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  • Barbiturates  (2)
  • Dexetimide  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Differential antagonism by the anticholinergic dexetimide of inhibitory effects of haloperidol and fentanyl on brain self-stimulation (1975)
    Springer
    Psychopharmacology 41 (1975), S. 229-235 
    Details
    ISSN: 1432-2072
    Keywords: Haloperidol ; Fentanyl ; Dexetimide ; Brain Self-Stimulation ; Medial Forebrain Bundle ; Dopamine ; Neostriatum ; Antipsychotic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Haloperidol (0.08 mg/kg) or fentanyl (0.16 mg/kg) injected subcutaneously suppressed bar-pressing for brain-stimulation in rats, implanted with electrodes in the lateral hypothalamic area of the medial forebrain bundle. Increasing doses: 0.04, 0.16, 0.63 and 2.50 mg/kg of the central anticholinergic dexetimide gradually antagonized the haloperidol effects. The highest dose of dexetimide did not reduce the fentanyl-induced inhibition. The results, together with a literature survey on the anticholinergic effects on neuroleptic-induced catalepsy and inhibition of avoidance behavior, are related to biochemical findings and clinical effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428929
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of acute hypoxia on brain-sensitivity and metabolism of barbiturates in mice (1970)
    Springer
    Psychopharmacology 17 (1970), S. 193-197 
    Details
    ISSN: 1432-2072
    Keywords: Barbiturates ; Brain Sensitivity ; Hypoxia ; Pentobarbital Metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acute exposure of mice to hypobaric hypoxia, or reduced oxygen at normal pressure, markedly potentiated barbiturate-induced hypnosis. The mice showed lower body concentration of pentobarbital on awakening and reduced rate of pentobarbital disappearance from the body during exposure to the hypoxic environment. These data suggest that acute exposure to hypoxia depresses in vivo metabolism of pentobarbital and enhances CNS sensitivity to the barbiturates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402709
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Alterations in brain sensitivity and barbiturate metabolism unrelated to aggression in socially deprived mice (1970)
    Springer
    Psychopharmacology 18 (1970), S. 320-324 
    Details
    ISSN: 1432-2072
    Keywords: Barbiturates ; Brain Sensitivity ; Social Deprivation ; Hexobarbital Metabolism ; Aggression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Male and female mice deprived of social interactions showed increased resistance to hexobarbital narcosis. However, only the isolated males developed aggressiveness. The more rapid disappearance of hexobarbital from the whole body of isolated mice and the higher drug concentration at awakening in these animals indicate enhanced hepatic degradation with a concomitant increase in CNS excitability. Development of aggressiveness in isolated male mice did not correlate temporally with the reduced response to hexobarbital. These data suggest that alterations in barbiturate sensitivity and development of aggressiveness following social deprivation have different biological bases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412678
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of cholinergic agonists and antagonists on morphine-withdrawal syndrome (1976)
    Springer
    Psychopharmacology 49 (1976), S. 191-195 
    Details
    ISSN: 1432-2072
    Keywords: Pilocarpine ; Atropine ; Dexetimide ; Methylscopolamine ; Morphine addiction ; Narcotic withdrawal ; Aggression ; Wet shakes ; Diarrhea ; Dopamine ; Acetylcholine interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of pilocarpine, atropine and dexetimide were studied on the occurrence and intensity of morphine-withdrawal signs observed after cessation of chronic morphine injections. Pilocarpine was effective in reducing both ‘wet-dog’ like body shakes and aggression but it increased diarrhea and weight loss. Pretreatment with atropine blocked all of the effects of pilocarpine on withdrawal signs. Methylscopolamine pretreatment blocked only diarrhea. The administration of atropine or dexetimide produced no significant effect on any of the withdrawal signs. These results indicate a role for central cholinergic mechanism in narcotic withdrawal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427289
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    Paper (German National Licenses)
    Fulltext
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