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  • 1
    Electronic Resource
    Electronic Resource
    Neurotransmitters in the spinal cord dorsal horn in a model of painful neuropathy and in nerve crush (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 478-485 
    Details
    ISSN: 1432-0533
    Keywords: Key words Chronic constriction injury ; Crush ; Dorsal horn ; Hyperalgesia ; Neurotransmitters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We tested the hypothesis that neurochemical changes in the spinal cord dorsal horn associated with neuropathic pain states differ from those seen in association with non-painful neuropathies. Immunohistochemistry was performed on spinal cord sections from rats with a chronic constriction injury (CCI), which develop hyperalgesia, and from animals with a nerve crush injury, which do not develop hyperalgesia or other signs of a painful syndrome. Immunohistochemistry was quantified by computer-assisted densitometry. Calcitonin gene-related peptide (CGRP) immunoreactivity and substance P (SP) immunoreactivity were decreased from 1 to 4 weeks after injury in CCI and from 2 to 6 weeks in crush. Gamma-aminobutyric acid immunoreactivity was unchanged in both conditions at all time points. Met-enkephalin (Met-enk) immunoreactivity was increased in CCI and unchanged in crush. Although SP and CGRP are involved in pain transmission, we conclude that their decrease in immunoreactivity is not specific for the CCI model, but rather a more general event in nerve de- and regeneration. The increase in immunoreactivity for the opioid peptide Met-enk, however, was only seen in the late phase of CCI, and may be specific for conditions associated with neuropathic pain and its resolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294809
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Neurotransmitters in the spinal cord dorsal horn in a model of painful neuropathy and in nerve crush (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 478-485 
    Details
    ISSN: 1432-0533
    Keywords: Chronic constriction injury ; Crush ; Dorsal horn ; Hyperalgesia ; Neurotransmitters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We tested the hypothesis that neurochemical changes in the spinal cord dorsal horn associated with neuropathic pain states differ from those seen in association with non-painful neuropathies. Immunohistochemistry was performed on spinal cord sections from rats with a chronic constriction injury (CCI), which develop hyperalgesia, and from animals with a nerve crush injury, which do not develop hyperalgesia or other signs of a painful syndrome. Immunohistochemistry was quantified by computer-assisted densitometry. Calcitonin gene-related peptide (CGRP) immunoreactivity and substance P (SP) immunoreactivity were decreased from 1 to 4 weeks after injury in CCI and from 2 to 6 weeks in crush. Gammaaminobutyric acid immunoreactivity was unchanged in both conditions at all time points. Met-enkephalin (Metenk) immunoreactivity was increased in CCI and unchanged in crush. Although SP and CGRP are involved in pain transmission, we conclude that their decrease in immunoreactivity is not specific for the CCI model, but rather a more general event in nerve de- and regeneration. The increase in immunoreactivity for the opioid peptide Met-enk, however, was only seen in the late phase of CCI, and may be specific for conditions associated with neuropathic pain and its resolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294809
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Enzymology of the degradation of (di)chlorobenzenes by Xanthobacter flavus 14p1 (1997)
    Springer
    Archives of microbiology 167 (1997), S. 384-391 
    Details
    ISSN: 1432-072X
    Keywords: Key words Xanthobacter flavus ; Dichlorobenzene ; Biodegradation ; Modified ortho pathway ; Toxicity ; Chloromuconate cycloisomerase ; Dienelactone ; hydrolase ; Maleylacetate reductase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Xanthobacter flavus 14p1 used 1,4-dichlorobenzene as the sole source of carbon and energy but did not grow on other (chloro)aromatic compounds. 1,4-Dichlorobenzene was attacked by a chlorobenzene dioxygenase, and the intermediate chlorocatechol was metabolized by the modified ortho pathway. All enzymes necessary to convert 1,4-dichlorobenzene to 3-oxoadipate showed a low substrate specificity and also accepted the respective intermediates of chlorobenzene or 1,3-dichlorobenzene degradation. Of the three compounds chlorobenzene, 1,4-dichlorobenzene, and 1,3-dichlorobenzene, the latter was the most toxic for X. flavus 14p1. Furthermore, 1,3-dichlorobenzene did not induce chlorocatechol 1,2-dioxygenase activity of the organism. Chlorobenzene, however, induced chlorocatechol 1,2-dioxygenase, dienelactone hydrolase, and maleylacetate reductase activities. As demonstrated by chloride release, also chlorobenzene dioxygenase, chlorobenzene cis-dihydrodiol dehydrogenase, and chloromuconate cycloisomerase activities were present in chlorobenzene-induced cells, but chlorobenzene failed to support growth. Presumably a toxic compound was formed from one of the intermediates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002030050459
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Untersuchungen zum Netzwerkbildungsprozeß bei der Reaktion von Bisphenol A-Diglycidylether mit 4,4′-Diaminodiphenylmethan (1992)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 196 (1992), S. 195-206 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: The network formation process of bisphenol A-diglycidylether and 4,4′-diaminodiphenylmethane was investigated by measuring the torque, the conductivity and the soluble part of the crosslinking system. The activation energy for the curing process was estimated from gel time. The volume shrinkage during network formation was measured. The influence of N,N-dimethylbenzylamine as accelerator was discussed.
    Notes: Der Aufbau von Netwerken aus Bisphenol A-Diglycidylether und 4,4′-Diaminodiphenylmethan wurde durch Messung des Drehmomentes, der Leitfähigkeit und durch Bestimmung der löslichen Anteile des vernetzenden System untersucht. Aus den Gelzeiten wurden die Aktivierungsenergie für den Vernetzungsprozeß bestimmt. Außerdem wurde die während der Vernetzung aufretende Volumenschwindung gemessen. Der Einfluß von N, N-Dimethylbenzylamin als Beschleuniger auf den Vernetzungsprozeß wird diskutiert.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1992.051960116
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    Paper (German National Licenses)
    Fulltext
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