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  • Organic Chemistry  (2)
  • Antigen and nucleic acid detection  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 63 (1985), S. 241-251 
    ISSN: 1432-1440
    Keywords: HCMV isolation ; Antigen and nucleic acid detection ; Ig class-specific antibody determination ; Risk groups: pregnancy, blood transfusion, organ transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cytomegalic inclusion disease (CID) is caused by a horizontally or vertically transmitted human herpes virus infection and may persist for life without obvious clinical symptoms. A serious course of horizontal primary and recurrent infections, however, is often observed in immunocompromised persons such as recipients of organ transplants and patients receiving fresh blood transfusions. Vertical infection may cause fetopathies. The human cytomegalovirus (HCMV) is thought to inherit an oncogenic potential as lately discussed for AIDS and M. Kaposi. Laboratory diagnosis of HCMV infection is performed by light microscopy (inclusion bodies), electron microscopy, virus isolation in cell culture, demonstration of viral DNA and antigen in clinical specimens, by histochemical methods (e.g. immunoperoxidase technique) and by DNA and peptide analysis for identification of different isolates and viral finger prints. Evaluation of cell-mediated immunity in HCMV infection is performed quantitatively (assessment of Thelper/Tsuppressor ratios) or qualitatively (specific lymphocyte stimulation by the antigen). In most cases laboratory diagnosis is achieved by serological methods, i.e. demonstration and quantitation of HCMV-specific antibodies. In this context, a number of liquid- and solid-phase immunoassays have been developed, of which immunofluorescence and ELISA are most commonly used, besides complement fixation and passive haemaglutination. These procedures on the one hand allow the use of different antigen preparations as early and late viral proteins, and on the other hand permit a specific determination of different Ig classes and subclasses. A variety of assays has been established especially for determination of virus-specific IgM antibodies, which are predominantly found in active infection. These, however, at least in part may show non-specific results caused by interference of rheumatoid factor or IgG competition. Such problems have now been dealt with and are avoided by IgG precipitation or IgM immunosorption (“μ-capture” technique). These recent methods allow an exact epidemiological identification of risk groups for CMV infection. Results from our laboratory revealed 13% HCMV-IgM positive patients among pregnant women, 16% IgM positive patients among renal transplant recipients, 4% igM positive cases in patients after cardiosurgery and 1.7% IgM positives among prostitutes. The prevalence of HCMV infection as indicated by specific IgG antibodies was 56%, 90%, 83%, and 90%, respectively. No IgM antibodies were found in haemophiliacs and healthy blood donours, which showed a prevalence of HCMV infection in 69% and 47% of tested serum samples.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Coordintion Chemistry of Ethynes, II1). Indeno-indenes from Transition-Metal-Complexes of 1.2-Bis-phenylethinyl-benzeneAs well as with PdCl2, 1.2-Bis-phenylethinyl-benzene (1) forms unstable complexes with PtCl4, HgCl2, AuCl, AuCl3, and HAuCl4. The spontaneous decomposition of them gives 2, halogen-containing indeno-indenes (3a, b; 4a, b) and a dimeric indeno-indene (5). By a different route 5 can also be obtained from 2 in a 70 percent yield. Structure and properties of 3-5 are reported. Hydrogenation of 5 gives the hexahydrogenated derivative 6.
    Notes: 1.2-Bis-phenyläthinyl-benzol (1) bildet außer mit PdCl2 unbeständige Komplexe mit PtCl4, HgCl2, AuCl, AuCl3 und HAuCl4, deren freiwillige Zersetzung neben 5-Phenyl-indeno[2.1-α]inden (2) Halogen-haltige Indeno-indene (3a, b; 4a, b) ein dimeres Indeno-inden (5)liefert. Letzteres kann aus 2 auf anderem Wege in 70proz. Ausbeute erhalten werden. Struktur und Eigenschaften von 3-5 werden mitgeteilt. Hydrierung von 5 liefert das Hexahydro-Derivat 6.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 713 (1968), S. 40-48 
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1.2-Bis-phenyläthinyl-benzol (1) bildet mit PdC12 die Pd-Komplexe C44H28 · PdCl2 (2) und C45H32 · PdCl2 (3), mit PtCl4 den nicht isolierbaren Komplex 4, deren Zersetzung zu neuen Verbindungen führt. In 85-proz. Ausbeute wird aus 4 neben noch unbekannten Stoffen 5-Phenyl-indeno[2.1-α]inden (5) erhalten, dessen Struktur durch IR-, UV-, Massen- und NMR-Spektroskopie sowie durch Synthese gesichert wird. - Komplexstrukturen und Reaktionsmechanismus werden erörtert.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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