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  • 1
    Electronic Resource
    Electronic Resource
    Effect of FK506 eye drops on late and delayed-type responses in ocular allergy models (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 33 (2003), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background It is well-known that FK506 strongly inhibits cytokine production by T cells in vitro. However, less evidence is available from in vivo studies of ocular allergy.Objective To study the anti-inflammatory effect of FK506 eye drops on late and delayed-type responses in several animal models of ocular allergy.Methods Rats and guinea-pigs were sensitized with egg albumin (EA) in adjuvant and later challenged by topical EA application to their eyes to examine the late response. Biopsy specimens of conjunctiva were stained with haematoxylin–eosin or stained for T cells and eosinophils. In addition, rats, rabbits and guinea-pigs were sensitized with complete Freund's adjuvant and later challenged by injecting purified protein derivatives for the delayed-type response. Bulbar conjunctival oedema and hyperaemia were graded by score in rabbits, and Evans blue (EB) extravasation was measured in rats and guinea-pigs. FK506 (0.01–1%) and steroid (0.1%) eye drops were instilled in the eyes of animals several times, before and after challenge.Results FK506 eye drops inhibited T cell and eosinophil infiltration in the late response and EB extravasation in the delayed-type response in rats. Also, they inhibited conjunctival oedema, hyperaemia and ocular mucus in the delayed-type response in rabbits. These effects were similar to those of steroid eye drops (betamethasone sodium phosphate, fluorometholone). FK506 eye drops also inhibited inflammatory cell infiltration, the loss of conjunctival epithelium and decrease of goblet cells in the late response as well as EB extravasation in the delayed-type response in guineapigs, a steroid-resistant species.Conclusion FK506 eye drops inhibit late and delayed-type responses in animal models of ocular allergy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2003.01698.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of zinc-chelating dipeptide on bone metabolism in weanling rats: Comparison with β-alanyl-l-histidinato zinc-related compounds
    Amsterdam : Elsevier
    Peptides 15 (1994), S. 671-673 
    Details
    ISSN: 0196-9781
    Keywords: Bone metabolism ; Rat femur ; Zinc ; β-Alanyl-l-histidinato zinc
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0196-9781(94)90094-9
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of zinc-chelating dipeptides on osteoblastic MC3T3-E1 cells: Activation of aminoacyl-tRNA synthetase
    Amsterdam : Elsevier
    Peptides 15 (1994), S. 1367-1371 
    Details
    ISSN: 0196-9781
    Keywords: Aminoacyl-tRNA synthetase ; Bone formation ; Chemical structure ; Osteoblasts ; β-Alanyl-l-histidinato zinc
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0196-9781(94)90110-4
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  • 4
    Electronic Resource
    Electronic Resource
    A new experimental determination of the relationship between the Hall mobility and the hole concentration in heavily doped p-type silicon
    Amsterdam : Elsevier
    Solid State Electronics 31 (1988), S. 5-12 
    Details
    ISSN: 0038-1101
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0038-1101(88)90079-2
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  • 5
    Electronic Resource
    Electronic Resource
    Cretaceous high-temperature rapid loading and unloading in the Abukuma metamorphic terrane, Japan (1998)
    Oxford, UK : Blackwell Science Ltd.
    Journal of metamorphic geology 16 (1998), S. 0 
    Details
    ISSN: 1525-1314
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: The Cretaceous Abukuma metamorphic terrane consists of the oceanic Gosaisyo Series overthrust onto the terrigenous Takanuki Series. Although the dominant mineralogy defines one of the classic areas of andalusite–sillimanite type progressive metamorphism, there are several lines of evidence suggesting an earlier higher-pressure (up to c. 12 kbar) history of the Takanuki Series and the nearby Gosaisyo Series. These are: (1) the occurrence of rare although widespread relic kyanite in sillimanite+K-feldspar zone-grade pelitic rocks; (2) the high grossular content of garnet interiors (up to c. 30 mol %) overgrown by Ca-poor rims (c. 2 mol % grossular) in pelitic rocks containing Al2SiO5 minerals (sillimanite±relic kyanite±retrograde andalusite), plagioclase and quartz; (3) the occurrence of rutile as inclusions in garnet in pelitic rocks; and (4) the occurrence of relic corundum+almandine association in silica-poor and Al–Fe-rich rocks. Garnet in the Takanuki Series pelitic rocks commonly shows textural sector zoning and preserves growth zoning despite the high metamorphic grade, suggesting rapid changes in P–T  conditions and a relatively short duration of high-temperature conditions. Combined with radiometric dating, these observations suggest that the Abukuma sillimanite+K-feldspar zone-grade rocks underwent a clockwise P–T  path with very fast (〉4 mm y−1) average burial and exhumation rates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1525-1314.1998.00065.x
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  • 6
    Electronic Resource
    Electronic Resource
    Fatigue-creep life prediction of 214Cr-1Mo steel under combined tension-torsion at 600^oC
    Amsterdam : Elsevier
    Nuclear Engineering and Design 150 (1994), S. 119-127 
    Details
    ISSN: 0029-5493
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0029-5493(94)90056-6
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  • 7
    Electronic Resource
    Electronic Resource
    Differential effects of insulin and insulin-like growth factor-I in the femoral tissues of rats with skeletal unloading (1994)
    Springer
    Calcified tissue international 55 (1994), S. 363-367 
    Details
    ISSN: 1432-0827
    Keywords: Skeletal unloading ; Bone formation ; Insulin ; Insulin-like growth factor-I ; Rat femur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract The alteration of bone metabolism in the femur of rats with skeletal unloading for 4 days was investigated. Skeletal unloading was designed using the model of hindlimb hang in rats. Skeletal unloading caused a significant decrease in femoral weight, calcium, and phosphorus contents in the metaphysis but not diaphysis. Also, the unloading induced a significant decrease of zinc content, alkaline phosphatase activity, and deoxyribonucleic acid (DNA) content in the femoral diaphysis and metaphysis. When the femoraldiaphyseal and metaphyseal tissues from normal and skeletal-unloading rats were cultured in the presence of insulin (10-9 and 10-8 M) for 24 hours in vitro, the hormonal effect to increase alkaline phosphatase activity and DNA content in the diaphysis, but not metaphysis, was lost in the bone tissues from unloading rats. However, the culture with insulin-like growth factor-I (IGF-I; 10-8 and 10-7 M) produced a significant increase of alkaline phosphatase activity and DNA content in both the diaphyseal and metaphyseal tissues from normal and unloading rats. These results demonstrate that skeletal unloading causes an impairment of insulin effect, but not IGF-I effect, on bone metabolism in femoral tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299316
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  • 8
    Electronic Resource
    Electronic Resource
    Functional neurokinin NK-1 receptor expression in rat peritoneal mast cells (1999)
    Springer
    Inflammation research 48 (1999), S. 274-279 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Mast cell — Substance P — NK-1 receptor — Histamine release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: Recently, Ogawa et al. [17] reported that the peritoneal mast cells (PMCs) of rats can release histamine by substance P (SP) in a receptor-dependent manner. In the present study, we confirmed and extended their findings.¶Material: PMCs were isolated from six strains of rats. In some experiments, peritoneal cells in the non-MC fraction were used.¶Methods: PMCs were incubated with SP, neurokinin (NK) receptor agonists or antagonists, and histamine content in the supernatant was measured. In the binding assay, PMCs were incubated with [125I]BH-SP together with SP or NK receptor antagonists. NK-1 receptor mRNA was detected using a reverse transcription-polymerase chain reaction (RT-PCR) assay.¶Results: PMCs from Slc:Wistar and F344/NSlc were highly sensitive to SP, leading to histamine release, whereas those from Slc:SD and three other strains were not. PMCs from Slc:Wistar and F344/NSlc also released histamine in the presence of an NK-1 agonist. The histamine release induced by SP and the NK-1 agonist was inhibited by the NK-1 receptor antagonists, FK888 and CP-99,994. [125I]BH-SP binding experiments revealed that PMCs from Slc:Wistar rats possessed a single high affinity binding site for SP and that the binding was blocked by NK-1 receptor antagonists. Peritoneal cells in the non-MC fraction exhibited no appreciable binding. In the RT-PCR assay, expression of NK-1 receptor mRNA was evident in Slc:Wistar PMCs, but not in the non-MC fraction from Slc:Wistar or Slc:SD PMCs.¶Conclusion: These data demonstrate the existence of functional NK-1 receptors on freshly isolated PMCs in at least some strains of rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050459
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  • 9
    Electronic Resource
    Electronic Resource
    Epivascular glia and paravascular holes in normal human retina (1986)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 224 (1986), S. 124-130 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the retinal surface of 28 autopsy eyes by scanning electron microscopy (SEM). Glialike cells or their processes, arranged in rows, were observed along retinal vessels in 22 eyes. Additionally, there were clusters of glialike cells over retinal vessels in 8 eyes. These proliferations ranged from focal to extensive ones, the latter resulting in distinct preretinal membranes. Focal defects of the superficial retina along the vessel were noted in 6 of 28 eyes. Transmission electron microscopic study in 2 surgically enucleated eyes with normal retinae revealed epivascular retinal degeneration and thinning of Müller cells. Glial processes appeared to be covering the defect of the internal limiting membrane and some projections of these cells continued inwards. These findings were consistent with the SEM findings of epivascular glialike structure. Our conclusions are that epivascular glialike structures and paravascular surface defects appear as a common finding in normal senile eyes, and that occasionally membranous formations arise from the epivascular area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02141484
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  • 10
    Electronic Resource
    Electronic Resource
    Fas ligand-mediated depletion of CD4 and CD8 lymphocytesby monomeric HIV-1-gp120 (1997)
    Springer
    Archives of virology 142 (1997), S. 1771-1785 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  In order to determine in what condition and by what mechanism gp 120 can deplete not only CD4 but also CD8 T cells, an in vitro system was established in which peripheral blood lymphocytes from healthy donors were treated with recombinant gp 120. We found that gp 120 can deplete both CD4 and CD8 T cells when they have recently been activated and are exposed to IL-2-deficient conditions. Bioassay of the Fas ligand (FasL) demonstrated augmented expression and release of soluble FasL by CD4 T cells in the supernatant of this culture. The administration of anti-FasL mAb and anti-Fas mAb, both of which exhibit neutralizing activity, completely abolished the depletion of these two T cell populations in culture. Based on these findings, we concluded that FasL depletes Fas antigen expressing CD4 and CD8 T cells by programmed cell death.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050050196
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