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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 62 (1984), S. 1102-1107 
    ISSN: 1432-1440
    Keywords: Anorexia ; Aromatic amino acids ; Branched-chain amino acids ; Dopaminergic neurons ; Neoplastic diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Studies in anorectic tumor-bearing rats indicate that anorexia is correlated to imbalances of neutral amino acids in blood and CNS. Consequently plasma amino acids of patients with neoplastic and non-neoplastic internal diseases were studied during phases of anorexia; special regard was given to the precursors of dopamine and serotonin. Anorectic patients were compared to non-anorectic patients with neoplasia. During anorexia, plasma levels of valine and leucine and hence the ratio of the molar concentrations of Val+Leu+Ile/Phe+Tyr were significantly decreased in each anorectic patient as compared to non-anorectic patients whose ratios were always within the normal ranges. As aromatic and branched-chain amino acids compete for penetration of the blood brain barrier, the decrease of the amino acid ratio may induce a raised flux of phenylalanine and tyrosine into the CNS which results in an increased activation of dopaminergic neurons — known to cause anorexia.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 172 (1978), S. 143-154 
    ISSN: 1433-8580
    Keywords: Haematocrit ; Blood electrolytes ; Conductometry ; Continuous measurements ; Hemodialysis ; Hämatokrit ; Blutelektrolyte ; Konduktometrie ; Fortlaufende Messungen ; Hämodialyse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der arterielle Hämatokrit und die Gesamtelektrolytkonzentration werden bei 3 Hämodialysepatienten fortlaufend mittels Konduktometrie gemessen. Anstieg des Hämatokritwertes während der Mahlzeiten, besonders wenn sie kohlenhydratreich sind, deuten auf Flüssigkeitsverluste aus dem Blut hin. Gleichzeitig weisen biphasische Veränderungen der Elektrolytkonzentration auf osmotische und diffusive Wasser- und Elektrolytverschiebungen hin. Blutvolumen- und Elektrolytkonzentrationsänderungen während und nach intravenösen Infusionen von Kolloid- und Krystalloidlösungen können ebenfalls verfolgt werden. Die sich aus den Messungen ergebenden quantitativen Aspekte werden diskutiert.
    Notes: Summary Arterial haematocrit and blood electrolyte concentrations are measured continuously by conductometry in three hemodialysis patients. Haematocrit elevation during meals, particularly when rich in carbohydrates, indicate fluid losses into the gut. Simultaneous biphasic responses in electrolyte concentration indicate osmotic and diffusional shifts of water and electrolytes. Similarly, blood volume and electrolyte concentration changes can be followed during and after intravenous infusions of colloid and crystalloid solutions. The quantitative aspects of such measurements are discussed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Planta 168 (1986), S. 101-105 
    ISSN: 1432-2048
    Keywords: Catharanthus (cell cycle) ; Cell cycle ; Glycoprotein ; Nicotiana (cell cycle) ; Tunicamycin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The effect of tunicamycin, an inhibitor of N-glycosylation of proteins, on growth and on synthesis of DNA and protein was studied in suspension cultures from Nicotiana tabacum and Catharanthus rosea. In the presence of 0.1–1 μg · ml-1 tunicamycin, cell division and DNA synthesis stopped in cells which had been proliferating logarithmically, but protein formation continued. Cytophotometric determination of the nuclear DNA content in Catharanthus cells showed that a cell-cycle arrest had occurred in G1 phase. Metabolic labelling of cells with the glycoprotein precursors glucosamine or mannose was inhibited, too. The results indicate that one or more glycoproteins are needed for the cell to pass through the G1 phase, as was recently postulated for animal and yeast cells.
    Type of Medium: Electronic Resource
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