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Digitale Medien

Synthesis and structural characterization of the hydrido carbido ruthenium cluster [PPh4][Ru6C(CO)16H] (1992)

Chihara, Teiji ; Yamazaki, Hiroshi

Springer

Journal of cluster science 3 (1992), S. 489-497

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ISSN: 1572-8862

Schlagwort(e): Hydrido cluster ; ruthenium cluster ; interstitial carbido ligand ; crystallographic structure ; monoanionic cluster

Quelle: Springer Online Journal Archives 1860-2000

Thema: Maschinenbau , Physik

Notizen: Abstract According to the protonation of [PPh4]2[Ru6C(CO)16] (1b) withp-toluene-sulfonic acid, a hydrido ruthenium cluster [PPh4][Ru6C(CO)16H] (3b) was obtained in 53% yield, which readily decomposed in protic solvents even at −20°C to yield1b, Ru6C(CO)16H2, and Ru5C(CO)15. Cluster3b was characterized by single-crystal X-ray analysis. The six metal atoms are arranged in the form of an octahedron with the carbido ligand located in the center. There are 13 terminal carbonyl, three bridging carbonyl, and a bridging hydrido ligands.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00702754

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Digitale Medien

CYP2A6 genetic polymorphisms and liver microsomal coumarin and nicotine oxidation activities in Japanese and Caucasians (2000)

Inoue, Kiyoshi ; Yamazaki, Hiroshi ; Shimada, Tsutomu

Springer

Archives of toxicology 73 (2000), S. 532-539

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ISSN: 1432-0738

Schlagwort(e): Key wordsCYP2A6 polymorphism ; Coumarin ; Nicotine ; Japanese ; Caucasian

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Genotypes of CYP2A6, namely CYP2A6 * 1 (wild-type), CYP2A6 * 2, and CYP2A6 * 3, were examined in liver DNA of 39 Japanese and 43 Caucasians using two-step polymerase chain reaction (PCR) methods. We first amplified a DNA fragment (1725 bp) located between near middle of exon 1 and end of exon 4 of the CYP2A6 gene and further amplified using a forward primer 't' or 'mut' (middle of exon 3) and a reverse primer 'E3R' (middle of intron 3) for the detection of CYP2A6 * 2-genetic polymorphism. The 1725 bp fragment was also used for the amplification between exon 3 and near middle of intron 3 of the CYP2A6 gene and the fragment thus obtained digested with XcmI or DdeI to detect and confirm the CYP2A6 * 2- and CYP2A6 * 3-types, respectively. Only one DNA sample from a Japanese origin (J18) was not amplified by CYP2A6-specific primers; liver microsomes from this individual had very low activity of coumarin 7-hydroxylation and were devoid of protein(s) immunoreactive to anti-CYP2A6 antibody. Thus, this individual was suggested to be due to the gene deletion in CYP2A6. By analyzing the remaining 38 Japanese and 43 Caucasians, we found that there were no cases of CYP2A6 * 3-type polymorphism in the samples examined in this study, and no cases of CYP2A6 * 2-type polymorphism in the Japanese samples. Of Caucasians studied two individuals were classified into heterozygous CYP2A6 * 1/ * 2-type. Liver microsomal coumarin 7-hydroxylation activities in these two Caucasians were found to be lower than those of the other 41 Caucasians. Kinetic analysis showed that two CYP2A6 * 1/ * 2 individuals had a very low ratio of V max to K m for nicotine C-oxidation as well as coumarin 7-hydroxylation in liver microsomes, compared with those of homozygous CYP2A6 * 1-type. These results suggest that among 39 Japanese and 43 Caucasians examined one Japanese is classified to be CYP2A6 gene deletion and two Caucasians are heterozygous CYP2A6 * 1/ * 2-genotype. Thus the race-related differences in the occurrence of CYP2A6 genetic polymorphisms were supported.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s002040050005

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Digitale Medien

A Low-Loss Built-In Current Sensor (1999)

Miura, Yukiya ; Yamazaki, Hiroshi

Springer

Journal of electronic testing 14 (1999), S. 39-48

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ISSN: 1573-0727

Schlagwort(e): Built-in current sensor ; IDDQ testing ; low-voltage LSIs ; multiple power supplies

Quelle: Springer Online Journal Archives 1860-2000

Thema: Elektrotechnik, Elektronik, Nachrichtentechnik

Notizen: Abstract This paper presents a novel built-in current sensor that uses two additional power supply voltages besides the system power supply voltage, and that is constructed by using a current mirror circuit to pick up an abnormal IDDQ. It is activated only by an abnormal quiescent power supply current and minimizes the voltage drop at the terminal of the circuit under test. Simulation results showed that it could detect 16-μA IDDQ against 0.03-V voltage drop at 3.3-V VDD and that it reduced performance degradation in the circuit under test. It is therefore suitable for testing low-voltage integrated circuits. Moreover, we verified the behavior of the sensor circuit implemented on the board by using discrete devices. Experimental results showed that the real circuit of the sensor functioned properly.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1023/A:1008393104650

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Digitale Medien

Fluorescencein situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1 (1994)

Inoue, Kiyoshi ; Inazawa, Johji ; Suzuki, Yasuhiko ; [weitere]

Springer

Journal of human genetics 39 (1994), S. 337-343

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ISSN: 1435-232X

Schlagwort(e): fluorescencein situ hybridization ; CYP2C subfamily ; chromosome 10 ; chromosomal localization ; polymerase chain reaction

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary Chromosomal localization of three human cytochrome P450 genes belonging to the CYP2C subfamily (CYP2C8, 2C9, and 2C10) was identified by fluorescencein situ hybridization (FISH). An original MP-8 clone was used as a DNA probe for the assignment of the CYP2C10 gene, while two cDNA probes, a 1.37 kb fragment of CYP2C8 and a 1.19 kb fragment (MP-20 and MP-4 clones, respectively) by polymerase chain reaction using a single human liver cDNA library. The results showed that three human CYP2C8, 2C9, and 2C10 cDNAs were located at the same subchromosomal region, 10q24.1.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01874052

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Digitale Medien

Production of ethyl acetate from dilute ethanol solutions by Candida utilis (1984)

Armstrong, David W. ; Martin, Stanley M. ; Yamazaki, Hiroshi

New York, NY [u.a.] : Wiley-Blackwell

Biotechnology and Bioengineering 26 (1984), S. 1038-1041

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ISSN: 0006-3592

Schlagwort(e): Chemistry ; Biochemistry and Biotechnology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: The conversion of ethanol to ethyl acetate has an advantage as a method of ethanol recovery since ethyl acetate is amenable to simple solvent extraction. The potential of Candida utilis in this conversion was studied. The kinetics of accumulation of ethanol and ethyl acetate in glucose-grown C. utilis showed that ester formation resulted from ethanol utilization under appropriate aeration and was inhibited by Fe3+ supplementation. Candida utilis converted ethanol to ethyl acetate optimally at pH 5.0-7.0. The five-hour rate of ester production increased as the ethanol concentration increased to 10 g/L, and rapidly declined to zero at concentrations exceeding 35 g/L. Thus, C. utilis has potential to recover dilute ethanol in the form of ethyl acetate.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bit.260260905

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