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  • 1
    ISSN: 1432-0428
    Keywords: Neonatal hypoglycemia ; hyperinsulinism ; leucine-sensitivity ; islet hyperplasia ; ultrastructure ; A ; B ; D and type IV cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Morphometric and ultrastructural studies were performed on biopsy material from the pancreas of an infant with severe leucine-sensitive hypoglycemia and hyperinsulinism, in whom no insulinoma had been found. Qualitatively many large B cells were observed within the pancreatic islets. Quantitatively an about two fold increase of islet tissue proportion (4.2%) was demonstrated, compared with controls of approximately the same age (1.8%). Differential islet cell counting revealed an increase in A1 cells whereas the percentage of A2 and B cells appeared to be unchanged. Ultrastructurally in addition to A, B, and D cells a fourth islet cell type was demonstrated in unusual frequency. Its general function and its particular significance for the hypoglycemic syndrome are unknown. The findings correspond well with recent observations on the islet cell system in cases of neonatal hypoglycemia with leucine-sensitivity and hyperinsulinism.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 53 (1975), S. 717-722 
    ISSN: 1432-1440
    Keywords: Kidney allotransplantation ; fibrinuria-split-product E-determination ; Allogene Nierentransplantation ; Fibrinurie ; Spaltprodukt E-Ausscheidung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Immunologische Untersuchungen zur Fibrinurie wurden an 80 Urinchargen von 10 allogen nierentransplantierten Patienten mit verschiedenen Techniken durchgeführt. Das Fibrinogenspaltoprodukt E wurde dabei semiquantitativ durch zweidimensionale Immunoelektrophorese bestimmt. Während das Spaltprodukt E nicht mehr als etwa 10% des Gesamtgehalts aller Fibrinderivate im Harn ausmacht, konnte ein Anstieg bis zu 35% während schwerer akuter Abstoßungsreaktionen beobachtet werden. Auch während der ersten 2 – 3 Wochen nach der Transplantation, in denen die Fibrinurie kein Indiz einer drohenden Abstoßungskrise darstellt, kann durch die vermehrte Spaltprodukt E-Ausscheidung auch während dieses Zeitraumes ein diagnostischer Hinweis für eine drohende Abstoßungsreaktion erhalten werden.
    Notes: Summary 80 urine samples from 10 kidney grafted patients were immunologically analyzed for detection of fibrin degradation products by various techniques. Split product E, which was quantitatively determined by two-dimensional immunoelectrophoresis only contributes to a minor part to fibrinuria, but increases significantly during periods of severe acute rejection also during the first 2 – 3 weeks, when overall fibrinuria is not a useful indicator of impending rejection. Determination of split-product E therefore seems to be a valuable diagnostic procedure.
    Type of Medium: Electronic Resource
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