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  • Avian ADH  (1)
  • Brain stem  (1)
  • Diabetes insipidus  (1)
  • 1
    ISSN: 1432-0568
    Keywords: Neurosecretion ; Adrenalectomy ; Diabetes insipidus ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of adrenalectomy on the amount of “Gomori-positive” neurosecretory material in the outer layer of the median eminence and in the supraoptico-hypophysial system was studied in normal Long-Evans rats and in Long-Evans rats heterozygous and homozygous for hypothalamic diabetes insipidus. In all non-adrenalectomized rats very few “Gomori-positive” granules were found in the outer median eminence layer. After adrenalectomy the amount of the granules increased markedly in normal Long-Evans rats and only slightly in Long-Evans rats heterozygous for diabetes insipidus. However, no augmentation of the granules occurred in homozygous diabetes insipidus rats. The amount of “Gomori-positive” substances demonstrable in the supraoptic and paraventricular nuclei, in the inner layer of the median eminence, and in the neural lobe of the hypophysis was less in rats heterozygous for diabetes insipidus than in normal Long-Evans rats and the smallest in homozygous diabetes insipidus rats. No differences in the amounts of the substances were observed between adrenalectomized and non-adrenalectomized animals. The findings suggest that the “Gomori-positive” granules occurring in the outer layer of the median eminence of adrenalectomized rats are of similar origin as those of the supraoptico-hypophysial system and represent a vasopressin-neurophysin-complex. The results support the concept that vasopressin is involved in the regulation of ACTH release.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2013
    Keywords: Avian ADH ; Avian osmoregulation ; Cerebral osmosensitivity ; Hypothalamic temperature ; Vagal afferents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In conscious Pekin ducks adapted either to fresh water or to hypertonic saline (1.9%) as drinking fluid, urinary excretion, salt gland secretion and the serum concentration of radioimmunoassayable arginine-vasotocin (AVT) were examined with regard to their afferent and central control. The experiments were carried out under conditions of water diuresis, osmotic diuresis or supraorbital salt gland secretion, which were induced by continuous infusions of appropriate solutions. Temporary bilateral vagus blockade caused rises in AVT serum concentration accompanied by antidiuresis in hydrated ducks and by inhibition of salt gland secretion in salt-stressed ducks. Rostral brainstem cooling caused decreases of AVT serum concentration and water diuresis in ducks under osmotic diuresis and reduction of AVT serum concentration and inhibition of salt gland secretion in saltstressed ducks. Cerebral osmotic stimulation in hydrated ducks by intracarotid injection or by intracerebroventricular microinfusion of hypertonic NaCl solutions caused antidiuretic reactions associated with rises of AVT serum concentration.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 315 (1980), S. 83-84 
    ISSN: 1432-1912
    Keywords: Arginine vasopressin ; Brain stem ; Hypertensive rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The content of arginine vasopressin in the brain stem and neurohypophysis of adult spontaneously hypertensive rats was measured by radioimmunoassay and the values were compared to those measured in normotensive Wistar-Kyoto rats. In the brain stem of hypertensive rats, AVP content was decreased by 77% while neurohypophyseal AVP content was increased by 26%. The results demonstrate that brain stem AVP levels and neurohypophyseal AVP levels may change differentially and they are consistent with the possibility that brain stem AVP may be involved in altering cardiovascular reflex activity.
    Type of Medium: Electronic Resource
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