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  • Electrophoretic mobility  (2)
  • Biochemical parameters  (1)
  • Biologische Funktion  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Biological and clinical relevance of human macrophage migration inhibitory factor (MIF) (1979)
    Springer
    Annals of hematology 38 (1979), S. 93-101 
    Details
    ISSN: 1432-0584
    Keywords: Lymphokine ; Makrophagen-Migrationshemmfaktor (MIF) ; Biochemische Parameter ; Biologische Funktion ; Klinische Bedeutung ; Lymphokines ; Macrophage migration inhibitory factor (MIF) ; Biochemical parameters ; Biological function ; Clinical relevance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The first isolation and characterization of a lymphokine, the human MIF (MSF), and the availability of a specific MIF (MSF)-antibody provide an opportunity to establish a new parameter for detection of cellular immune mechanisms in various clinical situations. The precise estimation of quantitative amounts of MIF by sensitive immunochemical techniques could gain new insights into the pathogenesis of a number of clinical disorders. In addition, the exact detection of quantitative amounts of MIF in body fluids could have prognostic value.
    Notes: Zusammenfassung Die erste Isolierung und Charakterisierung eines Lymphokins, des menschlichen MIF (MSF), und die Gewinnung eines spezifischen MIF (MSF)-Antikörpers eröffnen die Möglichkeit, neue Parameter für die Bestimmung zellulärer Immunmechanismen bei verschiedenen klinischen Situationen zu gewinnen. Die genaue quantitative Bestimmung mit empfindlichen immunochemischen Techniken könnte einen Einblick in die Pathogenese verschiedener klinischer Erkrankungen ermöglichen. Zusätzlich könnte der quantitativen Bestimmung von MIF in Körperflüssigkeiten eine prognostische Bedeutung zukommen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01007950
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Postnatale Entwicklung von Rattenthrombozyten: Die Volumenverteilung und elektrophoretische Beweglichkeit von Rattenthrombozyten während des ersten Lebensmonats (1980)
    Springer
    Annals of hematology 40 (1980), S. 421-428 
    Details
    ISSN: 1432-0584
    Keywords: Rat ; Thrombocytes ; Cell volume ; Electrophoretic mobility ; Haematopoiesis ; Ratten ; Thrombozyten ; Zellvolumen ; elektrophoretische ; Beweglichkeit ; Hämatopoese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Volumenverteilung von Rattenthrombozyten zeigt zwischen dem 5. und dem 8. Tag nach Geburt eine deutliche Zunahme im Modalvolumen. Bei rechnerischer Analyse der Kurven konnten keine deutlichen Anhaltspunkte für zwei diskrete Thrombozytenpopulationen gefunden werden. Da sich jedoch der Anstieg des Modalvolumens mit dem Beginn der Produktion einer neuen Erythrozytenpopulation deckt, und außerdem die Thrombozytenkonzentration im Blut in dieser Zeit deutlich ansteigt, können diese Veränderungen Ausdruck der Produktion einer zweiten Thrombozytenpopulation sein. Die mittlere elektrophoretische Beweglichkeit der Rattenthrombozyten fällt in den ersten drei Wochen nach Geburt nur geringfügig ab, während die der Erythrozyten im gleichen Zeitraum signifikant anstiegt.
    Notes: Summary The volume distribution curves of rat thrombocytes show a significant rise of the modal volume between days 5 and 8 after birth. No clear evidence for two distinct thrombocyte populations was obtained by computer analysis of the volume distribution curves. However, the increase of the modal volume of the platelets correlates with the production of a new erythrocyte population. In addition, the platelet concentration in the blood increases significantly during this time. These changes could indicate the production of a second thrombocyte population. The mean electrophoretic mobility of rat thrombocytes decreases only slightly during the first 3 weeks after birth, while it increases for erythrocytes significantly during the same period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01029684
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Flow-cytometric measurements of the transmembrane potential, the surface charge density and the phagocytic activity of guinea pig macrophages after incubation with lymphokines (1981)
    Springer
    Annals of hematology 42 (1981), S. 379-382 
    Details
    ISSN: 1432-0584
    Keywords: Macrophage ; Lymphokine ; Transmembrane potential ; Phagocytosis ; Electrophoretic mobility ; Flow cytometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of lymphokines on guinea pig peritoneal macrophages were measured via flow cytometry utilizing the three-parameter FLUVO-METRICELL flow cytometer. On the basis of cell volume three distinct macrophage populations could be distinguished. Three to 5 min after starting the incubation with lymphokines a hyperpolarization of all three macrophage populations took place which was followed by depolarization. After 60 min the transmembrane potential reached again its control values. The negative charge density of the cell membrane decreased shortly after beginning of the incubation to 70-80% of the initial value and then remained unchanged for the following 120 min. The phagocytic activity of the macrophages was diminished during the depolarisation phase but increased over control values after restoration of the transmembrane potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00996900
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    Paper (German National Licenses)
    Fulltext
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