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  • 1
    Electronic Resource
    Electronic Resource
    Complement-activating properties of IgM rheumatoid factors reacting with IgG subclasses (1995)
    Springer
    Clinical rheumatology 14 (1995), S. 425-428 
    Details
    ISSN: 1434-9949
    Keywords: IgM Rheumatoid Factor ; Complement Activation ; IgG Subclass ; Rheumatoid Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To estimate the complement-activating property (CAP) of IgM rheumatoid factor (RF), which was purified from synovial fluids of patients with rheumatoid arthritis, in a reaction with each IgG subclass, the activation and binding of C4 in the classical pathway of complement by IgM RF was measured in an enzyme-linked immunosorbent assay using biotinylated F(ab')2 antibody to human C4. The CAP of IgM RF reacting with IgG3 was significantly higher than that of IgM RFs bound to the other IgG subclasses (P〈0.01). These results suggest that IgM RF reacting with IgG3 in synovial fluid could induce a greater degree of complement-dependent inflammation in RA synovium than IgM RF reacting with other IgG subclasses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02207676
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pulmonary hypertension in MCTD: Report of two cases with anticardiolipin antibody (1992)
    Springer
    Clinical rheumatology 11 (1992), S. 195-201 
    Details
    ISSN: 1434-9949
    Keywords: Pulmonary Hypertension ; Anticardiolipin Antibody ; Mixed Connective Tissue Disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report on 2 patients with well-documented mixed connective tissue disease (MCTD) accompanied by severe pulmonary hypertension (PH) due to thrombosis or thromboembolism. In a previous report we indicated (1) that patients with MCTD complicated by PH have a significantly worse prognosis than patients with other connective tissue disease (CTD) complicated by PH. Both our patients had anticardiolipin antibody (a-CL) in the initial stages of the disease. We also studied the relationship of a-CL to PH in patients with other CTD. Patients of either MCTD or SLE with high levels of a-CL had significantly higher values of mean pulmonary arterial pressure than patients without a-CL. Several factors were suggested for the pathogenesis of PH such as vasospasm, arteritis, platelet dysfunction, and thrombosis or thromboembolism. The presence of a-CL may be one of important factors in development of PH among patients with MCTD with recurrent pulmonary thrombosis or thromboembolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02207956
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    An autopsy case with Good's syndrome and dermatomyositis (1985)
    Springer
    Clinical rheumatology 4 (1985), S. 196-201 
    Details
    ISSN: 1434-9949
    Keywords: Good's Syndrome ; Dermatomyositis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 31-year-old male patient complaining of repeated respiratory infections was revealed to be in an immunodeficient state in both humoral and cellular immunity and accompanied by dermatomyositis which was proved by both clinical and histological findings. Persistent diarrhea followed by colonic bleeding due to multiple ulcers and a severe liver dysfunction seemed to bring him to his death. The autopsy revealed the presence of thymoma of spindel cell type, depleted cells in the systemic lymphatic systems and inflammatory lesions in the muscle, liver, lung, kidney and gastrointestinal tract. This is the first report of Good's syndrome accompanied by dermatomyositis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032294
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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