ISSN:
1420-908X
Keywords:
Isoquinoline
;
Arthritis
;
Anti-inflammatory
;
Alkaloid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Two isoquinoline plant alkaloids, tetrandrine (1) and berbamine (2), have been evaluated for anti-inflammatory activity in an acute paw oedema assay and in adjuvant-induced arthritis in rats.1 but not2 suppressed the chronic inflammation in the arthritis model but neither compound was active in the acute inflammation assay. In the adjuvant-induced polyarthritis,1 was not effective when given at the time of inoculation (Day 0), nor just before (Day 7–10) signs of arthritis were evident. However, when given on a therapeutic dose schedule (Days 10–13) or continually (Day −1 to +14) on a prophylactic schedule, signs of arthritis including weight loss due to cachexia were significantly reduced. Given orally,1 was considerably more potent than aspirin but not gastro-irritant and may be a promising lead for the development of a safe and effective treatment of chronic inflammatory diseases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01983477
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