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  • Apomorphine  (3)
  • Dominant-Subordinate Behaviour  (2)
  • 1
    Electronic Resource
    Electronic Resource
    A putative multipartite model of haloperidol interaction in apomorphine-disturbed behavior of the dog (1978)
    Springer
    Psychopharmacology 59 (1978), S. 255-258 
    Details
    ISSN: 1432-2072
    Keywords: Dog ; Self-stimulation ; Apomorphine ; Haloperidol ; Stimulus control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The interaction between various doses of apomorphine and haloperidol on intracranial self-stimulation in the dog was studied using a pradigm in which reinforcing brain-stimulation was controlled by a discriminative auditory stimulus. Reinforced leverpressing was decreased by low doses of apomorphine and completely suppressed by stereotypogenic doses. At various doses of apomorphine, low doses of haloperidol either increased response inhibition by enhancing stereotypy, or increased lever pressing by reducing stereotypy while concomitantly increasing the number of nonreinforced responses. Intermediate to relatively high doses of haloperidol antagonized stereotypy and the response inhibition produced by apomorphine. High doses of haloperidol antagonized stereotypy but also suppressed self-stimulation. Thus, haloperidol is not only able to restore performance capability, but also disturbed reinforcing and discriminative stimulus control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426630
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Behavioural activity of rats measured by a new method based on the piezo-electric principle (1987)
    Springer
    Psychopharmacology 93 (1987), S. 382-388 
    Details
    ISSN: 1432-2072
    Keywords: Motor activity ; Locomotion ; Behaviour ; Methods ; Haloperidol ; Apomorphine ; Amphetamine ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spontaneous and drug-induced (haloperidol, apomorphine, and amphetamine) motor activity of rats was measured simultaneously via two distinct and independent methods: the classical optical scanning technique and a new procedure based on the piezo-electric principle. The latter procedure measured animal-induced mechanical vibrations of a flexible cage floor which were transduced into electric signals via piezo-electricity. The piezo method appeared to be relatively more sensitive in recording the small, stereotyped motor movements induced by apomorpine (0.63–≧10 mg/kg) and high doses of amphetamine (2.5–≧20 mg/kg). The optical scanning technique, on the other hand, was more sensitive in recording horizontal displacements across the cage such as induced by low doses of amphetamine (0.31–2.5 mg/kg). Both methods showed comparable sensitivity in recording the depression of behaviour induced by haloperidol (0.04–≧1.25 mg/kg) or low doses of apomorphine (0.04–0.16 mg/kg). The piezo method may complement the optical scanning procedure, and thereby enhance the information on the extent that test compounds modify animal behaviour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00187261
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Intracranial self-stimulation in rats as a function of various stimulus parameters (1973)
    Springer
    Psychopharmacology 30 (1973), S. 163-172 
    Details
    ISSN: 1432-2072
    Keywords: Apomorphine ; Rats ; Self-Stimulation ; Medial Forebrain Bundle ; Monopolar Electrodes ; Various Stimulus Parameter Combinations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of different subcutaneous doses (0.08, 0.16, 0.31, 0.63 and 1.25 mg/kg) of apomorphine on self-stimulation in rats, with monopolar nichrome electrodes, implanted in the medial forebrain bundle at the level of the lateral hypothalamus were studied. Six different selected stimulus parameter combinations inducing different predictable response rates were used. Apomorphine was found to produce a dose-related response stimulation and a dose-related response depression. The highest stimulation was obtained at 0.63 mg/kg, the highest depression at 1.25 mg/kg. The response stimulation with apomorphine was 1. inversely related to the control response rate, i.e. the higher the control response rate, the lower the response stimulation after apomorphine and vice versa, 2. directly related to the control response rate of the individual rats, i.e. the highest response stimulation was obtained with the most sensitive rat and vice versa. The response inhibition with apomorphine was not related to the control response rates but was more pronounced during the first 1/2 h of the session. It is postulated that 1. increased self-stimulation with apomorphine could be the result of an increased motor response output; 2. decreased self-stimulation with apomorphine could be due to non-adaptive behaviour as a result of non-physiological overexcitation with interruption of integrated behaviour; 3. a complex behavioural pattern like intracranial self-stimulation depends on different interacting systems, mediated by different transmitters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421431
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The effects of pimozide on dominant-subordinate behaviour in wistar rats competing for food (1973)
    Springer
    Psychopharmacology 31 (1973), S. 49-62 
    Details
    ISSN: 1432-2072
    Keywords: Rats ; Dominant-Subordinate Behaviour ; Food Competition ; Aggressiveness ; Pimozide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A new procedure for studying dominant-subordinate (D-S) relationship in pairs of rats, competing for food, is described. The experimental design has the advantage of being stable for a long time without “spontaneous” D-S reversals. The method was used for testing the effects of pimozide, a highly potent and long-acting neuroleptic, on D-S behaviour. Treating the dominant rat of a pair (subcutaneously, 4 h before the test session), a significant weakening of the initially strong D-S relationship was demonstrated with a dose of 0.16 mg/kg, while 0.63 mg/kg of pimozide resulted in a nearly complete D-S reversal. Significant changes of D-S relationship were not observed when the subordinate rat was treated with 0.08, 0.16 or 0.31 mg/kg of pimozide. The results point at a normalizing effect of pimozide on social interaction through inhibition of aggressive behaviour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429298
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The effects of azaperone, a sedative neuroleptic of the butyrophenone series, on dominant-subordinate behaviour in wistar rats competing for food (1975)
    Springer
    Psychopharmacology 41 (1975), S. 285-289 
    Details
    ISSN: 1432-2072
    Keywords: Rats ; Dominant-Subordinate Behaviour ; Food Competition ; Aggressiveness ; Azaperone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of azaperone, a sedative neuroleptic of the butyrophenone series with outstanding anti-aggressive and anti-shock activity on dominant-subordinate relationship in pairs of rats, competing for food, are described. Treating the dominant rat of a pair with azaperone, a dose related weakening (at 0.16 and 0.31 mg/kg) and reversal (at 0.63 mg/kg and above) of the initial strong dominant-subordinate relationship is demonstrated. At 5 mg/kg the dominant-subordinate reversal is complete until the end of the test session. Dominant-subordinate relationships are modified by azaperone at doses far below those inducing gross behavioural changes. The present results point at a normalizing effect of azaperone on social interaction through inhibition of aggressive responsiveness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428938
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    Paper (German National Licenses)
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