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  • Inorganic Chemistry  (2)
  • Biochemistry and Biotechnology  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The high-resolution crystal structure of porcine pepsinogen (1992)
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 13 (1992), S. 1-25 
    Details
    ISSN: 0887-3585
    Keywords: aspartic proteinase zymogen ; molecular replacement ; structure-function ; activation peptide ; acid activation ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The structure of porcine pepsinogen at pH 6.1 has been refined to an R-factor of 0.173 for data extending to 1.65 Å. The final model contains 180 solvent molecules and lacks density for residues 157-161. The structure of this aspartic proteinase zymogen possesses many of the characteristics of pepsin, the mature enzyme. The secondary structure of the zymogen consists predominantly of β-sheet, with an approximate 2-fold axis of symmetry. The activation peptide packs into the active site cleft, and the N-terminus (IP-9P) occupies the position of the mature N-terminus (1-9). Thus changes upon activation include excision of the activation peptide and proper relocation of the mature N-terminus. The activation peptide or residues of the displaced mature N-terminus make specific interactions with the substrate binding subsites. The active site of pepsinogen is intact; thus the lack of activity of pepsinogen is not due to a deformation of the active site. Nine ion pairs in pepsinogen may be important in the advent of activation and involve the activation peptide or regions of the mature N-terminus which are relocated in the mature enzyme. The activation peptide-pepsin junction, 44P-1, is characterized by high thermal parameters and weak density, indicating a flexible structure which would be accessible to cleavage. Pepsinogen is an appropriate model for the structures of other zymogens in the aspartic proteinase family. © 1992 Wiley-Liss, Inc.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prot.340130102
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  • 2
    Electronic Resource
    Electronic Resource
    Studien über das Indium (1910)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 66 (1910), S. 288-321 
    Details
    ISSN: 0863-1778
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Indium lässt sich durch Fällung des Hydroxyds mit Ammoniak und Erhitzen auf 850° im Filtertiegel mit großer Genauigkeit quantitativ bestimmen.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19100660119
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  • 3
    Electronic Resource
    Electronic Resource
    Adsorptionsuntersuchungen an Organokieselsäurepolymeren (1992)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 612 (1992), S. 137-142 
    Details
    ISSN: 0044-2313
    Keywords: Adsorption and swelling ; isothermes ; specific surfaces ; organosilicic acid ; double four-ring silicate units ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Adsorption Studies on Organosilic Acid PolymersWe present four organosilic acid polymers containing double-4-ring silicate units cross-linked at different degree by different organosilicon bridges. BET surfaces were determined and adsorption isotherms of n-hexane, benzene, nitrogen and water were measured. All polymers are hydrophobic, one of them behaves microporously, the other are unporous. With organic adsorptives, swelling and adsorption occur simultaneously. Possible relations of microporosity and structure are discussed.
    Notes: BET-Oberflächen und Isothermen von n-Hexan, Benzen, Wasser und Stickstoff wurden an vier Organokieselsäurepolymeren vermessen, die sich im Vernetzungsgrad der Doppelvierring-Kieselsäureeinheiten Si8O20 und in der Struktur der Brücken unterscheiden. Ein Polymere ist mikroporös, die anderen sind unporös. Alle Polymere verhalten sich hydrophob. Neben der Adsorption tritt Quellung bei der Einwirkung organischer Adsorptive auf. Die Zusammenhänge zwischen der Länge der Brücken und der Porosität werden diskutiert.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19926120123
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    Paper (German National Licenses)
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