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  • Hair bulb papilla cells  (2)
  • Histology  (2)
  • Root sheath fibroblasts  (2)
  • Beeinflussung durch Serumcortisol  (1)
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 2 (1998), S. 14-19 
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Rekurrente Glossitis ; Makroglossie ; Diagnosekriterien ; Histologie ; Therapie ; Key words Recurrent glossitis ; Macroglossia ; Diagnostic features ; Histology ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: So-called “glossitis granulomatosa”, described in 1952 by H. Schuermann as a peculiar manifestation of Melkersson-Rosenthal syndrome (MRS), is little known in oral medicine due to the paucity of cases published so far. During the past 25 years the author has observed eight definite cases of glossitis granulomatosa and confirmed its close connections with MRS. The recurrent inflammation tends to change into persisting macroglossia with considerable functional and sensory oral disturbances. The clinical diagnosis, histologically supported by biopsy, can definitely be established, yet the outcome of the mostly chronic macroglossitis (with danger of later tongue carcinoma) may be very doubtful. Knowledge of Schuermann’s glossitis, a member of the group of etiologically unclarified lingual inflammations, is important for physicians involved in oral medicine because of its therapeutic and prognostic implications.
    Notes: Die 1952 von H. Schuermann als Sonderform des Melkersson-Rosenthal-Syndroms (MRS) beschriebene „Glossitis granulomatosa“ ist in der oralmedizinischen Literatur wenig bekannt bzw. kaum publiziert worden. Der Autor hat seit den 70er Jahren 8 einschlägige Patienten untersucht und pathogenetische Zusammenhänge mit dem MRS bestätigen können. Die zunächst rezidivierende, dann persistierende Entzündung führt zu ausgeprägter Makroglossie mit erheblichen funktionellen und sensorischen Beschwerden. Die höckerig-indurative Makroglossitis ist klinisch und histologisch meist klar erkennbar, die Prognose bei Chronizität aber dubiös (fakulative bis obligate Präkanzerose). Die Erkrankung gehört in den Formenkreis der ätiologisch ungeklärten granulomatösen Glossitiden und hat wegen ihrer therapeutischen und prognostischen Konsequenzen für die Mund-Kiefer- und Gesichtschirurgie praktische Bedeutung.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 244 (1972), S. 224-230 
    ISSN: 1432-069X
    Keywords: Malignant melanoma ; Histology ; Prognosis: vascularisation, inflammatory infiltrate ; Compartments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 280 (1988), S. 185-186 
    ISSN: 1432-069X
    Keywords: Human hair bulb papilla cells ; Root sheath fibroblasts ; Dermal fibroblasts ; Chemoattractants ; Chemotactic response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 271 (1981), S. 41-47 
    ISSN: 1432-069X
    Keywords: DNA synthesis activity of keratinocytes ; Diurnal rhythm of 3H-labeling index ; Influence of serum cortisol ; DNA-Syntheseaktivität der Keratinocyten ; Tagesrhythmik des 3H-Index ; Beeinflussung durch Serumcortisol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 12 gesunden männlichen Erwachsenen (Alter zwischen 20 und 27 Jahre) wurden zwei Langzeistudien über 48 und 66 h unter standardisierten äußeren Versuchsbedingungen durchgeführt, um Einblick in den tagesperiodischen Verlauf der Proliferationsaktivität der epidermalen Keratinocyten in Abhängigkeit vom Serumcortisolspiegel zu erhalten. Hierzu wurden in Stanzbiopsien der Haut der 3H-Thymidin-Markierungsindex in vitro mittels Autoradiographie und die Cortisolkonzentration im Venenblut mittels Radioimmunoassay alle 6 h bestimmt. Während der Cortisolspiegel typische circadiane Schwankungen während der gesamten Versuchszeit aufwies, ließen sich circadiane Schwankungen des epidermalen Markierungsindex erst ab 12 h nach Versuchsbeginn nachweisen. Als Ursache dieser zeitlichen Verzögerung wird eine initiale versuchsabhängige “Desynchronisation” im Zellcyclus der Keratinocyten diskutiert. Circadiane Maxima und Minima des Cortisolspiegels und der Proliferationsaktivität der Keratinocyten waren zueinander negative korreliert, wobei — unter den gewählten Zeitabständen des Versuchs — der Beginn des abendlichen Anstiegs der Proliferationsaktivität dem mitternächtlichen Tiefpunkt der Cortisolsekretion jeweils um 6 h vorausging. Die vor allem in den 66 h-Experimenten erhobenen proliferationskinetischen und hormonanalytischen Daten sprechen also nicht nur für eine — im Vergleich zu Versuchstieren schwächer ausgeprägte — tagesrhythmische Periodizität der epidermaen Proliferation, sondern auch für deren (wahrscheinlich indirekte) Regulation durch den endogenen Cortisolspiegel im Blut.
    Notes: Summary Performing two longitudinal studies over 48 and 66 h, respectively, in 12 healthy male adult volunteers the epidermal LI were measured by in vitro 3H-thymidine labeling technique every 6 h and serum cortisol levels simultaneously by RIA examination. While serum cortisol showed a circadian rhythm over the whole test period, a circadian rhythmic pattern of epidermal LI yet became evident 12 h after the onset of experiments. This initial time lag in appearance of LI periodicity may be due to some temporal desynchronization in the cell cycle of keratinocytes. Circadian peaks and minima of both cortisol and LI were found to be inversely correlated, with a time-shifting of 6 h according to the experimental conditions. The present results reveal strong evidence that circadian fluctuation of endogenous cortisol secretion does influence the regulation of epidermal DNA-synthesis in man.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-069X
    Keywords: Hair bulb papilla cells ; Hair root sheath fibroblasts ; Proliferation in vitro ; DNA flow cytometry ; Effect of different pharmacological agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Comparative studies on growth kinetics of cultivated human hair bulb papilla cells (PCs) and hair root sheath fibroblasts (RSFs) yielded evidence of some pecularities of PCs in both proliferative behavior and morphological growth pattern. As the dermal papilla, essentially supporting the nutrition of matrix epithelium, can be considered a target tissue for agents influencing maintenance of hair growth, we studied the effects of epidermal growth factor (EGF), fibroblasts growth factor (FGF), minoxidil (Mino), and hydrocortisone (HC) on the proliferation of PCs and RSFs, both gained from dissected hair follicles of scalp biopsy specimens of two male adults and separately cultured in vitro. EGF and FGF proved to increase proliferation of both PCs and RSFs most, yet at a different intensity for each cell group. HC slowed proliferation, and Mino failed to influence growth of PCs and RSFs.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-069X
    Keywords: Hair bulb papilla cells ; Root sheath fibroblasts ; Cell culture ; Growth pattern ; DNA flow cytometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Dermal papillae isolated from anagen hair bulbs obtained from biopsy specimens from five subjects with normal hair pattern, and fibroblasts derived from the mesenchymal root sheaths (RSF) of the same hair follicles were separately grown in culture and the cellcycle distribution pattern on different days was analysed by applying DNA flow cytometry (FCM). Papilla cells (PC) exhibited distinctive morphological features by forming cell aggregates differing from RSF with respect to cell shape and growth pattern. They also proliferated remarkably more slowly than RSF. DNA-FCM analysis showed that both PC and RSF demonstrated synchronous fluctuations in the percentage of cells in G1/0, S and G2+M phases during the period of subculture.
    Type of Medium: Electronic Resource
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