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  • 1
    Electronic Resource
    Electronic Resource
    Flow cytometric measurement of ploidy and proliferative activity of carcinomas of the oropharyngeal mucosa (1982)
    Springer
    Archives of dermatological research 273 (1982), S. 121-128 
    Details
    ISSN: 1432-069X
    Keywords: Flow-cytometry ; Oropharyngeal mucosa carcinomas ; Aneuploidy ; Proliferative activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The most important indicator of ploidy and cell cycle stage in ortho-and pathologous tissues is the nuclear DNA content. To study this parameter of malignancy in squamous carcinomas of the oral, pharyngeal, or laryngeal mucosa we analyzed DNA histograms by aid of flow cytophotometry after using pepsin digestion of tumor specimens for cell dispersal and fluorochromation with combined ethidium bromide and mithramycin. In 30 of 36 tumor tissue specimens aneupoid states of nuclear DNA content (83%) were recognized, in some cases only by comparing tumor cells with admixed diploid human reference cells. All but two tumors (with hypodiploid DNA pattern) exhibited hyperdiploid stem line abnormalities, one specimen even exhibited them with triclonal DNA distribution pattern. The degree of ploidy (DNA index), defined as the ratio of peak modal channel number for the G1/0 proportion of tumor cells to that of normal cells, ranged from 0.59 to 3.24 (mean 1.58). Cell cycle analysis of untreated squamous carcinomas, calculated by the relative DNA distribution pattern in histograms, also offered a considerable variation in proliferative activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00509036
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  • 2
    Electronic Resource
    Electronic Resource
    Inhibition of platelet aggregation by a new stable prostacyclin introduced in therapy of patients with progressive scleroderma (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 323-325 
    Details
    ISSN: 1432-069X
    Keywords: Platelet aggregation ; Raynaud's phenomenon ; Progressive systemic sclerosis ; Iloprost (ZK 36374) ; Intermittent infusion therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00509089
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  • 3
    Electronic Resource
    Electronic Resource
    DNA flow cytometry: A new technique for rapid analysis of cell-cycle kinetics in human anagen hairs (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 337-339 
    Details
    ISSN: 1432-069X
    Keywords: Flow cytometry (FCM) ; Cell-cycle kinetics ; Human anagen hairs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00509095
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro (1987)
    Springer
    Archives of dermatological research 279 (1987), S. 247-250 
    Details
    ISSN: 1432-069X
    Keywords: Hair bulb papilla cells ; Hair root sheath fibroblasts ; Proliferation in vitro ; DNA flow cytometry ; Effect of different pharmacological agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Comparative studies on growth kinetics of cultivated human hair bulb papilla cells (PCs) and hair root sheath fibroblasts (RSFs) yielded evidence of some pecularities of PCs in both proliferative behavior and morphological growth pattern. As the dermal papilla, essentially supporting the nutrition of matrix epithelium, can be considered a target tissue for agents influencing maintenance of hair growth, we studied the effects of epidermal growth factor (EGF), fibroblasts growth factor (FGF), minoxidil (Mino), and hydrocortisone (HC) on the proliferation of PCs and RSFs, both gained from dissected hair follicles of scalp biopsy specimens of two male adults and separately cultured in vitro. EGF and FGF proved to increase proliferation of both PCs and RSFs most, yet at a different intensity for each cell group. HC slowed proliferation, and Mino failed to influence growth of PCs and RSFs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417323
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  • 5
    Electronic Resource
    Electronic Resource
    Plasma levels of cyclic nucleotides are elevated in atopic eczema (1987)
    Springer
    Archives of dermatological research 279 (1987), S. S59 
    Details
    ISSN: 1432-069X
    Keywords: Atopic eczema ; cAMP ; cGMP ; Circadian plasma levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) taken at distinct times of the day were measured in 45 inpatients with generalized atopic eczema (AE). The results were compared with 34 healthy controls. Female patients not taking oral contraceptives (OC) and male patients revealed significantly higher median levels of cAMP in comparison with the controls (p〈0.002 for males;p〈0.001 for females). No significant cAMP differences were found between patients of either sex adn female controls taking OC. The median cGMP plasma levels did not differ between patients and controls. Both cyclic nucleotides are discussed under the aspectof cAMP as a second messenger of various hormones, reflecting and integrating different responses of the body to AE as a distressing systemic skin disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585922
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  • 6
    Electronic Resource
    Electronic Resource
    Collagen-type synthesis in human-hair papilla cells in culture (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 140-144 
    Details
    ISSN: 1432-069X
    Keywords: Hair papilla cells ; Cell culture ; Collagen synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hair-papilla derived cells were grown in monolayer culture and revealed the typical morphology and growth pattern which was similar but not identical to control fibroblasts. Hair-papilla cells were found to produce considerable amounts of collagen type I and type III and fibronectin. Type IV collagen production could not be detected. The ratio of collagen type III and type I clearly differed from the pattern observed in normal fibroblasts, being much higher in hair-papilla cells, where type III accounted for more than 20% of total collagen synthesis. These data show that hair-papilla derived cells have biosynthetic capacities similar to those of human skin fibroblasts as well as characteristic differences, indicating that they represent a specialized fibroblast subpopulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00456843
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  • 7
    Electronic Resource
    Electronic Resource
    Chemotactic response of human hair bulb papilla cells to chemoattractants in vitro (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 185-186 
    Details
    ISSN: 1432-069X
    Keywords: Human hair bulb papilla cells ; Root sheath fibroblasts ; Dermal fibroblasts ; Chemoattractants ; Chemotactic response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00456854
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  • 8
    Electronic Resource
    Electronic Resource
    Impairment of microphage functions in oral precancerous lesions and carcinomas (1981)
    Springer
    Archives of dermatological research 270 (1981), S. 197-199 
    Details
    ISSN: 1432-069X
    Keywords: Oral cancer and precancer ; Microphage function ; Killing test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00408235
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  • 9
    Electronic Resource
    Electronic Resource
    Effects of plucking on the anatomy of the anagen hair bulb (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 188-192 
    Details
    ISSN: 1432-069X
    Keywords: Mechanical plucking ; Trichogram ; Anagen hair bulb ; Breaking pattern
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of mechanical plucking on the anatomy of human anagen hair bulbs were studied histologically in biopsy specimens taken from scalp areas of ten volunteers immediately after plucking. Anagen hair bulbs were shown to tear off not arbitrarily but in reproducible patterns which include, apart from the “typical” break conically surrounding the dermal papilla, three additional break forms:(1) rupture of the hair around the upper third of the papilla resulting in so-called dysplastic anagen hairs of the trichogram, (2) rupture of the hair well above the dermal papilla resulting in “brocken” anagen hairs, (3) total removal of the proximal follicle epithelium with removal of the dermal papilla resulting in so-called papilla hairs of the trichogram. Plucking also gives rise to alterations of the mesenchymal sheath of the hair follicle mainly leading to hemorrhages and a distinct edema entailing an increase in the volume of both the dermal papilla and the underlying “papilla cushion” of Pinkus. The different break types can be due to inappropriate plucking techniques or may depend on different subphases of the anagen stage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00456391
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  • 10
    Electronic Resource
    Electronic Resource
    The irritant effect of different metalworking fluids (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 31 (1994), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The irritant effect of different water-based cutting fluids (CFs) on the skin was investigated in healthy subjects (n= 10) using 2 non-invasive bioengineering methods. Transepidermal water loss (TEWL) was measured by an evaporimeter EP1 (Servo Med), skin blood flow (SBF) was recorded with a laser Doppler flowmeter (MBF 3D, Moor Instruments England). Additionally all test sites were evaluated by visual scoring before measurement. 3 cutting fluids A, B and C from different manufacturers were tested at use concentrations of 4% or 5%. Single 24-h patch tests and repeated patch tests were performed on the volar side of the right forearm. Measurements were carried out before and after exposure to assess basal values and the skin response to CF. Tests with CFs A and C resulted in significant increase in TEWL after 24 h and after cumulative treatment, compared with controls (p 〈 0.01). The TEWL values for CF B did not differ from the water probe. An increase in SBF was found only for CFs A and C after cumulative patch testing (p 〈 0.01). In spite of their similar alkalinity, the 3 CFs showed different irritant skin reactions, due to their chemical components. This was verified particularly by measurement of TEWL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1994.tb01992.x
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