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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 20-30 
    ISSN: 1432-1912
    Keywords: Embryotoxic Actions ; Trypan Blue ; Time Factor ; Trypanblau ; Embryotoxicität ; Behandlungszeitpunkt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The embryotoxic effect of a single dose of trypan blue given to pregnant mice (NMRI/Han-strain) on different days of pregnancy was studied. Seven groups each comprising 10–27 animals were subcutaneously injected with 1% trypan blue solution in a dose of 100 mg/kg body weight. The injection was performed on the 6th, 7th, 8th, 9th, 10th, 11th or 14th day of gestation. 40 animals, forming a control group received a single injection of saline over the same period. The findings were as follows: 1. A statistically higher rate of malformations in comparison to the control group is found to occur when the injection of trypan blue is made between the 6th and 10th day of pregnancy. Within this period the strongest teratogenic activity is observed when the trypan blue is administered on the 8th day of gestation. 2. The rate of resorptions in trypan blue treated animals over the period of pregnancy examined shows a significant increase over that of the control group. Here again the maximum is reached when the trypan blue has been injected on the 8th day. The effect of earlier and later injections is noticeably less. 3. The rate of retardation is increased by injections of trypan blue from the 8th day of gestation onward and by the 14th day the maximum has still not been attained. The morphology of the observed resorptions as well as that of the retarded and malformed fetuses is described.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Anatomy and embryology 128 (1969), S. 28-39 
    ISSN: 1432-0568
    Keywords: Arterial supply ; Corpus callosum ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 27 Katzen beiderlei Geschlechts wurde die Blutversorgung des Corpus callosum untersucht. Dabei wurden folgende Befunde erhoben: Der Balken der Katze wird im Bereich des Rostrum und Genu sowie im vorderen und mittleren Truncuabschnitt aus der Arteria cerebri anterior versorgt und zwar über Äste, die den Arteriae pericallosae und den Arteriae genu corporis callosi entstammen. Diese Äste wurden als Arteriae callosi superiores und inferiores bezeichnet. Lediglich im hinteren Truncusabschnitt und im Splenium erfolgt die Versorgung neben Ästen der A. pericall. auch über solche der Arteriae cerebri mediae und posteriores. Die Blutgefäße treten dolchartig in den Balken ein, teilen sich dann baumartig weiter auf und gehen in ein Capillarnetz über, das in Richtung des Nervenfaserverlaufes ausgezogen ist. Auf in der Literatur bereits bekannte, aber oft vernachlässigte Besonderheiten der Arteria carotis interna und des Circulus arteriosus wird hingewiesen.
    Notes: Summary In investigations on 27 cats of both sexes, the arterial supply of the corpus callosum was studied. The findings are as follows: In the region comprising rostrum and genu as well as in the fore and middle trunk sections, blood supplied by branches of the arteriae pericallosae and the arteriae genu corporis callosi which originate from the arteria cerebri anterior. These branches were designated arteriae callosi superiores and inferiores. However, in the posterior section of the trunk and in the splenium the blood is supplied by branches of the aa. pericall. and, in addition, by branches of the arteriae cerebri media and posteriores. The blood vessels penetrate the corpus callosum in bayonet fashion, then arborise and finally become a capillary network which is elongated in the direction of the course of the nerve fibres. Attention is drawn to peculiarities of the arteria carotis interna and the circle of Willis which, although known in the literature, are rarely referred to.
    Type of Medium: Electronic Resource
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