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  • 1
    Electronic Resource
    Electronic Resource
    Lymphocytotoxic autoantibodies in progressive systemic sclerosis (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 399-404 
    Details
    ISSN: 1432-069X
    Keywords: Progressive systemic sclerosis ; Microlymphocytotoxicity test ; Lymphocytotoxic autoantibodies ; Antinuclear antibodies ; T-helper lymphocytes ; Western-blot technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 53 patients with progressive systemic sclerosis (PSS) the lymphocytotoxic activity of their serum was measured in a microlymphocytotoxicity assay. In 21 of the 53 patients the test reacted distinctly positively in the heterologous system, and in 9 of these 21 also in the autologous system. After preparation of the immunoglobulins from these positive sera, whole cytotoxic activity was detected only in the IgM fraction but not in the IgG fraction. When using prepared T lymphocytes as target cells in the microlymphocytotoxicity test, the cytotoxic activity of the positive PSS sera showed itself to be directed against this lymphocyte population. Further analysis using the Western-blot technique showed that the IgM autoantibody in PSS sera reacted with the cell surface of CD4+ lymphocytes. The cross reactivity with extractable nuclear antigens was rather improbable. These results suggest that lymphocytotoxic autoantibodies may play a role in immunological disturbances in PSS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429977
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mikrochimerismus Neuer Denkansatz für die Pathogenese der systemischen Sklerodermie (2000)
    Springer
    Der Hautarzt 51 (2000), S. 59-62 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Systemische Sklerodermie ; Graft-versus-Host-Erkrankung ; Mikrochimerismus ; Key words Systemic sclerosis ; Graft-versus-host-disease ; Microchimerism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Persistent cellular microchimerism might play a role in the pathogenesis of systemic sclerosis (SSc). Microchimerism results from the traffic of fetal cells through the placenta during pregnancy into the maternal circulation and their survival due to HLA class II compatibility. In female SSc patients the presence of fetal CD3-positive T-cells in the maternal circulation and of fetal cells in the affected skin tissue has been identified through y chromosome specific DNA sequences. The persistent microchimerism might cause SSc in certain patients by initiating a fetal anti-maternal Graft-versus-host-like response.
    Notes: Zusammenfassung Ein persistierender zellulärer Mikrochimerismus könnte in der Pathogenese der systemischen Sklerodermie (SSc) eine Rolle spielen. Der Mikrochimerismus entsteht durch den Transport fetaler Zellen durch die Plazenta während der Schwangerschaft in die maternale Zirkulation und deren Überleben aufgrund einer weitgehenden HLA-Klasse-II-Kompatibilität. Bei weiblichen SSc-Patienten wurde die Anwesenheit von fetalen CD3-positiven T-Zellen in der maternalen Zirkulation und von fetalen Zellen im befallenen Hautgewebe in Form von Y-Chromosomen-spezifischen DNA-Sequenzen nachgewiesen. Der persistierende Mikrochimerismus könnte bei bestimmten Patienten über eine fetoantimaternale Graft-versus-Host-ähnliche Reaktion eine SSc auslösen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050012
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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