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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 21 (1981), S. 169-172 
    ISSN: 1432-1041
    Keywords: tolmesoxide ; vasodilator ; heart failure ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The haemodynamic effects and pharmacokinetics of single intravenous doses of tolmesoxide, a new vasodilator agent, were studied in 6 patients with severe cardiac failure secondary to ischaemic cardiomyopathy and refractory to concentional therapy. The mean (±SEM) baseline cardiac index (CI) and pulmonary artery diastolic pressure (PADP) were 1.7±0.11/ min/m2 and 30.5±4.1 mm Hg respectively. The mean % rise in CI was 78.8±23.3 and the mean % fall in PADP was 35.2±5.2. The mean half life of tolmesoxide in these patients was markedly prolonged at 15.6±6.6h. Side effects were minimal — vomiting was seen in 1 patient. This agent warrants further study in the long term management of refractory cardiac failure.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Planta 132 (1976), S. 1-8 
    ISSN: 1432-2048
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The cytokinins present in the spring sap of Acer pseudoplatanus L. were investigated. Ribosyl-trans-zeatin, trans-zeatin and dihydrozeatin were isolated and identified by combined gas chromatography-mass spectrometry (GC-MS). A number of other cytokinin active fractions were observed. One of these was less polar than zeatin and did not behave as any known cytokinin. Two other fractions were more polar than ribosylzeatin and were unstable. A decomposition product of one of these was identified as ribosyl-trans-zeatin by GC-MS. The possible nature of the unstable compounds is discussed. Data on the changes in cytokinin activity of the various fractions during spring 1973 are presented and discussed.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twelve kidneys which had a non-obstructed duplication anomaly on excretory urography were studied sonographically. Ten of the twelve kidneys had a single central renal sinus echo complex; only two kidneys had a split sinus complex typical of duplication. Sonography is not a reliable technique to identify a nonobstructed duplication anomaly.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Software quality journal 8 (1999), S. 241-253 
    ISSN: 1573-1367
    Keywords: software architectural specification ; coverage testing ; testing tool ; χSuds ; Specification and Description Language (SDL)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Available statistical data shows that the cost of repairing software faults rises dramatically in later development stages. In particular, the new technology of generating implementation code from architectural specifications requires highly reliable designs. Much research has been done at this stage using verification and validation techniques to prove correctness in terms of certain properties. A prominent approach of this category is model checking (Atlee, J.M., and Gannon, J. 1993. State-based model checking of event-driven systems requirements. IEEE Trans. Software Eng., 19(1): 24–40.) Such approaches and the approach of software testing are complementary. Testing reveals some errors that cannot be easily identified through verification, and vice versa. This paper presents the technology and the accompanying tool suite to the testing of software architecture specifications. We apply our state-of-the-art technology in software coverage testing, program diagnosis and understanding to software architectural designs. Our technology is based on both the control flow and the data flow of the executable architectural specifications. It first generates a program flow diagram from the specification and then automatically analyses the coverage features of the diagram. It collects the corresponding flow data during the design simulation to be mapped to the flow diagram. The coverage information for the original specification is then obtained from the coverage information of the flow diagram. This technology has been used for C, C++, and Java, and has proven effective (Agrawal, H., Alberti, J., Li, J.J., et al. 1998. Mining system tests to aid software maintenance, IEEE Computer July, pp. 64–73.)
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1439-6327
    Keywords: Key words Psychological stress ; Tissue plasminogen activator ; Plasminogen activator inhibitor-1 ; Atherosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tissue plasminogen activator (tPA) promotes fibrinolysis, and impaired fibrinolysis is associated with atherosclerosis and thrombosis. Plasminogen activator inhibitor-1 (PAI-1) inhibits t-PA expression. The effects of acute laboratory stressors on tPA and tPA/PAI-1 complexes were assessed in a sample of 11 cardiac patients. Participants were randomly assigned to either a stress or relaxation condition at time 1, and the alternative condition at time 2. Blood samples were taken before (pre) and after (post) each session and participants completed a battery of psychological questionnaires. Two-way repeated-measures analysis of variance revealed a statistically significant decrease in tPA (P=0.01) and tPA-PAI-1 complexes (P=0.04) during the mental stress condition. Anger-in had a strong relationship to decreases in tPA/PAI-1 levels in the stress condition (r=0.68, P 〈 0.05). Relaxation had no significant effect on tPA and tPA/PAI-1 levels. These data suggest that decreased fibrinolysis mediates the relationship between mental stress and atherosclerosis.
    Type of Medium: Electronic Resource
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