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  • 1
    Electronic Resource
    Electronic Resource
    Early but not delayed continuous arteriovenous hemofiltration improves cardiovascular function in sepsis in dogs (1999)
    Springer
    Intensive care medicine 25 (1999), S. 733-743 
    Details
    ISSN: 1432-1238
    Keywords: Key words Cardiac depression ; Myocardial depressant factor ; Dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Objective: Continuous arteriovenous hemofiltration (CAVH) has been advocated as treatment to remove inflammatory mediators and thereby to improve hemodynamic parameters in sepsis. However, the results obtained with CAVH have been inconsistent. In a canine model of bacteremic Pseudomonas aeruginosa pneumonia, we tested the hypothesis that the time course of the institution of CAVH may be important in obtaining a beneficial treatment effect. Methods: Two protocols were performed in phenobarbital-anesthetized dogs. In the early hemofiltration study (EHS), CAVH for 3 h was initiated 2 h post-pneumonia before mean arterial pressure (MAP) fell. In the late hemofiltration study (LHS), CAVH for 3 h was initiated at 5 h post-pneomonia when a decrease in MAP had already occurred. Hemodynamic measurements included cardiac output (CO), stroke volume (SV), and stroke work (SW). Myocardial depressant activity [filterable cardiodepressant substance (FCS)] found in plasma was assessed by bioassay at each measurement interval. Results: In EHS, after 5 h of sepsis, SW, CO, and SV in the hemofiltered pneumonia group were higher as compared with the nonhemofiltered pneumonia group. In contrast, in LHS, no differences in hemodynamic parameters were found between the two pneumonia groups. In both EHS and LHS, plasma FCS activity was decreased to similar extents by CAVH. Conclusion: These results suggest the time course of institution of CAVH may be important in obtaining a beneficial treatment effect in sepsis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050938
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Detection of radiation effects using recombinant bioluminescent Escherichia coli strains (2000)
    Springer
    Radiation and environmental biophysics 39 (2000), S. 41-45 
    Details
    ISSN: 1432-2099
    Keywords: Key words Ionizing radiation biosensor ; DNA damage ; Oxidative damage ; Protein damage ; Stress promoters ; Bioluminescent bacteria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract  Effects of ionizing radiation (0.1–500 Gy) on recombinant Escherichia coli cells containing the stress promoters recA, grpE, or katG, fused to luxCDABE, were characterized by monitoring transcriptional responses reflected by the bioluminescent output. The minimum dose of gamma-irradiation detected by E. coli DPD2794 (recA::luxCDABE) was about 1.5 Gy, while the maximum response was obtained at 200 Gy. The amount of emitted bioluminescence increased proportionally with the gamma-ray doses which were found to elicit a DNA damage response in a range of 1–50 Gy. In addition, the cell growth rate was severely, but transiently, retarded by about 50 Gy. Quantification of the gamma-ray dose may be possible using the recA promoter fusion, since linear enhancement of the bioluminescence emission with increasing gamma-ray dose was observed. Other irradiated strains (50 Gy) responsive to either oxidative stress (DPD2511, katG::luxCDABE) or protein-damaging stress (TV1061, grpE::luxCDABE) did not display an increased bioluminescent output, while DPD2794 irradiated by the same dose of gamma-rays gave a significant bioluminescent output. This indicates that the recA promoter is the one most suitable for developing a biosensor for ionizing radiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007683
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    Paper (German National Licenses)
    Fulltext
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