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  • 1
    Electronic Resource
    Electronic Resource
    Chromatographic solutions to pharmaceutical analytical problems (1992)
    Springer
    Chromatographia 34 (1992), S. 411-416 
    Details
    ISSN: 1612-1112
    Keywords: Ion-exchange chromatography ; Ion-pair reversed-phase chromatography ; Pharmaceutical analysis ; Baclofen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Chromatography plays a major role in pharmaceutical analysis since classic methods such as titrimetry or direct spectroscopic analyses do not provide sufficient selectivity and/or detectability. Of various chromatographic methods, HPLC offers good resolution and great versatility in handling compounds that are thermally unstable, polar, and non-volatile at low temperatures. Discussed in this paper is an example of a pharmaceutical compound viz. baclofen [4-amino-3-(p-chlorophenyl)butyric acid], a compound with low UV absorptivitiy, where HPLC provides the desired selectivity and detectability to allow precise determinations in the presence of pharmaceutical excipients. Discussed here also are investigations on mechanism of separations by ion-exchange and ion-pair reversed-phase chromatography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02268376
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    An autoradiography study of postoperatively labelled thyroid tissue and iodine storage (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 791-795 
    Details
    ISSN: 1619-7089
    Keywords: Human thyroid ; Iodine 125 autoradiography ; In vitro labelling of thyroid tissue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Samples of fresh thyroid tissue obtained from 15 patients undergoing thyroid surgery were incubated with iodine 125 in culture solution to which thyroid-stimulating hormone (TSH) had been added and then examined by autoradiography. The radioactivity registered actively during the 90-min incubation period was primarily found in the lumina of follicles. Even morphologically similar follicles showed very heterogeneous uptake of radioiodine; small follicles often contained the highest concentrations of activity. The method applied appears to be particularly useful for answering the question as to whether and to what extent individual papillary or follicular thyroid carcinomas are able to store radioiodine. This information obtained immediately after surgery may contribute towards establishing the patient's prognosis and help in deciding on postoperative therapy and follow-up. Because of the heterogeneity of radioiodine uptake, it is mandatory to examine a representative sample of carcinoma tissue in order to obtain well-established results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175056
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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