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  • 1
    Electronic Resource
    Electronic Resource
    Cell death caused by the acute effects of aminoglycoside and zinc in the ampullary cristae of guinea pigs (1997)
    Springer
    European archives of oto-rhino-laryngology and head & neck 254 (1997), S. 153-157 
    Details
    ISSN: 1434-4726
    Keywords: Apoptosis ; Labyrinthine vestibule ; Aminoglycoside toxicity ; Zinc toxicity ; Nick-end labeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We reported that apoptosis occurred in the guinea pig vestibular hair cells after chronic aminoglycoside treatments. In the present study, we used in situ nick-end labeling to determine whether apoptosis was also induced by the acute effects of aminoglycosides in guinea pig ampullar cristae. In addition, we evaluated the effect of zinc supplements upon these ototoxic treatments. After a local application of streptomycin directly to the round window, we found labeled bodies in the vestibular hair cells. The zinc supplement increased the number of labeled bodies resulting in severe hair cell loss. These findings indicate that the acute effects of aminoglycosides also induce apoptosis of the vestibular hair cells, and that zinc enhances aminoglycoside ototoxicity. Consequently, we propose that an interaction with ion channels may play a key mechanism in the processes of apoptosis affecting the vestibular hair cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471281
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Regulation of inner ear fluid in the guinea pig cochlea after the application of saturated NaCl solution to the round window membrane (1999)
    Springer
    European archives of oto-rhino-laryngology and head & neck 256 (1999), S. S2 
    Details
    ISSN: 1434-4726
    Keywords: Key words Clochlear physiology ; Potassium ion and ; sodium ion transport ; Endolymph ; Perilymph
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The regulation of K+ and Na+ in the inner ear fluid of the guinea pig was studied after the application of saturated NaCl solution to the round window membrane. K+ and Na+ activities in the scala tympani increased rapidly and then decreased. K+ activity in the scala media increased immediately, but Na+ activity continued to increase during the period of observation. K+ activity in the scala vestibuli continued to increase in the observation period. Na+ activity in the scala vestibuli increased and then decreased. The endocochlear potential decreased immediately to approximately 20% of its initial level. Total activities of K+ and Na+ increased immediately and then decreased in both the scala tympani and scala media. The total activity of K+ and Na+ increased slowly and showed no regulatory decrease in the scala vestibuli. Thus, changing patterns in the total activity of K+ and Na+ were similar for the scala tympani and scala media, but not for the scala media and the scala vestibuli. Different patterns of K+ and Na+ activities among the three scalae indicate that their mechanisms for regulating inner ear fluid differ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00014147
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Apoptosis in the normal olfactory epithelium of the adult guinea pig (1996)
    Springer
    European archives of oto-rhino-laryngology and head & neck 253 (1996), S. 371-373 
    Details
    ISSN: 1434-4726
    Keywords: Olfactory epithelium ; Apoptosis ; Nucleic acid labeling ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Among nerve cells of vertebrates, the olfactory epithelia are uncommon in their capacity for cell turnover. Apoptosis is well known to play a key role in maintaining homeostasis in continuously renewing tissues. We examined whether true apoptosis occurred in the normal olfactory epithelia of healthy adult guinea pigs using nucleic acid labeling. Subsequently, apoptosis was recognized in olfactory nerve cells, indicating that apoptosis might play a role in turnover of the olfactory epithelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178295
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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