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  • Skeletal unloading  (4)
  • Atomic force microscopy (AFM)  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Molecular imaging of Na^+,K^+-ATPase in purified kidney membranes
    Amsterdam : Elsevier
    FEBS Letters 346 (1994), S. 289-294 
    Details
    ISSN: 0014-5793
    Keywords: Atomic force microscopy (AFM) ; Ca^2^+- ATPase ; Ion pump ; Kidney membrane ; Membrane lipid ; Na^+,K^+-ATPase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-5793(94)00448-X
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular imaging of Na^+,K^+-ATPase in purified kidney membranes
    Amsterdam : Elsevier
    FEBS Letters 346 (1994), S. 289-294 
    Details
    ISSN: 0014-5793
    Keywords: Atomic force microscopy (AFM) ; Ca^2^+- ATPase ; Ion pump ; Kidney membrane ; Membrane lipid ; Na^+,K^+-ATPase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)00448-X
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Differential effects of insulin and insulin-like growth factor-I in the femoral tissues of rats with skeletal unloading (1994)
    Springer
    Calcified tissue international 55 (1994), S. 363-367 
    Details
    ISSN: 1432-0827
    Keywords: Skeletal unloading ; Bone formation ; Insulin ; Insulin-like growth factor-I ; Rat femur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract The alteration of bone metabolism in the femur of rats with skeletal unloading for 4 days was investigated. Skeletal unloading was designed using the model of hindlimb hang in rats. Skeletal unloading caused a significant decrease in femoral weight, calcium, and phosphorus contents in the metaphysis but not diaphysis. Also, the unloading induced a significant decrease of zinc content, alkaline phosphatase activity, and deoxyribonucleic acid (DNA) content in the femoral diaphysis and metaphysis. When the femoraldiaphyseal and metaphyseal tissues from normal and skeletal-unloading rats were cultured in the presence of insulin (10-9 and 10-8 M) for 24 hours in vitro, the hormonal effect to increase alkaline phosphatase activity and DNA content in the diaphysis, but not metaphysis, was lost in the bone tissues from unloading rats. However, the culture with insulin-like growth factor-I (IGF-I; 10-8 and 10-7 M) produced a significant increase of alkaline phosphatase activity and DNA content in both the diaphyseal and metaphyseal tissues from normal and unloading rats. These results demonstrate that skeletal unloading causes an impairment of insulin effect, but not IGF-I effect, on bone metabolism in femoral tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299316
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Zinc decrease and bone metabolism in the femoral-metaphyseal tissues of rats with skeletal unloading (1995)
    Springer
    Calcified tissue international 57 (1995), S. 218-223 
    Details
    ISSN: 1432-0827
    Keywords: Skeletal unloading ; Bone metabolism ; Zinc ; β-Alanyl-L-histidinato zinc ; Rat femur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Whether the decrease of zinc content in the femoral-metaphyseal tissues of rats with skeletal unloading is involved in the alteration of bone metabolism was investigated. Skeletal unloading was designed using the model of hindlimb suspension in rats. Animals were fed for 4 days with the unloading. The metaphyseal zinc content were significantly decreased by the unloading. Zinc accumulation in the metaphyseal tissues by a single oral administration of zinc sulfate (20 mg Zn/100 g body weight) was partially depressed by the unloading, although serum zinc concentration was higher than that in normal rats, suggesting an impaired movement of zinc from serum into bone tissues by the unloading. Skeletal unloading caused a significant decrease of alkaline phosphatase activity and deoxyribonucleic acid (DNA) content in the metaphyseal tissues. These decreases were completely restored by addition of zinc sulfate (10-4 M) or β-alanyl-L-histidinato zinc (AHZ; 10-5 M) in a culture medium with the metaphyseal tissues in vitro. The effects of zinc compounds were abolished by the presence of cycloheximide (10-8 M), suggesting that the zinc effect is based on a newly synthesized protein. Dipicolinate (10-4 and 10-5 M), a potent zinc-chelating agent, caused an appreciable decrease of zinc content and alkaline phosphatase activity in the metaphyseal tissues. This decrease was restored by zinc supplement. The present results suggest that the skeletal unloading-induced decrease of zinc content in the femoral-metaphyseal tissues plays a role in the deterioration of bone metabolism in the unloaded rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310262
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Simulated weightlessness and bone metabolism: Decreases of protein and DNA syntheses in the femoral diaphysis of rats (1989)
    Springer
    Research in experimental medicine 189 (1989), S. 331-337 
    Details
    ISSN: 1433-8580
    Keywords: Weightlessness ; Skeletal unloading ; Bone protein synthesis ; Bone DNA synthesis ; Rat femur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of simulated weightlessness on bone protein and DNA syntheses was investigated in the skeletal unloading for up to 4 days. The skeletal unloading was designed by using the model of hindlimb hang in rats. The femoral-diaphyseal fragments obtained from rats which bred with skeletal unloading were cultured for 3 h at 37°C in 5% CO2/95% air in Dulbecco's Modified Eagle Medium (high glucose). When the bone tissues were pulsed with [3H]proline, the incorporation of [3H]proline into the bone protein was significantly decreased by skeletal unloading. In the pulse with [14C]uridine, the incorporation of [14C]uridine into the bone RNA was significantly reduced by skeletal unloading. Moreover, the incorporation of [3H]thymidine into the acid-insoluble residues of bone tissue was significantly decreased by skeletal unloading. Also, DNA content in the femoral diaphysis was significantly reduced by skeletal unloading. These findings suggest that skeletal unloading causes the decreases of protein and DNA syntheses in the femoral diaphysis of rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01855038
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Simulated weightlessness and bone metabolism: Decrease of alkaline phosphatase activity in the femoral diaphysis of rats (1989)
    Springer
    Research in experimental medicine 189 (1989), S. 9-14 
    Details
    ISSN: 1433-8580
    Keywords: Weightlessness ; Skeletal unloading ; Bone metabolism ; Alkaline phosphatase ; Rat femur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of simulated weightlessness on bone metabolism was investigated in the skeletal unloading for up to 9 days. The skeletal unloading was designed by using the model of hindlimb hang in rats. The food ingestion of rats with the skeletal unloading was not altered in comparison to that of normal rats. Calcium concentration in the serum was not significantly altered by the skeletal unloading for 9 days, while the serum inorganic phosphorus concentration was significantly decreased at 6 and 9 days. Calcium content in the femoral diaphysis was not altered by the skeletal unloading for 9 days. However, the activities of alkaline and acid phosphatases in the femoral diaphysis were markedly decreased by the skeletal unloading. The decrease in bone alkaline phosphatase activity was seen at 2 days with the skeletal unloading. The present results demonstrate that the skeletal unloading with hindlimb hang can induce the disorder of bone metabolism. This model is useful for studying the effects of simulated weightlessness on bone metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01856023
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    Paper (German National Licenses)
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