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  • 1
    Electronic Resource
    Electronic Resource
    Reluctance of rats to drink hashish suspensions: Free-choice and forced consumption, and the effects of hypothalamic stimulation (1974)
    Springer
    Psychopharmacology 35 (1974), S. 129-147 
    Details
    ISSN: 1432-2072
    Keywords: Cannabis ; Self-Administration of Drugs ; Ethanol ; Lateral Hypothalamus ; Electrical Stimulation of Brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract For over 30 days male Wistar rats drank a concentrated aqueous suspension of hashish in the absence of alternative fluids, but they rejected the drug when water was also made available. In another experiment rats given a choice between water and varying concentrations of hashish also rejected concentrated suspensions, but they appeared less reluctant to drink dilute concentrations. Neither a schedule of alternate-day presentation of hashish nor forced electrical stimulation of lateral hypothalamus induced rats to increase their home-cage intake of an aversive concentration of hashish, suggesting that the enhanced consumption of concentrated ethanol solutions obtained with these two procedures is not due to a nonspecific tendency to ingest any drug offered. Thus rats are generally reluctant to self-administer hashish via the oral route, and their reluctance is not affected by several procedures which can increase their intake of other drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429580
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Resistance to extinction of an avoidance response in rats following the administration of chlordiazepoxide (Librium) or diazepam (Valium) (1974)
    Springer
    Psychopharmacology 38 (1974), S. 231-238 
    Details
    ISSN: 1432-2072
    Keywords: Rat ; Chlordiazepoxide ; Diazepam ; Extinction ; Avoidance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a one-way avoidance task with rats, injections of Librium (chlordiazepoxide) following avoidance acquisition resulted in prolonged resistance-to-extinction of the avoidance response. This effect occurred regardless of whether the rats had had prior experience with Librium or whether they were naive with respect to the drug. The same results were found with the same task when low doses of Valium were used. However, at a higher dosage an “extreme reaction” of either no responding or a high number of responses to extinction occurred in the naive animals. The Librium and Valium effects were compared to similar effects obtained using ethanol and hashish resin. These results indicate that the novelty hypothesis as originally stated by Amit and Baum cannot be supported because experience with the drugs prior to avoidance training did not attenuate the drug effect on avoidance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421375
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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