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Quantitative glomerular morphology of the normal and diabetic baboon kidney (1986)

Stout, L. C. ; Folse, D. S. ; Meier, J. ; [et al.]

Springer

Diabetologia 29 (1986), S. 734-740

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ISSN: 1432-0428

Keywords: Basement membrane ; mesangium ; diabetes ; baboons ; pancreatectomy ; quantitative glomerular morphometry

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary This is a study of quantitative glomerular morphology in 14 normal and 6l ong-term diabetic female baboons between 3 and 25 years of age. In the normal female baboon, peripheral glomerular capillary basement membrane thickness increased until around 10 years of age, reached a plateau between 10 and 20 years of age, and possibly decreased at 25 years of age. Mean values for young (3 to 7 years of age) and older (10 to 25 years of age) controls were 266 nm and 329 nm respectively. Fractional volumes of mesangial matrix (8.9%) and mesangial cells (6.8%) were not affected by age. Glomerular basement membrane thickness and the volume of mesangial matrix increased progressively in female baboons with poorly controlled pancreatectomy-induced diabetes, while the volume of mesangial cells remained unchanged. After 106 to 145 months of diabetes, glomerular basement membrane thickness and the volume of mesangial matrix were 558 nm and 18.7% respectively. These values were significantly greater than those of the age-matched controls (p = 〈 0.05). By light and electron microscopy, the normal baboon glomerular morphology, morphometric measurements and changes with age were similar to those in man. The renal changes in diabetic baboons were also similar in morphology and rate of development to those of mild to moderate diffuse diabetic glomerulosclerosis in humans, indicating that the baboon is an ideal model for the long-term study of diabetic glomerulosclerosis. The presence of considerable interanimal variability in the degree of glomerulosclerosis attained after prolonged diabetes suggested that glomerulosclerosis progressed at different rates in these models. The reason for this was not apparent.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00870284

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A theoretical study of the hyperpolarisabilities of nickel dithiolene molecules (1992)

Craig, B. I. ; Williams, G. R. J.

New York, NY [u.a.] : Wiley-Blackwell

Advanced Materials for Optics and Electronics 1 (1992), S. 221-228

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ISSN: 1057-9257

Keywords: Hyperpolarisabilities ; Nickel Dithiolene ; Non-linear optical properties ; CNDO method ; Finite field method ; Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Electrical Engineering, Measurement and Control Technology , Physics

Notes: The hyperpolarisabilities γ of nickel dithiolene complexes have been calculated by the finite field method in combination with the CNDO/S molecular orbital method. This computational technique, which has been developed for calculating the polarisation of large organic molecules by a perturbing electric field, is discussed. The changes in γ that occur as a result of different selections of substituent groups in the dithiolene ligand are described. The results are compared with recent experiments investigating these types of molecules. Large values for γ are found to arise from the interaction of the nickel 3d electrons with the conjugated π-electrons of the metal-ligand complex.

Additional Material: 2 Ill.