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  • Axonal transport  (2)
  • Arthroplastie de hanche primaire  (1)
  • Clinical experience  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of orthopaedic surgery & traumatology 6 (1996), S. 105-108 
    ISSN: 1432-1068
    Keywords: Hip arthroplasty ; Infection of drain ; Arthroplastie de hanche primaire ; Infection de drain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs ont étudié la contamination bactérienne du liquide de drainage et des drains dans une série consécutive de 105 patients opérés d'une prothèse totale de hanche. Tous les patients ont été opérés dans une enceinte stérile de type Charnley Howorth Mark II, avec antibioprophylaxie systématique. Les prélèvements bactériologiques ont été réalisés au niveau de l'extrémité du drain, de sa lumière et au niveau de l'incision cutanée. Les cultures se sont révélées positives chez 27 patients, dont 21 fois au niveau de l'extrémité ou de la lumière du drain. Un staphylocoque coagulase négative a été retrouvé chez 15 patients, dont 12 fois au niveau de l'extrémité ou de la lumière du drain. Neuf patients avaient une culture positive au niveau de l'extrémité du drain et 16 au niveau de sa lumière. Quatre patients ont développé un hématome et un écoulement séreux. Aucun n'a présenté d'infection profonde pendant les 12 premiers mois après l'intervention. Cette étude confirme que les staphylocoques coagulase négative sont les germes les plus fréquemment rencontrés sur des prélèvements après prothèse totale de hanche. L'antibioprophylaxie doit en tenir compte.
    Notes: Abstract Bacterial growth in relation to suction drains and suction drain tubes following total hip replacements was studied in 105 consecutive patients. All the patients were operated on in a Charnley Howorth Mark II sterile enclosure without walls, but with a body exhaust system and routine antimicrobial prophylaxis. Specimens for culture were taken from the suction drain tip, from inside the suction tube and the incision site. Positive cultures were found in a7 patients; in 20 of them from either the drain tip or the drain track. In 15 patients, the culture revealed coa-gulase-negative staphylococci; in 12 of them from the drain tip or the drain track. Eight patients had a positive culture from the tip of the drain and 16 from the drain track. Four patients had signs of wound hematoma and serous discharge. No patient developed signs of deep infection during the first 12 months after surgery. This study confirms that coagulase-negative staphylococci are the most common single species obtained from cultures after total hip replacement. Routine antimicrobial prophylaxis against coagulase-negative staphylococci might be considered.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 6 (1996), S. S3 
    ISSN: 1432-1084
    Keywords: Contrast media ; Preclinical safety assessment ; Clinical experience
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of preclinical tests is to identify the potential benefits and risks of new diagnostic or therapeutic products. Regarding iodinated contrast media (CM), LD50 tests were used extensively in the past. However, from both scientific and ethical perspectives it is today highly relevant to question the use of LD50 tests. Due to species differences and the very high volume of CM needed to kill half of the animals, such tests are not sensitive enough to differentiate between modern nonionic CM. Further, they are not very predictive in terms of human tolerability. In other tests with more relevant end-points than death, overall tolerance to the new dimeric compound iodixanol (Visipaque), representing the latest step in the development of CM, has been shown to be higher than to tire nonionic monomers. Clinical experience has shown that the physiological parameters often stay closer to baseline alter Visipaque than after administration of conventional CM.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 16 (1973), S. 501-506 
    ISSN: 1432-1106
    Keywords: RNA ; Axonal transport ; Optic pathway
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Adult albino rabbits were injected into one eye with (3H) uridine. At various time intervals following the injections the amount of RNA-bound and acid soluble radioactivity was measured in the retrobulbar optic pathway. Evidence was obtained for a relatively slow transport of a small amount of macromolecular RNA along the axons of the retinal ganglion cells down to the nerve terminals.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 115 (1971), S. 265-283 
    ISSN: 1432-0878
    Keywords: Axonal transport ; Retina ; Colchicine ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Intraocular injection of colchicine in doses which do not affect the protein synthesis in the retina has profound effects on the axonal transport of protein in the retinal ganglion cells of the rabbit. Rapid axonal transport in these cells is completely inhibited after treatment with relatively low amounts of colchicine. In contrast to this, a certain fraction of the slow axonal transport is resistant to colchicine treatment. Colchicine in doses which completely inhibits fast axonal transport caused discrete morphological changes in the perikaryon and in the axon of the retinal ganglion cell. No disappearance of microtubules and no general proliferation of neurofilaments was observed in the perikaryon of the retinal ganglion cells. There was a slight or moderate increase in the number of filaments in the intra-retinal part of the axons of the retinal ganglion cells.
    Type of Medium: Electronic Resource
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