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  • 1
    Electronic Resource
    Electronic Resource
    Bone morphogenetic proteins and skeletal development: the kidney-bone connection (2000)
    Springer
    Pediatric nephrology 14 (2000), S. 598-601 
    Details
    ISSN: 1432-198X
    Keywords: Key words Morphogens ; Cytokines ; Cartilage ; BMP receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The bone morphogenetic proteins (BMPs) are a family of pleiotropic morphogens isolated and cloned from the demineralized extracellular matrix of bone. BMPs and related cartilage-derived morphogenetic proteins (CDMPs) initiate, promote and maintain bone and cartilage. The pleiotropic effects of BMPs are based on concentration-dependent thresholds. Targeted disruption of gene action by homologous recombination has demonstrated the role of BMP 7 in kidney, eye and skeletal development. BMP 7 is critical for kidney tubulogenesis, retinal pigmented epithelium differentiation and skeletal pattern. BMP 7 is also synthesized by the kidney and is detectable in serum; hence BMP 7 is both an autocrine and endocrine morphogen. It is likely renal BMP 7 may influence skeletal development and growth in children although there may be sources of other BMPs with skeletogenic actions. In conclusion, we are beginning to unravel the mysteries of kidney-bone connection with special reference to pediatric nephrology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670000364
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of estrogen and progesterone on matrix-induced endochondral bone formation (1983)
    Springer
    Calcified tissue international 35 (1983), S. 609-614 
    Details
    ISSN: 1432-0827
    Keywords: Matrix-induced endochondral bone formation ; Estradiol and progesterone ; Ornithine decarboxylase ; Mesenchymal cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The influence of estradiol and progesterone, alone or in combination, on the discrete phases of matrix-induced endochondral bone formation was investigated. Administration of estradiol and progesterone in combination increased mesenchymal cell proliferation, as indicated by [3H] thymidine incorporaton into acid precipitable material. However, ornithine decarboxylase (ODC) activity was significantly suppressed by the combination of estradiol and progesterone. Also, this treatment did not influence the35SO4 incorporation into proteoglycans on day 7. Mineralization of newly induced bone was quantitated by alkaline phosphatase,45Ca incorporation into bone mineral and calcium content, and was found to be significantly increased by progesterone alone and in combination with estradiol in both matrix-induced plaques and tibial metaphysis. These results demonstrated the stimulatory role of progesterone in combination with estradiol in bone formation and mineralization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405102
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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