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  • Bacterial endotoxin  (1)
  • CT scanning  (1)
  • Chloroquine  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Stimulation of human fetal astrocyte proliferation by bacterial lipopolysaccharides and lipid A (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 384-388 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Bacterial endotoxin ; Lipopolysaccharide ; Lipid A ; Culture astrocyte
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary This report concerns the effect of bacterial endotoxin [lipopolysaccharide(LPS) and lipid A] on cultured human fetal astrocytes. Exposure to 1 μg/ml LPS or lipd A caused a striking stimulation of the rate of proliferation of the cells. The effect was most pronounced with exponentially growing cultures. Stimulation was associated with enhance DNA synthesis as ascertained by [3H]thymidine incorporation. These findings at the cellular level may be of relevance in the elucidation of the effects of bacterial endotoxins on the developing human brain.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00296549
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Lysosomal glycosphingolipid storage in chloroquine-induced α-galactosidase-deficient human endothelial cells with transformation by simian virus 40: in vitro model of Fabry disease (1993)
    Springer
    Acta neuropathologica 85 (1993), S. 272-279 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Fabry disease ; Endothelial cells culture ; Simian virus 40 ; Transformation ; Chloroquine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Human umbilical venous endothelial cells were transformed with a temperature-sensitive mutant of simian virus 40, tsA640, and a cell line, subcultured for over 20 serial passages, was established at a temperature permissive for the virus. Treatment of transformed endothelium with 3μg/ml chloroquine caused a specific reduction of α-glactosidase activity, without cell injury, and revealed several electron-dense materials surrounded by single unit membranes. Crystalline lamellae in lysosomes with a periodicity of 6.5 nm, which are typically seen in various tissues in Fabry disease, were produced in the presence of a glycosphingolipid mixture. These cells should be useful for in vitro pathophysiological studies on Fabry endothelium.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00227722
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Computed tomography in Krabbe's disease: Comparison with neuropathology (1983)
    Springer
    Neuroradiology 25 (1983), S. 323-327 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Krabbe's disease ; CT scanning ; globoid cell leukodystrophy ; gliosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We report computed tomography (CT) appearance of two patients with Krabbe's disease. The most common findings included severe brain atrophy: an enlarged frontal extracerebral space, dilatation of ventricles, enlarged cisterns and enlarged cortical sulci. There was low attenuation in the corpus medullaris of the cerebellum, and symmetrical focal hypodensity in the central periventricular white matter. CT at the terminal stage (16 months) showed marked cerebral atrophy including flattening of the heads of caudate nuclei and widening of the third ventricles confirmed by a neuropathological study. There was relatively less low density on the white matter of Krabbe's disease compared with that of other leukodystrophies. These CT findings may be useful in the diagnosis. The relative lack of low density in the white matter of Krabbe's disease might be related to severe gliosis and reduced total lipid contents.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00439212
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