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  • Bone metabolism  (6)
  • Atomic force microscopy (AFM)  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Molecular imaging of Na^+,K^+-ATPase in purified kidney membranes
    Amsterdam : Elsevier
    FEBS Letters 346 (1994), S. 289-294 
    Details
    ISSN: 0014-5793
    Keywords: Atomic force microscopy (AFM) ; Ca^2^+- ATPase ; Ion pump ; Kidney membrane ; Membrane lipid ; Na^+,K^+-ATPase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-5793(94)00448-X
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of zinc-chelating dipeptide on bone metabolism in weanling rats: Comparison with β-alanyl-l-histidinato zinc-related compounds
    Amsterdam : Elsevier
    Peptides 15 (1994), S. 671-673 
    Details
    ISSN: 0196-9781
    Keywords: Bone metabolism ; Rat femur ; Zinc ; β-Alanyl-l-histidinato zinc
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0196-9781(94)90094-9
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular imaging of Na^+,K^+-ATPase in purified kidney membranes
    Amsterdam : Elsevier
    FEBS Letters 346 (1994), S. 289-294 
    Details
    ISSN: 0014-5793
    Keywords: Atomic force microscopy (AFM) ; Ca^2^+- ATPase ; Ion pump ; Kidney membrane ; Membrane lipid ; Na^+,K^+-ATPase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)00448-X
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Zinc decrease and bone metabolism in the femoral-metaphyseal tissues of rats with skeletal unloading (1995)
    Springer
    Calcified tissue international 57 (1995), S. 218-223 
    Details
    ISSN: 1432-0827
    Keywords: Skeletal unloading ; Bone metabolism ; Zinc ; β-Alanyl-L-histidinato zinc ; Rat femur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Whether the decrease of zinc content in the femoral-metaphyseal tissues of rats with skeletal unloading is involved in the alteration of bone metabolism was investigated. Skeletal unloading was designed using the model of hindlimb suspension in rats. Animals were fed for 4 days with the unloading. The metaphyseal zinc content were significantly decreased by the unloading. Zinc accumulation in the metaphyseal tissues by a single oral administration of zinc sulfate (20 mg Zn/100 g body weight) was partially depressed by the unloading, although serum zinc concentration was higher than that in normal rats, suggesting an impaired movement of zinc from serum into bone tissues by the unloading. Skeletal unloading caused a significant decrease of alkaline phosphatase activity and deoxyribonucleic acid (DNA) content in the metaphyseal tissues. These decreases were completely restored by addition of zinc sulfate (10-4 M) or β-alanyl-L-histidinato zinc (AHZ; 10-5 M) in a culture medium with the metaphyseal tissues in vitro. The effects of zinc compounds were abolished by the presence of cycloheximide (10-8 M), suggesting that the zinc effect is based on a newly synthesized protein. Dipicolinate (10-4 and 10-5 M), a potent zinc-chelating agent, caused an appreciable decrease of zinc content and alkaline phosphatase activity in the metaphyseal tissues. This decrease was restored by zinc supplement. The present results suggest that the skeletal unloading-induced decrease of zinc content in the femoral-metaphyseal tissues plays a role in the deterioration of bone metabolism in the unloaded rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310262
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  • 5
    Electronic Resource
    Electronic Resource
    Preventive effect of zinc for toxic actions of germanium and selenium on bone metabolism in weanling rats (1987)
    Springer
    Research in experimental medicine 187 (1987), S. 395-400 
    Details
    ISSN: 1433-8580
    Keywords: Bone metabolism ; Germanium ; Selenium ; Zinc ; Rat femur ; Alkaline phosphatase ; DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The preventive effect of zinc for the toxicic actions of germanium and selenium on bone metabolism was investigated in the femoral diaphysis of weanling rats. Germanium tetrachloride (1.53–30.60 µmol Ge/100 g b.w.) and selenium tetrachloride (1.53–7.65 µmol Se/100 g) was administered orally for 3 days. The doses of 1.53 and 7.65 µmol Ge/100 g caused a significant increase in DNA content although alkaline phosphatase activity was not altered significantly. By the dose of 30.60 µmol Ge/100 g, both alkaline phosphatase activity and DNA content were decreased significantly. Administration of selenium (1.53 and 7.65 µmol/100 g) produced significantly decreases in alkaline phosphatase activity and DNA content. The decreases of the enzyme activity and DNA content caused by administration of germanium (30.60 µmol/100 g) and selenium (7.65 µmol/100 g) were prevented completely by simultaneous injection of zinc sulfate (7.65 µmol Zn/100 g) for 3 days. Administration of zinc also produced appreciable increase in alkaline phosphatase activity and DNA content. The present study indicates that germanium and selenium disturbs bone metabolism in weanling rats, and that this disturbance is reversed by zinc.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01855666
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of vanadium on bone metabolism in weanling rats: Zinc prevents the toxic effect of vanadium (1989)
    Springer
    Research in experimental medicine 189 (1989), S. 47-53 
    Details
    ISSN: 1433-8580
    Keywords: Bone metabolism ; Vanadium ; Zinc ; Rat femur ; Calcium ; Alkaline phosphatase ; DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of vanadium on bone metabolism was investigated in the femoral diaphysis of weanling rats. Vanadium pentoxide (1.0–20.0 µmol V/100g b.wt.) was administered orally for 3 days. The doses of 15.0 and 20.0 µmol V/100 g caused a significant increase in serum calcium concentration. Bone alkaline phosphatase activity was increased significantly by the doses of 1.0–20.0 µmol V/100g, while bone acid phosphatase activity was not altered significantly. Bone DNA content was increased significantly by the dose of 1.0–10.0 µmol V/100 g. Bone calcium content was not altered significantly by administration of vanadium. The increase in serum calcium concentration caused by administration of vanadium (20.0 µmol/100 g) was prevented completely by simultaneous injection of zinc sulfate (15.3 µmol Zn/100 g) for 3 days, although zinc alone did not have any effect. Administration of zinc (15.3 µmol/100g) produced an appreciable increase in bone alkaline phosphatase activity, DNA content, and calcium content. These increases were not enhanced significantly by simultaneous injection of vanadium (2.0 and 20.0 µmol V/100 g). The present study indicates that a comparatively low dose of vanadium may play a nutritional role in bone formation of weanling rats, and that zinc can prevent the relevation of the toxic effect of vanadium with higher doses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01856029
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of essential trace metals on bone metabolism in weanling rats: Comparison with zinc and other metals' actions (1986)
    Springer
    Research in experimental medicine 186 (1986), S. 337-342 
    Details
    ISSN: 1433-8580
    Keywords: Bone metabolism ; Zinc ; Essential trace metals ; Rat femur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of essential trace metals on bone metabolism was investigated in the femoral diaphysis of weanling rats. Oral administration of zinc (1.53–306 µmol/100 g body weight) for 3 days produced significant increases in alkaline phosphatase activity and DNA content. These biochemical indices were also increased by oral administration of chromium (III), cobalt, copper, manganese, and nickel with the dose of 1.53 µmol/100 g. With the dose of 15.3 µmol/100 g of above all metals, except zinc, the enzyme activity was significantly decreased in comparison with control, while DNA content was not decreased significantly. Moreover, the effect of zinc on alkaline phosphatase activity and DNA content was not enhanced by simultaneous administration of other metals (1.53 µmol/100 g). The present study indicates that, of the essential trace metals, zinc can effectively stimulate the bone growth and calcification with comparatively higher dose levels. This suggests a nutritional significance of zinc on bone growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852099
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  • 8
    Electronic Resource
    Electronic Resource
    Simulated weightlessness and bone metabolism: Decrease of alkaline phosphatase activity in the femoral diaphysis of rats (1989)
    Springer
    Research in experimental medicine 189 (1989), S. 9-14 
    Details
    ISSN: 1433-8580
    Keywords: Weightlessness ; Skeletal unloading ; Bone metabolism ; Alkaline phosphatase ; Rat femur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of simulated weightlessness on bone metabolism was investigated in the skeletal unloading for up to 9 days. The skeletal unloading was designed by using the model of hindlimb hang in rats. The food ingestion of rats with the skeletal unloading was not altered in comparison to that of normal rats. Calcium concentration in the serum was not significantly altered by the skeletal unloading for 9 days, while the serum inorganic phosphorus concentration was significantly decreased at 6 and 9 days. Calcium content in the femoral diaphysis was not altered by the skeletal unloading for 9 days. However, the activities of alkaline and acid phosphatases in the femoral diaphysis were markedly decreased by the skeletal unloading. The decrease in bone alkaline phosphatase activity was seen at 2 days with the skeletal unloading. The present results demonstrate that the skeletal unloading with hindlimb hang can induce the disorder of bone metabolism. This model is useful for studying the effects of simulated weightlessness on bone metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01856023
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