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  • synaptosomes  (2)
  • Antioxidant enzymes  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Changes induced by aging and drug treatment on cerebral enzymatic antioxidant system (1988)
    Springer
    Neurochemical research 13 (1988), S. 467-478 
    Details
    ISSN: 1573-6903
    Keywords: Antioxidant enzymes ; aging ; peroxidation ; drug treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The age-related modifications of the participants to the cerebral enzymatic antioxidant system (superoxide dismutase, glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase) were evaluated in four brain regions from male Wistar rats aged 5, 10, 15, 20, 25, 30, and 35 months. Both the specific enzyme activity and the profile of any enzyme tested markedly differ with age according to the region examined: parieto-temporal cortex, caudate-putamen, substantia nigra and thalamus. This inhomogeneous age-related profile of enzyme activities could explain both the controversial data of literature and the different regional vulnerability of the brain tissue to damage with aging. In rats aged 10, 20, or 30 months, the chronic i.p. treatment for two months with papaverine or ergot alkaloids (dihydroergocristine, dihydroergocornine, dehydroergocriptine) suggests that the antioxidant enzyme activities may be influenced according to the agent utilized, the brain region tested, and the age of the animal. In any case, small differences in the drug structure support marked differences in the type and extent of the intervention on the antioxidant enzymatic system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01268883
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Synaptosomal non-mitochondrial ATPase activities and drug treatment (1993)
    Springer
    Neurochemical research 18 (1993), S. 719-726 
    Details
    ISSN: 1573-6903
    Keywords: Almitrine ; ATPases ; clonidine ; δ-yohimbine ; synaptosomes ; theniloxazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Energy-using non-mitochondrial ATPases were assayed in rat cerebral cortex synaptosomes and synaptosomal subfractions, namely synaptosomal plasma membranes and synaptic vesicles. The following enzyme activities were evaluated: Na+, K+-ATPase; high- and low-affinity Ca2+-ATPase; basal Mg2+-ATPase; Ca2+, Mg2+-ATPase. The evaluations were performed after four week-treatment with saline [controls] or α-adrenergic agents (δ-yohimbine, clonidine), energymetabolism interfering compound (theniloxazine), and oxygen-partial pressure increasing agent (almitrine), in order to define the plasticity and the selective changes in individual ATPases. In rat cerebral cortex, the enzyme adaptation to four-week-treatment with δ-yohimbine or clonidine was characterized by increase in both high- and low-affinity Ca2+-ATPase activities. The action involves the enzyme form located in the synaptic plasma membranes. The enzyme adaptation to the subchronic treatments with theniloxazine or almitrine was characterized by increase in Na+, K+-ATPase or Mg2+-ATPase activities, respectively. The action involves the enzymatic forms located in the synaptic plasma membranes. Thus, the pharmacodynamic effects of the agents tested should also be related to the changes induced in the activity of some specific synaptosomal nonmitochondrial ATPases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00966787
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Parkinson-like disease by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity inMacaca Fascicularis: Synaptosomal metabolism and action of dihydroergocriptine (1994)
    Springer
    Neurochemical research 19 (1994), S. 229-236 
    Details
    ISSN: 1573-6903
    Keywords: Parkinson-like syndrome by MPTP ; enzymes ; synaptosomes ; energy metabolism ; dihydroergocriptine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The maximal rates (Vmax) of some enzyme activities related to synaptosomal energy metabolism were studied in different types of synaptosomes from cerebellar cortex ofMacaca Fascicularis (Cynomolgus monkey). Different synaptosomal populations, namely “large” and “small” synaptosomes, were isolated from the anterior lobule of the cerebellar cortex of monkeys treated p.o. with dihydroergocriptine at the dose of 12 mg/kg/day before and during the induction of a Parkinson's-like syndrome by MPTP administration (i.v., 0.3 mg/kg/day for 5 days). The enzymes were chosen according to their regulatory role and as markers of the following metabolic pathways: (a) glycolysis ((hexokinase, phosphofructokinase, lactate dehydrogenase), (b) Krebs' (TCA) cycle (citrate synthase, malate dehydrogenase), (c) amino acid, glutamate metabolism (glutamate dehydrogenase, glutamate-pyruvate- and glutamate-oxaloacetate-transaminases), (d) acetylcholine catabolism (acetylcholinesterase) and (e) ATPases, i.e. Na+−K+-ATPase, Mg2+-ATP synthetase, Mg2+-ATPase, Ca2+−Mg2+-ATPase and Ca2+-ATPase Low and High affinity for Ca2+. The MPTP administration modified the activities of citrate synthase, malate dehydrogenase, Na+−K+-ATPase, acetylcholinesterase and glutamate-oxaloacetate transaminase only on selected types of synaptosomes. Pharmacological treatment by dihydroergocriptine was able to recovery at the steady-state levels the activities of these enzymes, thus demonstrating a partial protective effect on these biochemical parameters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00971569
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    Paper (German National Licenses)
    Fulltext
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