ISSN:
1432-1440
Keywords:
Heparin
;
Low molecular weight heparin
;
Protamine chloride
;
Antidot
;
Factor XA
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Low molecular weight (LMW) heparin Kabi 2165 possesses improved pharmacodynamic properties compared with conventional heparin. It is currently investigated in the prophylaxis of thromboembolism. The neutralization of Kabi 2165 by protamine chloride was analysed after i.v. injection of both the agent and the antidot in healthy persons. The anticoagulant effects of the LMW heparin on the activated partial thromboplastin time, thrombin, and thromboelastography are completely and immediately suppressed by protamine chloride. The inhibition of factor X a is antagonized up to 50%–60%. The bleeding time remained unaffected. The data indicate that protamine chloride may be used in clinical situations as an antidot to the LMW heparin Kabi 2165. A rebound phenomenon of the anticoagulant effect does not occur.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01728455
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