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  • 1
    Electronic Resource
    Electronic Resource
    Gripes (1983)
    [s.l.] : Nature Publishing Group
    Nature 306 (1983), S. 726-726 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - I would like to add to your list of gripes (Nature 10 November 1983, p. 134) the use of such terms as "we are at present on a learning curve" (to describe any monotonic time series with negative regression) by writers who obviously are ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/306726c0
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  • 2
    Electronic Resource
    Electronic Resource
    Mendel's legacy remains untarnished (1987)
    [s.l.] : Nature Publishing Group
    Nature 326 (1987), S. 251-251 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR-Van Valen1 suggests that I share the widespread view that Mendel falsified some of his data2. In fact, I do not, though it is certainly the view of sources quoted by the author whose book I was reviewing3.1 plead guilty to having tried to save space but not to iconoclasm. It is doubtful, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/326251a0
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  • 3
    Electronic Resource
    Electronic Resource
    “To please or not to please” (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 157-159 
    Details
    ISSN: 1432-1041
    Keywords: placebo ; clinical trial ; ethics of experimentation ; drug efficacy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561893
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of fixed interval and visual analogue scales for rating chronic pain (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 415-420 
    Details
    ISSN: 1432-1041
    Keywords: Chronic pain ; self-rating ; visual analogue scale ; four-point scale
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A visual analogue scale (VAS) and a 4-point scale (FPS) have been compared in patients suffering from prolonged constant pain due to chronic inflammatory or degenerative arthropathy. Each patient was treated with a constant low or high dose of paracetamol or dihydrocodeine throughout a four week period. The VAS was accurate, as reliable and more sensitive than the FPS in registering the intensity of chronic pain. Separate records of each estimate, sealed immediately on completion by the patient, resulted in omission of significantly more pain recordings on the FPS, whereas retention by the patients of their previous records did not systematically influence subsequent judgments. In this study, the VAS appeared to be more satisfactory than the FPS for patient self-rating of pain intensity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562315
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of nitrazepam, amylobarbitone sodium and placebo on the electroencephalogram of normal subjects (1969)
    Springer
    Psychopharmacology 14 (1969), S. 178-183 
    Details
    ISSN: 1432-2072
    Keywords: Barbiturates ; Minor Tranquillizers ; Electroencephalography ; Benzodiazepines ; Sleep
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a balanced, fully crossed-over, double-blind investigation on healthy young adults, 5 mg and 10 mg of nitrazepam reduced parieto-occipital EEG activity more slowly but more markedly than 100 mg and 200 mg of sodium amylobarbitone. Differences between the drugs, but not between doses, were statistically significant. All four treatments differed significantly from placebo in respect of the level attained after sixty minutes. Differences in speed of onset were detected within six minutes of giving the drug by mouth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404215
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of nitrazepam, amylobarbitone and placebo on some perceptual, motor and cognitive tasks in normal subjects (1969)
    Springer
    Psychopharmacology 14 (1969), S. 167-177 
    Details
    ISSN: 1432-2072
    Keywords: Barbiturates ; Minor Tranquillizers ; Benzodiazepines ; After-Images ; Decision-Time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Some behavioural effects of placebo, 5 and 10 mg of nitrazepam and 100 and 200 mg of sodium amylobarbitone were compared in 10 healthy young subjects. Both doses of nitrazepam had a more pronounced effect upon measures of motor response time, decision time and digit symbol substitution than either dose of the barbiturate, but the effects of the benzodiazepine were probably diminishing at a time (150 min after drug administration) when those of the barbiturate were still increasing. Nitrazepam markedly increased the latency of after-image development and reduced its duration. There was a tendency for an increased information load to slow decision time more when subjects were treated with sodium amylobarbitone than with nitrazepam. Comparison of performance under placebo of subjects who did and did not sleep when treated with 10 mg nitrazepam suggested that the effects of this dose of the drug were predominantly hypnotic for the former and “tranquillizing” for the latter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404214
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  • 7
    Electronic Resource
    Electronic Resource
    A laboratory investigation of the effect of alcohol upon attempts to reach agreement (1968)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 259 (1968), S. 180-180 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00537771
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  • 8
    Electronic Resource
    Electronic Resource
    Development of a direct weighting procedure for quality of life domains (1997)
    Springer
    Quality of life research 6 (1997), S. 301-309 
    Details
    ISSN: 1573-2649
    Keywords: Key words: Quality of life ; measurement ; decision making ; individual preferences.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Schedule for the Evaluation of Individual Quality of Life allows individuals to nominate the domains they consider most important to their quality of life and to use their own value system when describing the functional status and relative importance of those domains. The weights for domain importance are derived through a procedure called judgement analysis. As judgement analysis is impractical for individuals with cognitive impairment and in many clinical situations, a shorter, direct weighting procedure has been developed. To test the new procedure, 40 healthy individuals completed both direct and judgement analysis weightings, at t1 and 7-10 days later (t2). After a further 7-10 days (t3), they were asked to identify the weight profiles they had previously produced using each method. The weights produced by the two methods differed on average by 7.8 points at t1 and 7.2 points at t2. The direct weights changed on average by 4.5 points from t1 to t2, while the judgement analysis weights changed by 8.4 points. At t3, 55% of individuals were able to identify the direct weights they had previously produced. The new procedure demonstrates stability and validity but is not interchangeable with judgement analysis. The most appropriate ways of using and interpreting both procedures are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018423124390
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  • 9
    Electronic Resource
    Electronic Resource
    Individual quality of life in the healthy elderly (1994)
    Springer
    Quality of life research 3 (1994), S. 235-244 
    Details
    ISSN: 1573-2649
    Keywords: Elderly ; quality of life ; health status
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Quality of life research with the elderly has usually focused on the impact of decline in function, and used a pre-determined model of quality of life in old age. The Schedule for the Evaluation of Individual Quality of Life (SEIQoL) allows individuals to nominate, weigh and assess those domains of greatest relevance to their quality of life. The SEIQoL was administered to 56 healthy elderly community residents at baseline and 12 months later. Quality of life levels were significantly higher at baseline (t=−2.04; p=0.04) than that of a previously studied sample of healthy adults below 65 years of age, and did not change significantly over the study period. The domains nominated by both samples as relevant to their quality of life differed notably. Health status was not correlated with the perceived importance of health at baseline, and showed only a low correlation (r=0.27) at 12 months. The weight placed on health did not increase over the study period despite a significant decline in health status. The value of allowing the individual to define personal quality of life values in a research context is explored.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00434897
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