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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    The international journal of advanced manufacturing technology 13 (1997), S. 77-85 
    ISSN: 1433-3015
    Keywords: Backlash ; Contouring accuracy ; Optimization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The paper describes a technique for the identification of and compensation for backlash on the contouring accuracy of computer numerically controlled (CNC) machining centres. A circular test that has been developed for rapidly checking the contouring accuracy of CNC machine tools is used to measure the contouring error due to backlash. Backlash error on the contouring profile is found as the direction of motion is reversed. A compensation strategy based on a simulated annealing (SA) optimisation algorithm is then developed to reduce the backlash error. Computational simulations and experimental tests have shown that the contouring error due to backlash can be greatly reduced by using this new approach.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0711
    Keywords: Key words Breast cancer ; Immunocytochemistry ; Tumor cell detection ; Leukapheresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We used a combination of 4 monoclonal antibodies (BM7, BM8 against MUC1, 5D3 aganist CK8,18,19 and HEA125 against human epithelial antigen) and a sensitive immunocytochemical staining using cytospin preparation to identify breast tumor cells in leukapheresis products (LP). This assay allowed detection of one tumor cell in 1×106 mononuclear cells (MC). In clinical specimens, tumor cells were detected in LP from 6 of 42 (14.3%) patients in the adjuvant treatment group, from 2 of 11 (18.2%) patients in the neoadjuvant treatment group and from 9 of 43 (20.1%) in the group of patients with metastatic disease. Tumor cell counts ranged from 0.25–5 cells in 1×106 normal cells per LP. The median tumor cell concentration was higher in specimens from patients with metastatic disease (median=0.96) than in specimens from patients in the adjuvant and neoadjuvant treament groups (median=0.5 and 0.75). No significant differences between the epithelial cell positive group and the epithelial cell negative group with respect to tumor size, lymph nodes involvement, tumor grade, histological type and receptor were found. We conclude that immunocytochemical staining of cytospin preparation is a sensitive and simple method to detect and quantitate breast cancer cells in LP.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 21 (1997), S. 15-42 
    ISSN: 0363-9061
    Keywords: variable permeability and shear modulus ; non-linear wave ; finite element model ; Engineering ; Civil and Mechanical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: Conventional investigations of waves-seabed interaction problems have been only concerned with the soil response due to two-dimensional linear progressive waves over a uniform seabed. However, the effects of non-linear waves which have been reported in the literature may be significantly different. In this paper, a finite element model is developed to investigate the non-linear wave-induced seabed response with variable permeability and shear modulus in a three-dimensional domain. The finite element formulations are fully presented in this paper. The numerical model is verified with the previous investigations through the reduced form of the present solution. The numerical results indicate that the influence of non-linear wave components cannot always be ignored without substantial error. Furthermore, the wave-induced seabed response is affected significantly by variable permeability in coarser seabeds and variable shear modulus in finer seabeds. © 1997 by John Wiley & Sons, Ltd.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
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