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  • Chlordiazepoxide  (3)
  • Anticholinergics  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Chlordiazepoxide modified exploration in rats (1972)
    Springer
    Psychopharmacology 24 (1972), S. 462-469 
    Details
    ISSN: 1432-2072
    Keywords: Chlordiazepoxide ; Exploration ; Locomotion ; Rearing ; Novelty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Effects of 2.5, 3.75 and 5.0 mg/kg chlordiazepoxide on locomotion, rearing and preferences for novelty in rats were observed in an exploration box comprising a novel and a familiar half. Whereas an inverted U relationship between dose strength and locomotion was evident, rearing declined with increasing dosage. However, the two lower doses had little effect on preferences for novelty but 5.0 mg/kg produced a marked decrease to the point where the familiar half of the apparatus was preferred. It was concluded that estimates of drug effects on measures of locomotion or general activity are specific to those behaviours alone and do not necessarily relate to environmentally oriented exploration. Different views of the effects of drugs on exploratory behaviour might arise from the use of more valid indices, such as preferences for novelty.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00423436
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of scopolamine on performance on a geometric progressive ratio schedule (1974)
    Springer
    Psychopharmacology 38 (1974), S. 55-66 
    Details
    ISSN: 1432-2072
    Keywords: Scopolamine ; Anticholinergics ; Cholinergic Blockade ; Progressive Ratio ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to respond on a geometric progressive ratio schedule until performance was stable. They were then injected with the anticholinergic drug scopolamine at doses of 0.05, 0.1, 0.25, 1.0 and 2.0 mg/kg. Control animals were administered atropine methyl nitrate (1–20 mg/kg). Increasing doses of scopolamine typically produced first an increase, then a decrease in behavior compared with baseline levels, measured by total number of responses, total number of reinforcements, and final completed ratio, per session. Atropine methyl nitrate had no effect on the behaviour of the control animals. This indicates that the effects of scopolamine are due to its central action. The inverted-U dose-response curve found for scopolamine resembles that found for chlordiazepoxide, phenobarbital, and d-amphetamine on progressive schedules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421287
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The role of social isolation and sex in determining effects of chlordiazepoxide and methylphenidate on exploratory behaviour (1972)
    Springer
    Psychopharmacology 27 (1972), S. 359-366 
    Details
    ISSN: 1432-2072
    Keywords: Isolation ; Sex Differences ; Chlordiazepoxide ; Methylphenidate ; Exploration ; Locomotion ; Rearing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Effects of two doses each of chlordiazepoxide and methylphenidate on exploration, locomotion and rearing were observed in isolated and grouped male and female rats. Sex of the animals determined the effects of both drugs on rearing, and of chlordiazepoxide on preferences for the novel half of an exploration box. Drug administration seemed to abolish initial sex differences on the former response. Locomotion of isolated and grouped animals was also differentially affected by chlordiazepoxide. These findings emphasised the need to take genetic and environmental factors into account when considering the effects of psychotropic drugs on exploratory behaviour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429389
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Chlordiazepoxide effects on reactions to novelty and activity with and without prior drug experience (1975)
    Springer
    Psychopharmacology 42 (1975), S. 289-292 
    Details
    ISSN: 1432-2072
    Keywords: Chlordiazepoxide ; Drug Experience ; Rats ; Novelty ; Rearing ; Ambulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Reactions to novelty, rearing and ambulation were observed in rats following saline or chlordiazepoxide injections either with or without prior drug experience. Drug suppression of the former two response was evident but there was no indication of prior drug experience being effective. However, experience appeared to negate the compound's depressant effect on ambulation shown by inexperienced subjects. It was concluded that inhibitory influences of chlordiazepoxide on reactions to novelty and rearing can not be ascribed to the aversive effects of a novel drug state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421270
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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