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Cervical necrotizing fasciitis (1999)

Aimoni, C. ; Cilione, A. R. ; Grandi, E. ; [et al.]

Springer

European archives of oto-rhino-laryngology and head & neck 256 (1999), S. 510-513

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ISSN: 1434-4726

Keywords: Key words Necrotizing fasciitis ; Neck infections

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Necrotizing fasciitis is a severe soft tissue infection that results in necrosis of the fasciae and subcutaneous tissues; the infection can quickly prove fatal. Although involvement of the head and neck is rare, causes are usually odontogenic or pharyngeal but can also be insect bites, local trauma, burns or surgery. We present a clinical case of a 31-year-old Italian woman with cervical necrotizing fasciitis having an uncommon presentation. While under treatment, the patient’s husband was admitted for necrotizing fasciitis of the medial fasciae of his left leg subsequent to an insect sting. The causes, diagnosis and treatment of necrotizing fasciitis are reviewed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004050050201

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Soft agonist receptor interactions: Theoretical and experimental simulation of the active site of the receptor of sweet molecules (1984)

Temussi, P. A. ; Lelj, F. ; Tancredi, T. ; [et al.]

New York, NY : Wiley-Blackwell

International Journal of Quantum Chemistry 26 (1984), S. 889-906

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ISSN: 0020-7608

Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The structure-activity relationship of sweet molecules is chosen as an example to illustrate a mechanistic approach of soft agonist-receptor interactions. It is shown that an essentially geometric model of the receptor site can explain the activity of most sweet molecules, both rigid and flexible. The relevant conformations of flexible molecules in solution are extracted from a combination of NMR data and of energy calculations. A possible experimental simulation of the receptor environment in solution is illustrated by the complex of a dipeptide sweetener with a crown-ether.

Additional Material: 8 Ill.