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  • Artery, renal, stenosis  (1)
  • capsules  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of beta-methyl digoxin compared with digoxin tablets and capsules (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 231-236 
    Details
    ISSN: 1432-1041
    Keywords: Digoxin ; beta-methyl-digoxin ; capsules ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The intestinal absorption and urinary elimination rate of total cardioactive material was compared following digoxin and beta-methyldigoxin (BMD) administration to twelve healthy volunteers. Significantly more injected digoxin was recovered in urine. Urinary clearance was more rapid for digoxin, mean half-lives of elimination being 35 hours for digoxin and 40 hours for BMD. Calculated percentage intestinal absorption was lowest for digoxin tablets with a dissolution rate of 77% in one hour, intermediate for BMD tablets, and maximal for an experimental soft gelatin formulation of digoxin in solution. Respective mean values were 75%, 87% and 97%. Similar steady state plasma concentrations followed twice daily ingestion of the 0.25 mg digoxin tablets and 0.20 mg BMD tablets. Mean peak plasma concentration and percentage urinary recovery of ingested dose were higher during continued BMD administration. Between-subject variation in absorption was higher for the digoxin tablets. The comparative intestinal absorption of BMD and digoxin depends upon the formulation. Digoxin is virtually completely absorbed from a solution encapsulated in soft gelatin. Relatively more BMD is eliminated by nonrenal routes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558334
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Percutaneous transluminal angioplasty in transplant renal arterial stenoses: a long-term follow-up (1992)
    Springer
    Transplant international 5 (1992), S. 129-132 
    Details
    ISSN: 1432-2277
    Keywords: Renal artery stenosis ; Artery, renal, stenosis ; Angioplasty, renal artery ; Hypertension, renal artery stenosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Transplant renal artery stenosis is a potentially treatable cause of post-transplant hypertension. Transluminal angioplasty under radiological control facilitates treatment, and in this study the results of 15 consecutive patients treated in one department have been analysed to assess the safety and success of the technique, blood pressure control and transplant function. Technical success was achieved in 14 patients (93%), with zero mortality and only 1 major complication requiring surgical intervention. Blood pressure control was significantly improved by angioplasty, mean blood pressure (diastolic+1/3 pulse pressure) being lower 4–6 weeks later (P(0.05) and a mean of 34 months later (P(0.01), and transplant renal function was unaffected. In the treatment of transplant renal artery stenosis percutaneous transluminal angioplasty is effective, safe and often of lasting benefit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336596
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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