ISSN:
1435-2451
Keywords:
Key words Tumor metastases
;
Angiogenesis
;
Anoikis
;
Tumor-host interaction
;
Immunologic escape
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Introduction: During the past decade, the molecular mechanisms in the process of tumor metastases and angiogenesis have become better understood. Discussion: The development of metastases requires complex molecular interactions in the detachment of tumor cells from solid tumors, the degradation of the extracellular matrix, escape from apoptosis, locomotion in the extracellular matrix, immunologic escape in the circulation, adhesion to endothelial cells, and extravasation from the circulation at the target site of metastasis and induction of angiogenesis. Conclusion: The increasing knowledge of these complex mechanisms offers new therapeutic approaches in the treatment of malignant diseases. This article will give an overview of the molecular mechanisms involved in the development of metastases and angiogenesis, and their clinical implications.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004230050183
Permalink
