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  • Schmidt-Lanterman incisures  (4)
  • Axon/Schwann Cell Relationship  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Schmidt-Lanterman incisures (1980)
    Springer
    Acta neuropathologica 52 (1980), S. 97-104 
    Details
    ISSN: 1432-0533
    Keywords: Schmidt-Lanterman incisures ; Sural nerve ; Remyelination ; Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A mechanism has been proposed previously for the formation of Schmidt-Lanterman incisures during ontogeny as myelinated nerve fibres increase in diameter. In this study, the mode of formation of incisures and their development were examined by light and electron microscopy in remyelinating fibres (16–200 d) of the sural nerve of rats following lysophosphatidyl choline (LPC)-induced segmental demyelination. In remyelination, a basic number of incisures is incorporated into the myelin sheath ab initio. Apparently these incisures which are at first circumferentially incomplete, being localised to the region of the mesaxons, progressively extend around the whole circumference of the myelin sheath. As fibre diameter increases, additional incisures are added, seemingly, by the intrusion of Schwann cell cytoplasm between the compact myelin lamellae, from the abaxonal side of the myelin sheath. The progressive differentiation of incisures is described in terms of their complement of organelles. The results are discussed with reference to the possible functions of incisures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688006
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The role of Schmidt-Lanterman incisures in Wallerian degeneration (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 95-103 
    Details
    ISSN: 1432-0533
    Keywords: Schmidt-Lanterman incisures ; Electron microscopy ; Nerve crush ; Wallerian degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The electron microscopy of changes at Schmidt-Lanterman incisures in Wallerian degeneration has been described only briefly previously. We have demonstrated that the changes up to 36 h after nerve crush are chiefly peri-incisural. At 12h and 24h ‘incisural dilatation’ consisted of an intraperiod line separation of peri-incisural myelin lamellae, which began among inner (adaxonal) lamellae extending later to outer (abaxonal) lamellae. The incisure itself showed little or no change. At 36 h, ovoid formation was apparent in most fibres. The sites of fibre cleavage to form ovoids occurred adjacent to incisures at the focal regions of myelin lamellae separation. Even within ovoids the incisures themselves remained intact at 36 h. The fine structural changes at incisures following nerve crush provide an understanding of the increased perceptibility of incisures by light microscopy during early Wallerian degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691150
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Schmidt-Lanterman incisures (1980)
    Springer
    Acta neuropathologica 52 (1980), S. 85-95 
    Details
    ISSN: 1432-0533
    Keywords: Schmidt-Lanterman incisures ; Teased fibres ; Remyelination, quantitative
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The quantitative relationship between the number of Schmidt-Lanterman incisures per internode and fibre diameter has been investigated previously in normal, developing, and regenerating fibres and from such data inferences have been made concerning the function of incisures. We have, therefore, examined this quantitative relationship in remyelinating fibres and assessed the implications for incisural function. Using the rat sural nerve, demyelination was induced by local microinjection of lysophosphatidyl choline. At 100 days and 200 days post-injection remyelinating fibres together with normal control fibres were examined quantitatively for the distribution of Schmidt-Lanterman incisures and nodes of Ranvier. Regression lines relating the number of incisures per internode to fibre diameter showed a positive correlation and were not significantly different between the three groups of fibres. The results are compatible with those for normal, developing and regenerating fibres and support the hypothesis of a homeostatic mechanism controlling the number of incisures in relation to fibre diameter and myelin volume. However, in remyelinating fibres, as in regenerating fibres, there is a greater incisural frequency as a consequence of the short internodes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688005
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Filipin-sterol complexes at Schmidt-Lanterman incisures (1987)
    Springer
    Acta neuropathologica 72 (1987), S. 355-361 
    Details
    ISSN: 1432-0533
    Keywords: Filipin ; Cholesterol ; Schmidt-Lanterman incisures ; Myelin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Employing the freeze-fracture technique, the distribution of filipin-sterol complexes was determined for membranes of peripheral nerve myelin. A heterogeneous distribution of complexes was observed with the greatest abundance on membranes associated with the cytoplasmic channels of Schmidt-Lanterman and longitudinal incisures. In addition there was an irregular network of well-labelled membrane bands in compact myelin. The results are related to a possible role for these channels and bands in the biochemical turnover of cholesterol in myelin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687267
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    An ultrastructural analysis of remyelination following segmental demyelination (1972)
    Springer
    Acta neuropathologica 22 (1972), S. 333-344 
    Details
    ISSN: 1432-0533
    Keywords: Segmental Demyelination ; Remyelination ; Axon/Schwann Cell Relationship ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electron microscopic observations were made of early remyelination after segmental demyelination in experimental allergic neuritis (EAN) and experimental diphtheritic neuropathy. In EAN 71% of axons which had been demyelinated were invaginated each within a single Schwann cell; remyelination associated with this cellular relationship was in accordance with the spiral myelin concept, 29% of demyelinated axons in EAN were initially enveloped each by several Schwann cell processes and the associated mechanism of remyelination was by “tunication” resulting in a transient irregular distribution of myelin lamellae around the axon circumference. In diphtheritic neuropathy regeneration more closely paralleled development in ontogeny. 88% of demyelinated axons were invaginated each within one Schwann cell, only 12% of axons were each enveloped by more than one Schwann cell process. Early remyelination by tunication was not observed in diphtheritic neuropathy. Additional loosely associated Schwann cell processes lying within the “old” Schwann cell basement membrane occurred frequently in both experimental conditions. Schmidt-Lanterman clefts, “redundant” myelin, and “desmosomes” were observed in the sheaths of incipient remyelination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00809244
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    Paper (German National Licenses)
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