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  • 1
    Electronic Resource
    Electronic Resource
    Association of hepatitis C virus infection with chronic liver disease in paediatric cancer patients (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 490-492 
    Details
    ISSN: 1432-1076
    Keywords: Cancer ; Leukaemia ; Hepatitis ; Hepatitis-C virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 203 paediatric cancer treatment survivors were tested for serum antibodies against hepatitis-C virus (anti-HCV). Anti-HCV was detected in 41 patients (20.2%) with first generation anti-HCV ELISA. Positive results were confirmed in all samples retested with a second generation ELISA (n=35) and in all but two cases re-analysed by immunoblotting (n=23). Anti-HCV positive children had received significantly more blood product transfusions compared to seronegative patients. In 75 children (32%) chronic liver disease was found. It was defined as an elevation of serum alanine aminotransferase values to a least 2.5 times the upper limit of normal persisting for 6 months or longer. Hepatitis A was never detected, and in 58 children the chronic hepatopathy was unexplained by hepatitits B (non-A non-B chronic liver disease). Of these patients 29 (50%) were seropositive for anti-HCV. Surprisingly, non-A/non-B chronic liver disease was associated with anti-HCV in 14 of 19 solid tumour patients (78.9%), but in no more than 14 of 39 leukaemia and lymphoma patients (35.9%). This phenomenon was not explained by different rates of cytomegalovirus disease and drug toxicity related hepatopathies between the two groups. It may be related to differences of leukaemia/lymphoma compared to solid tumour therapy schedules (differential immuno-suppression and liver toxicity).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955056
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cold haemagglutinin disease complicatingMycoplasma pneumoniae infection in a child under cytotoxic cancer treatment (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 435-437 
    Details
    ISSN: 1432-1076
    Keywords: Cold agglutinin disease ; Auto-immune haemolytic anaemia ; Childhood cancer ; Immunosuppression ; Mycoplasma pneumoniae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute cold haemagglutinin disease, most commonly associated with underlying mycoplasma infection, is rare in children. A 3-year-old girl who developed this auto-immune disease under intensive cytotoxic treatment for rhabdomyosarcoma is presented. Clinically, a livedo reticularis skin pattern upon exposure to cold which was reversible at room temperature and a spontaneous red cell agglutination of blood samples in vitro led to the diagnosis. Together with bronchopneumonia the girl developed hyper-IgM, high antibody titres againstMycoplasma pneumoniae, as well as high titres of cold agglutinins. Laboratory signs of mild intravascular haemolysis were found. Positive direct antiglobulin test resulted from coating of red cells with C3d and C4. Three different antibodies were identified in serum: nonspecific cold agglutinins without complement activation, anti-I specific cold agglutinins with complement activation, as well as a weak biphasic Donath-Landsteiner haemolysin. Under antibiotic treatment and a short course of predisolone the clinical course was mild.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959358
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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