprodukte der Pyridinsalze ungesättigter Säuren (1933)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 505 (1933), S. 307-310 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19335050122
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