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  • 1
    Electronic Resource
    Electronic Resource
    Anti-inflammatory activity of the isoquinoline alkaloid, tetrandrine, against established adjuvant arthritis in rats (1994)
    Springer
    Inflammation research 42 (1994), S. 123-127 
    Details
    ISSN: 1420-908X
    Keywords: Isoquinoline ; Arthritis ; Anti-inflammatory ; Alkaloid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two isoquinoline plant alkaloids, tetrandrine (1) and berbamine (2), have been evaluated for anti-inflammatory activity in an acute paw oedema assay and in adjuvant-induced arthritis in rats.1 but not2 suppressed the chronic inflammation in the arthritis model but neither compound was active in the acute inflammation assay. In the adjuvant-induced polyarthritis,1 was not effective when given at the time of inoculation (Day 0), nor just before (Day 7–10) signs of arthritis were evident. However, when given on a therapeutic dose schedule (Days 10–13) or continually (Day −1 to +14) on a prophylactic schedule, signs of arthritis including weight loss due to cachexia were significantly reduced. Given orally,1 was considerably more potent than aspirin but not gastro-irritant and may be a promising lead for the development of a safe and effective treatment of chronic inflammatory diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983477
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  • 2
    Electronic Resource
    Electronic Resource
    Immunological competence of children with pyogenic meningitis (1981)
    Springer
    European journal of pediatrics 136 (1981), S. 231-235 
    Details
    ISSN: 1432-1076
    Keywords: Pyogenic meningigits ; Immunodeficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A broad range of immunological tests was performed on 9 consecutive children with pyogenic meningitis. Two were found to have combined IgG and IgA deficiency. One had a combination of IgG deficiency and impaired neutrophil chemotaxis. Primary immunodeficiency disorders as a predisposing cause of pyogenic meningitis may be more common than previously suspected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442989
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  • 3
    Electronic Resource
    Electronic Resource
    Allergic reactions to the Australian paralysis tick, Ixodes holocyclus: diagnostic evaluation by skin test and radioimmunoassay (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 19 (1989), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Allergic reactions to Ixodes holocyclus are well recognized but poorly defined. Tick-bite reactions in 42 individuals in this study fell into six classes. Skin-prick tests and radioimmunoassay (RIA) indicated that all systemic hypersensitivity (class 3) and atypical reactions (class 4) were IgE-mediated. Some 73% of the large local reactions (class 2) and only 12.5% of the small local reactions (class 1) were associated with IgE specific for tick allergens. Subjects who reported heavy exposure to tick-bite were more likely to have positive RIA values (P〈0.05). There was an association between the individual's atopic status and tick allergy (P〉0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1989.tb02384.x
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  • 4
    Electronic Resource
    Electronic Resource
    Reduced levels of IgG subclasses and IgA in young children with asthma (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Pediatric allergy and immunology 2 (1991), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Serum immunoglobulins including IgG subclasses were measured in 73 unselected children with asthma. The results showed that 22 (30%) had partial IgA and/or IgG4 subclass deficiency. Clinical assessment showed that 21 children were infection-prone, and 52 were not. Further analysis showed that infection-prone children were significantly different from non-infection-prone children with regard to familial history of allergy (29% vs 60%, p = 0.015), elevated IgE (62% vs 33%, p = 0.021), IgA deficiency (38% vs 15%, p = 0.38) and IgG subclass deficiency (24% vs 4%, p = 0.018). These results suggest that there may be subgroups of children with asthma who are also immunodeficient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3038.1991.tb00176.x
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  • 5
    Electronic Resource
    Electronic Resource
    IgG subclass deficiency in children with congenital heart disease (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Pediatric allergy and immunology 1 (1990), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study of 66 children with congenital heart disease found 26 (39%) with IgG subclass deficiency, the majority being of the IgG4 isotype. Conventional immunoiogical assessment (IgG, IgA, IgM, T cell) revealed 21 (32%) with immunodeficiency, while inclusion of IgG subclass assessment revealed a total of 35 (53%) of the 66 children had immuno-deficiency. Children with conotruncal lesions appeared to be predisposed to immunodeficiency affecting T cells and IgG subclasses (especially IgG4) while those with shunt and stenotic lesions had a broad spectrum of immunoglobulin deficiencies. There was significant correlation between immunodeficiency and proneness to infection in these children (p 〈 0.01). These results suggest that immunodeficiency is a frequent occurrence in children with congenital heart disease, and that IgG subclass measurements should be added to the diagnostic work-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3038.1990.tb00007.x
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  • 6
    Electronic Resource
    Electronic Resource
    Comparative effects of tetrandrine and berbamine on subcutaneous air pouch inflammation induced by interleukin-1, tumour necrosis factor and platelet-activating factor (1992)
    Springer
    Inflammation research 36 (1992), S. 112-118 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of the bisbenzylisoquinoline alkaloids tetrandrine and berbamine on the action of IL-1, TNF and PAF were investigated in the rat subcutaneous air pouch model of inflammation. Both compounds were equipotent in the suppression of leukocyte infiltration into air pouches induced by IL-1 and TNF, with ED50 values in the range 20–30 mg/kg/3 days. Both were also equiptent in suppression of PMN infiltration induced by PAF with ED50 values in the same range as that for IL-1 and TNF. However, tetrandrine was more potent than berbamine as a suppressant of PAF-induced MNC infiltration, but much less potent than berbamine in carageenen-induced PMN infiltration. These results suggest that these bisbenzylisoquinolines may have value in the therapy of chronic inflammatory diseases where IL-1, TNF and PAF have a role in pathogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01991238
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  • 7
    Electronic Resource
    Electronic Resource
    Induction of suppressor cells in mice followingVaccinia virus infection (1980)
    Springer
    Medical microbiology and immunology 168 (1980), S. 227-233 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Infection of mice withVaccinia virus produced suppression of responsiveness of spleen cells to mitogens in vitro and suppression of delayed-type hypersensitivity in vivo. The latter suppression was transferred to normal mice by spleen cells of virus-infected mice. The data presented show thatVaccinia virus-induced immunosuppression involves the inductionof suppressor cells which belong to both the adherent and non-adherent cell fractions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02122857
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  • 8
    Electronic Resource
    Electronic Resource
    Spectrum of Di George syndrome in patients with truncus arteriosus: Expanded Di George syndrome (1988)
    Springer
    Pediatric cardiology 9 (1988), S. 95-101 
    Details
    ISSN: 1432-1971
    Keywords: Truncus arteriosus ; Di George syndrome ; Immunodeficiency ; Prenatal risk factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A study of 26 patients with truncus arteriosus showed a high prevalence of facial dysmorphism, aortic arch abnormalities, extracardiac malformations, and significant prenatal risk factors. There was little evidence of parathyroid or thymic abnormalities. However, there was laboratory evidence of immune deficiency, especially T-helper lymphocytes, and clinical evidence of predilection to infection. These findings suggest that patients with truncus arteriosus belong to the spectrum of the Di George syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02083707
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  • 9
    Electronic Resource
    Electronic Resource
    The association between immunodeficiency and congenital heart disease (1988)
    Springer
    Pediatric cardiology 9 (1988), S. 103-108 
    Details
    ISSN: 1432-1971
    Keywords: Congenital heart disease ; Immunodeficiency ; “Compromised host” ; Immunological reconstitution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The predilection of children with congenital heart disease (CHD) to infection may be explained in part by an underlying immunodeficiency disorder. Some 13 syndromes in which immunodeficiency and CHD may coexist have been reported in the medical literature. In addition, immunoglobulin and T-cell deficiencies have been found in nonsyndromal patients with CHD. The diagnosis of immunodeficiency should be entertained in such children, as early recognition of an immunodeficiency disorder can result in improved antimicrobial and immunological management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02083708
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  • 10
    Electronic Resource
    Electronic Resource
    Nicotine-induced release of elastase and eicosanoids by human neutrophils (1994)
    Springer
    Inflammation 18 (1994), S. 119-127 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the direct effects of nicotine on a variety of neutrophil functions at concentrations achievable in lung and oral tissues from cigarette smoking. The results show dose-dependent suppression of chemotaxis and phagocytosis, and enhancement of degranulation and eicosanoid generation, but not superoxide production. Cell viability was not affected by the concentrations of nicotine used in these experiments, as shown by trypan blue dye exclusion and MTT assays. These results implicate nicotine as the ingredient in cigarette smoke responsible for inflammatory damage to lungs and oral tissues observed in cigarette smokers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01534553
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