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  • Arthritis  (1)
  • Complement deficiency  (1)
  • Disseminated intravascular coagulation  (1)
  • Drosophila  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of IL-10 on collagen-induced arthritis in mice (1996)
    Springer
    Inflammation research 45 (1996), S. 283-288 
    Details
    ISSN: 1420-908X
    Keywords: IL-10 ; Collagen ; Arthritis ; Macrophage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study we investigated the effect of a potent anti-inflammatory cytokine, interleukin (IL)-10, on the development of collagen-induced arthritis (CIA) in mice. Each DBA1/J mouse was immunized with 200 μg of native collagen and followed by booster injections at 3 weeks. rmIL-10 was injected i.p. daily at a dose of 100 ng/mouse. Mice were divided into four groups according to the administration period of rmIL-10. As a result, a 48-day course of IL-10 treatment significantly suppressed the severity of arthritis. Among the 4 groups, the most pronounced suppression was observed in the group in which IL-10 was given from day 0 to 21. On the other hand, there were no significant differences in the serum IgG anti-type II collagen (CII) titers between the four groups. Moreover, the production of cytokines (IL-6 and tumor necrosis factor-α (TNF-α)) and other mediators (prostaglandin E2 (PGE2) and nitric oxide (NO)) by peritoneal macrophages seemed to show no clear correlation with the severity of arthritis in mice. These results raise the possibility that IL-10 might be a useful agent for suppressing the progression and the development of CIA in mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02280992
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Use of a synthetic protease inhibitor for the treatment ofl-asparaginase-induced acute pancreatitis complicated by disseminated intravascular coagulation (1992)
    Springer
    Annals of hematology 64 (1992), S. 249-252 
    Details
    ISSN: 1432-0584
    Keywords: l-Asparaginase ; Drug-induced pancreatitis ; Protease inhibitors ; Consumption coagulopathy ; Disseminated intravascular coagulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In two patients receivingl-asparaginase therapy, severe acute pancreatitis complicated by disseminated intravascular coagulation (DIC) developed. In both cases it was successfully treated with continuous infusion of a synthetic protease inhibitor, nafamostat mesilate. In this report, we briefly discuss the clinical efficacy of the synthetic protease inhibitor in treating such cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01738305
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Behçet's disease associated with complement component 9 (C9) deficiency (2000)
    Springer
    Modern rheumatology 10 (2000), S. 276-278 
    Details
    ISSN: 1439-7609
    Keywords: Key words Behçet's disease ; Complement component 9 (C9) ; Complement deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Behçet's disease is a multisystem inflammatory disorder with unknown etiology. It has been shown that the titer of plasma complement component 9 (C9) is a good indicator of the disease activity. Therefore, the involvement of C9 in the pathogenesis of Behçet's disease has been suggested. We report a case of Behçet's disease associated with complete C9 deficiency (C9D) carrying the homozygous nonsense mutation at Arg-95 of C9 (R95X). The patient presented the typical characteristics of Behçet's disease, such as uveitis, recurrent oral aphthae and genital ulcers, and arthritis, suggesting that C9 does not play an essential role in the pathogenesis of Behçet's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101650070017
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Meiotic mutations from natural populations ofDrosophila melanogaster (1993)
    Springer
    Genetica 88 (1993), S. 165-173 
    Details
    ISSN: 1573-6857
    Keywords: Drosophila ; meiosis ; recombination ; spermatogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Two meiotic genes from natural populations are described. A female meiotic mutation,mei(1)g13, mapped to 17.4 on the X chromosome, causes nondisjunction of all homologs except for the fourth chromosomes. In addition, it reduces recombination by 10% in the homozygotes and causes 18% increased recombination in the heterozygotes. A male meiotic mutation,mei-1223 m144 , is located on the third chromosome. Although this mutation causes nondisjunction of all chromosomes, each chromosome pair exhibits a different nondisjunction frequency. Large variations in the sizes of the premature sperm heads observed in the homozygotes may reflect irregular meiotic pairing and the subsequent abnormal segregation, resulting in aneuploid chromosome complements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02424473
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    Paper (German National Licenses)
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