ISSN:
1432-2277
Keywords:
Key words Kidney preservation
;
Viability testing
;
Ischemia
;
Non-heart-beating donor
;
Heart-beating donor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract For the past decades, severe hypothermia has represented the foundation of organ preservation in clinical transplantation. Beneficial as hypothermia has proven to be in preserving grafts from heart-beating donors, hypothermia does not seem to provide the window necessary for the prospective evaluation of organ function. With the increasing use of non-heart-beating donors, it is logical to propose that if organs are to be evaluated prospectively, it will be necessary to preserve them at warmer temperatures. Since both glomerular and tubular functions are inhibited at temperatures below 18 °C, such a goal will necessitate organ preservation at a temperature above 20 °C. The principle of preservation at warmer temperatures is not new, but with future developments and approaches, successful realization appears within reach. In this overview, a brief history of previous attempts at warm preservation, in the context of the current status of kidney preservation, is presented. Future developments and approaches, with the potential for prospective testing of the function and enhanced resistance to ischemic damage, will be discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001470050191
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