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  • 1
    Electronic Resource
    Electronic Resource
    Effect of nitrazepam, amylobarbitone sodium and placebo on the electroencephalogram of normal subjects (1969)
    Springer
    Psychopharmacology 14 (1969), S. 178-183 
    Details
    ISSN: 1432-2072
    Keywords: Barbiturates ; Minor Tranquillizers ; Electroencephalography ; Benzodiazepines ; Sleep
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a balanced, fully crossed-over, double-blind investigation on healthy young adults, 5 mg and 10 mg of nitrazepam reduced parieto-occipital EEG activity more slowly but more markedly than 100 mg and 200 mg of sodium amylobarbitone. Differences between the drugs, but not between doses, were statistically significant. All four treatments differed significantly from placebo in respect of the level attained after sixty minutes. Differences in speed of onset were detected within six minutes of giving the drug by mouth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404215
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of nitrazepam, amylobarbitone and placebo on some perceptual, motor and cognitive tasks in normal subjects (1969)
    Springer
    Psychopharmacology 14 (1969), S. 167-177 
    Details
    ISSN: 1432-2072
    Keywords: Barbiturates ; Minor Tranquillizers ; Benzodiazepines ; After-Images ; Decision-Time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Some behavioural effects of placebo, 5 and 10 mg of nitrazepam and 100 and 200 mg of sodium amylobarbitone were compared in 10 healthy young subjects. Both doses of nitrazepam had a more pronounced effect upon measures of motor response time, decision time and digit symbol substitution than either dose of the barbiturate, but the effects of the benzodiazepine were probably diminishing at a time (150 min after drug administration) when those of the barbiturate were still increasing. Nitrazepam markedly increased the latency of after-image development and reduced its duration. There was a tendency for an increased information load to slow decision time more when subjects were treated with sodium amylobarbitone than with nitrazepam. Comparison of performance under placebo of subjects who did and did not sleep when treated with 10 mg nitrazepam suggested that the effects of this dose of the drug were predominantly hypnotic for the former and “tranquillizing” for the latter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404214
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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