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Ultrastructural observations on cell necrosis during formation of the neural tube in mouse embryos (1973)

Schlüter, G.

Springer

Anatomy and embryology 141 (1973), S. 251-264

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ISSN: 1432-0568

Keywords: Closure of neural tube ; Cell necrosis ; Normal mouse embryos ; Electron microscopy

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Spontaneous cell death in the developing brain of 8.5–9 day old mouse embryos has been investigated with the electron microscope. Before closure of the neural tube, areas of cell death are found at the neuro-somatic junction. After closure of the neural tube degenerating cells are found in the dorsal midline of the prospective diencephalon. Ultrastructurally, cell degeneration is marked by chromatin condensation, increase in electron density of the structures in the cytoplasm and, in later stages, by a marked pycnosis of the dying cell. After fragmentation, the necrotic material as well as entire pycnotic cells are phagocytized and digested by cells of the neuroepithelium. An invasion of macrophages has not been observed. The significance of cell necrosis is discussed in relation to the normal formation of the neural tube and to the occurrence of certain induced malformations (exencephalies).

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00519046

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Fluoreszenzmikroskopischer Nachweis von Arginin im Neurosekret des Schweines mit Phenanthrenchinon (1971)

Bock, R. ; Schlüter, G.

Springer

Cell & tissue research 122 (1971), S. 456-459

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ISSN: 1432-0878

Keywords: Neurosecretory material ; Carrier protein ; Arginine ; Phenanthrenequinone ; Pig

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Description / Table of Contents: Zusammenfassung Das Neurosekret im Hypophysenhinterlappen des Schweines enthält Arginin. Dieser in einer voraufgegangenen Untersuchung mit Hilfe der Ninhydrin-Reaktion erhobene Befund wird durch die vorliegende Mitteilung bestätigt, bei der zum Argininnachweis die Phenanthrenchinon-Reaktion benutzt wurde. Aus den Befunden ist zu folgern, daß das Neurosekret als Äquivalent der Trägerproteine anzusehen ist, da die Hormone selbst beim Schwein argininfrei sind.

Notes: Summary By using the phenanthrenequinone-reaction it is shown that the neurosecretory material in the posterior lobe of the hypophysis in pigs contains arginine. This finding confirms results previously obtained by using the ninhydrine reaction. Since in pigs the hormones vasopressin and oxytocin are free of arginine, the findings indicate that the neurosecretory material represents the carrier proteins.