ISSN:
1432-1041
Keywords:
tolmesoxide
;
vasodilator
;
heart failure
;
pharmacokinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The haemodynamic effects and pharmacokinetics of single intravenous doses of tolmesoxide, a new vasodilator agent, were studied in 6 patients with severe cardiac failure secondary to ischaemic cardiomyopathy and refractory to concentional therapy. The mean (±SEM) baseline cardiac index (CI) and pulmonary artery diastolic pressure (PADP) were 1.7±0.11/ min/m2 and 30.5±4.1 mm Hg respectively. The mean % rise in CI was 78.8±23.3 and the mean % fall in PADP was 35.2±5.2. The mean half life of tolmesoxide in these patients was markedly prolonged at 15.6±6.6h. Side effects were minimal — vomiting was seen in 1 patient. This agent warrants further study in the long term management of refractory cardiac failure.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00627915
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