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  • 1
    ISSN: 1432-1920
    Keywords: Key words Glioblastoma ; Computed tomography ; Magnetic resonance imaging ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Few studies have attempted to correlate neuroimaging with outcome in patients with glioblastoma. Our aim was to evaluate the relationship between neuroradiological findings and survival in these patients. We studied 18 consecutive patients with glioblastoma who had undergone surgery and radiotherapy. We assessed the following features, using preoperative CT and/or MRI: tumour size, extent of necrotic area within the mass, extent of perifocal oedema and contrast enhancement. The mean survival was 14.2 ± 5 months (range 6–22). The extent of radiological evidence of necrosis within the mass correlated significantly with survival time, whereas tumour size, perifocal oedema and contrast enhancement did not.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1920
    Keywords: Glioblastoma ; Computed tomography ; Magnetic resonance imaging ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Few studies have attempted to correlate neuroimaging with outcome in patients with glioblastoma. Our aim was to evaluate the relationship between neuroradiological findings and survival in these patients. We studied 18 consecutive patients with glioblastoma who had undergone surgery and radiotherapy. We assessed the following features, using preoperative CT and/or MRI: tumour size, extent of necrotic area within the mass, extent of perifocal oedema and contrast enhancement. The mean survival was 14.2 ± 5 months (range 6–22). The extent of radiological evidence of necrosis within the mass correlated significantly with survival time, whereas tumour size, perifocal oedema and contrast enhancement did not.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 17 (1996), S. 291-294 
    ISSN: 1590-3478
    Keywords: Cerebral vasospasm ; Brain tumors ; Transcranial Doppler
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Il vasospasmo cerebrale è una condizione clinico-angiografica che si osserva frequentemente dopo una emorragia subaracnoidea da rottura di un aneurisma intracranico. L'osservazione del vasospasmo dopo l'exeresi di un tumore cerebrale è riportato in letteratura in 20 casi. Segnaliamo 5 nuovi casi di vasospasmo verificatisi dopo l'asportazione di un tumore cerebrale, trattandone gli aspetti patogenetici. A nostro avviso è importante considerare il vasospasmo come probabile causa eziologica di deterioramento clinico nei pazienti sottoposti ad intervento chirurgico di rimozione di un tumore cerebrale. Per tale motivo, nei pazienti operati per tumore cerebrale che presentino un deterioramento dello stato neurologico, è consigliabile l'esecuzione di un doppler transcranico, al fine di rilevare l'eventuale presenza di vasospasmo cerebrale ed instaurare prontamente la terapia adeguata.
    Notes: Abstract Cerebral vasospasm is a clinical/angiographical condition frequently observed after a subarachnoid hemorrhage due to the rupture of an intracranial aneurysm. Twenty cases of vasospasm observed after the removal of cerebral tumors have been reported in the literature; we here report on a further five. The time of onset of symptomatic vasospasm was 3–7 days after surgery; three of the patients died of an ischemic event induced by the vasospasm and two survive. Although no angiographic confirmation was obtained in our cases, serial transcranial Doppler (TCD) flow velocities were always high. It is suggested that the TCD-revealed accumulation of blood in the basal cisterns observed in all cases may have been responsible for this unusual condition, and it is therefore important to consider vasospasm as a probable etiological cause of clinical deterioration in patients undergoing the surgical removal of a cerebral tumor. For this reason, whenever any neurological deterioration occurs in such patients, it is advisable to perform TCD in order to verify the presence of any vasospasm and promptly commence suitable treatment.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 2 (1981), S. 363-367 
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: SCF Hartree-Fock calculations are used to predict properties of the guanidinium fragment present in tetrodotoxin and saxitoxin, toxins known to block the sodium channels of the nerve cell membrane. The results, in terms of net atomic charges and geometries, are compared to similar calculation results obtained for the Na+-H2O complex.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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