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  • Polyglucosan bodies  (4)
  • Hydrous zirconium oxide  (3)
  • Insulin receptor  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Insulin receptor gene mutation: A molecular genetical and funtional analysis
    Amsterdam : Elsevier
    Cellular Signalling 4 (1992), S. 351-363 
    Details
    ISSN: 0898-6568
    Keywords: Insulin receptor ; acanthosis nigricans ; insulin receptor gene ; insulin resistance ; leprechaunism ; non-insulin-dependent diabetes ; obesity ; pedigree analysis ; phosphorylation ; tyrosine kinase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0898-6568(92)90030-C
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  • 2
    Electronic Resource
    Electronic Resource
    Polyglucosan bodies in the digestive tract of the aged dog (1983)
    Springer
    Acta neuropathologica 60 (1983), S. 297-300 
    Details
    ISSN: 1432-0533
    Keywords: Polyglucosan bodies ; Lafora-like bodies ; Aging ; Smooth muscles ; Digestive tract ; Dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In our recent studies on aging phenomena in animals, polyglucosan bodies (PGB) were found within the smooth muscle in the digestive tract of aged dogs without neurologic signs. PGB were basophilic, round, or oval bodies which appeared to have a homogenous or concentric shape. Their histochemical properties were characterized by the presence of glucose polymers (polyglucosan). Electron microscopy revealed that PGB were composed mainly of irregularly clustered, short branching filaments measuring about 90 Å in width. PGB were histochemically and ultrastructurally identical to the previously reported Lafora-like bodies in the CNS of aged dogs. PGB were found in all aged dogs and were disseminated throughout the digestive tract, especially in the cecum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691880
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  • 3
    Electronic Resource
    Electronic Resource
    Immunoreactivity of canine and feline polyglucosan bodies for monoclonal antibody against human polyglucosan (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 217-218 
    Details
    ISSN: 1432-0533
    Keywords: Immunohistochemistry ; Polyglucosan bodies ; Dog ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary With the use of monoclonal antibodies, raised against the human polyglucosan, positive staining of polyglucosan bodies (PGB) was detected in the brain, spinal cord and cecum of aged dogs. PGB in feline brain were also positively stained with these antibodies. These findings indicate that animal PGB share common antigenicity with human PGB.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334511
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  • 4
    Electronic Resource
    Electronic Resource
    Polyglucosan bodies in the brain of a cow (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 75-77 
    Details
    ISSN: 1432-0533
    Keywords: Polyglucosan bodies ; Cow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Polyglucosan bodies (PGBs) in the brain of a 12-year-old Holstein cow exhibiting no signs of neurological abormality were examined by light and electron microscopy and immunohistochemistry. PGBs were disseminated throughout the brain, especially in the pallidum, thalamus and cerebellum. Cow PGBs were found in the neuronal perikaryon and in the neuropil. These were round, slightly to severely basophilic, and were strongly positive for the periodic acid-Schiff reaction. The cow PGBs were immunoreactive for monoclonal antibodies raised against human polyglucosan. Electron microscopic analysis revealed that they were composed of branching filaments, glycogen granules and electrondense meterial. These findings indicate that cow PGBs closely resemble human or canine PGBs in Lafora's disease and PGBs found in aged animals that have been reported previously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294362
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  • 5
    Electronic Resource
    Electronic Resource
    Lectin histochemistry of canine polyglucosan bodies (1987)
    Springer
    Acta neuropathologica 73 (1987), S. 177-180 
    Details
    ISSN: 1432-0533
    Keywords: Lectins ; Polyglucosan bodies ; Dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lectin histochemistry was investigated to identify sugar residues of the polyglucosan bodies of canine brain, spinal cord and caecum. The polyglucosan bodies in the brain and spinal cord stained with concanavalin A (ConA) but not with soybean agglutinin, wheat germ agglutinin, peanut agglutinin,Dolichos biflorus agglutinin,Ricinus communis agglutinin andUlex europaeus agglutinin. Caecum, polyglucosan bodies, however, did not stain with any of the seven lectins employed. After periodate oxidation, paradoxical ConA staining was observed in the polyglucosan bodies of the brain, spinal cord and caecum. These results indicate that polyglucosan bodies contain mannose and glucose residues and suggest that the component of polyglucosan bodies is partially derived from rough endoplasmic reticulum, the Golgi apparatus and hypolemmal cisternae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00693785
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  • 6
    Electronic Resource
    Electronic Resource
    Abnormal messenger ribonucleic acid (mRNA) transcribed from a mutant insulin receptor gene in a patient with type A insulin resistance (1992)
    Springer
    Diabetologia 35 (1992), S. 639-644 
    Details
    ISSN: 1432-0428
    Keywords: Insulin receptor ; type A insulin resistance ; deletion ; polymerase chain reaction ; insulin receptor gene ; direct sequence ; mRNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a previous report on a 16-year-old Japanese girl with type A insulin resistance, we found that one allele of the insulin receptor gene was inherited from her mother and contained a 1.2 kilobase pair deletion which removed the 14th exon in the β subunit. We extended investigation of the proband and found the deletion between two Alu sequences. To determine the effect of the deletion on the level of transcription and the splicing pattern of messenger ribonucleic acid (mRNA), we synthesized the complimentary DNA and used the polymerase chain reaction to amplify the region which included the deleted area. The deletion shifted the reading frame, resulting in a termination codon after amino acid 867 (Glu), thereby producing a truncated insulin receptor without a transmembrane region and cytoplasmic domain. We also sequenced each of 22 exons of the insulin receptor gene but found no mutation in exons of the insulin receptor gene, except for deletion of exon 14 of the maternal allele. Thus, the proband is a heterozygote for a single mutant allele. Abnormal mRNA transcribed from the mutant allele resulted in a decrease in insulin binding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400255
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  • 7
    Electronic Resource
    Electronic Resource
    Defects in insulin binding and receptor kinase in cells from a woman with type A insulin resistance and from her family (1991)
    Springer
    Diabetologia 34 (1991), S. 86-92 
    Details
    ISSN: 1432-0428
    Keywords: Insulin receptor ; type A syndrome of insulin resistance ; insulin binding ; autophosphorylation ; kinase activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Defects in insulin receptor function lead to impairment of the insulin response. We treated a patient with the typical phenotype of type A syndrome of insulin resistance whose insulin receptor seemed to lack the transmembrane region and cytoplasmic domain. Hyperinsulinaemia and resistance to exogenous insulin were evident, and insulin binding to cells and uptake of 2-deoxyglucose into fibroblasts were greatly decreased. Molecular weight of the α-subunit of the insulin receptor was normal, but autophosphorylation and kinase activity were impaired. In the pedigree analysis, defects in insulin binding were also observed in the mother, maternal grandfather and two maternal aunts, corresponding with the abnormality of the insulin receptor gene and mild insulin resistance. In the mother, much the same kinase defects as were seen in the patient became evident. However, no relatives had clinical symptoms similar to those seen in the patient. In the father there was a mild insulin resistance in the glucose clamp study and a borderline impaired glucose tolerance. Although insulin binding to cells was normal in the father, both autophosphorylation and kinase activity were reduced. Our findings suggest that insulin resistance in the patient may be caused by the defects in insulin receptor kinase activity as well as by a reduction in insulin binding activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500378
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  • 8
    Electronic Resource
    Electronic Resource
    Evaluation of hydrous zirconium oxide loaded porous polymer resin for ion chromatographic separation of carboxylic acids (1995)
    Springer
    Chromatographia 40 (1995), S. 577-580 
    Details
    ISSN: 1612-1112
    Keywords: Ion chromatography ; Hydrous zirconium oxide ; Porous polymer resin ; α-Hydroxyl carboxylic acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A porous polymer resin loaded with hydrous zirconium oxide (Zr-gel) was evaluated as a selective stationary phase for the ion chromatographic separation of carboxylic acids. We have found that Zr-gel has a specificity to the α-hydroxyl groups on carboxylic acids. Using 3×10−3 mol l−1 of sodium carbonate as a mobile phase, monocarboxylic acids such as formate, acetate, propionate and butyrate, were immediately eluted at the void volume of the Zr-gel column, whereas α-hydroxy-monocarboxylic acids such as glycolate and lactate were clearly retained. Dicarboxylic acids with an α-hydroxyl group, viz., malate and tartarate, were also strongly retained and not eluted from the Zr-gel column.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02290271
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  • 9
    Electronic Resource
    Electronic Resource
    Determination of the specific interaction of disubstituted aromatic compounds on hydrous zirconium oxide-loaded porous polymer resin (1996)
    Springer
    Chromatographia 42 (1996), S. 396-400 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Hydrous zirconium oxide ; Porous polymer resin ; Disubstituted phenols ; ortho-Benzoic acid derivatives
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A porous polymer resin loaded with hydrous zirconium oxide (Zr-gel) was evaluated as a stationary phase for the liquid chromatographic separation of disubstituted aromatic compounds. The prepared Zr-gel was used to separate disubstituted phenols andortho-substituted benzoic acid derivatives in reversed-phase mode. The retention time of catechol was greater than those of other disubstituted phenols; this implies that the Zr-gel has specificity for the phenolic hydroxyl group. The retention behavior ofortho-substituted benzoic acid derivatives on the Zr-gel was also evaluated in reversedphase mode using buffer. Phthalic acid was specifically retained in the vicinity of pH 6.0, which has been regarded as the equal adsorbic point. Similar behavior was also observed for salicylic acid, although the retention time of salicylic acid was less than that of phthalic acid. It seems that the specific retention behavior of hydrous zirconium oxide is a result of complexation with ligands such as hydroxyl and carboxyl groups. The results of this study have revealed that the retention mechanism of hydrous zirconium oxide is a combination of ion exchange and interaction based on complexation with ligands.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02272129
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  • 10
    Electronic Resource
    Electronic Resource
    Evaluation of the influence of the base material loaded with hydrous zirconium oxide gel on the retention behavior of disubstituted benzoic acids (1996)
    Springer
    Chromatographia 43 (1996), S. 79-81 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Hydrous zirconium oxide ; Porous polymer resin ; Silica gel ; ortho-Benzoic acid derivatives
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Silica gel loaded with hydrous zirconium oxide (Zr-gel-S) has been prepared and the influence of the base material on the retention behavior ofo-phthalic acid on the hydrous zirconium oxide was evaluated. The retention behavior of the acid on the Zr-gel-S was compared with that on Zr-gel-5, the polymer-based Zr-gel. Comparable retention behavior,i.e. maximum retention in the vicinity of pH 6, which has been regarded as the equal adsorbic point, was observed for both types of Zr-gel, although there was a large difference in the retention times. The difference in retention on the two types of Zr-gel could be ascribed to nature of the base material. The results in this experiments showed, however, that the specific behavior at pH 6 was an essential characteristic of hydrous zirconium oxide and was not related to the influence of the base materials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02272826
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