Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Degradation of methyl and ethyl mercury into inorganic mercury by various phagocytic cells (1992)
    Springer
    Archives of toxicology 66 (1992), S. 40-44 
    Details
    ISSN: 1432-0738
    Keywords: Methyl mercury ; Ethyl mercury ; Biotrans-formation ; Reactive oxygen ; Phagocytic cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In connection with the dealkylation of methyl mercury (MeHg) and ethyl Hg (EtHg) with reactive oxygen-producing systems, we examined the ability of phagocytic cells to degrade MeHg or EtHg into inorganic mercury in vitro by collecting them from blood or peritoneal cavity of several species of animal. EtHg was readily degraded by human polymorphonuclear leukocytes (PMN), rat PMN, guinea-pig PMN, rabbit PMN, guinea-pig macrophages (Mφ), human monocytes and guinea-pig eosinophils. In contrast, rat hepatocytes and the Mφ hybridoma clone 39 cells were weaker in their degrading ability. Degradation of MeHg by these cells was always much weaker than EtHg, under identical conditions; how-ever, by increasing the cell numbers, MeHg was appreciably degraded by human PMN, rat PMN and rabbit PMN. The reactive oxygen species mainly responsible for alkyl Hg degradation seemed to be hydroxyl radicals produced by Mφ, and hypochlorous acid produced by PMN, monocytes and eosinophils. It was also suggested that the degradation of alkyl Hg by these cells might be an intraphagosomal event.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02307268
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Degradation of methyl and ethyl mercury into inorganic mercury by other reactive oxygen species besides hydroxyl radical (1992)
    Springer
    Archives of toxicology 66 (1992), S. 34-39 
    Details
    ISSN: 1432-0738
    Keywords: Methyl mercury ; Ethyl mercury ; Biotrans-formation ; Reactive oxygen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Degradation of methyl mercury (MeHg) and ethyl Hg (EtHg) with reactive oxygens was studied in vitro by using peroxidase-hydrogen peroxide (H2O2)-halide and rose bengal-ultraviolet light A systems. For this purpose, the direct determination method for inorganic Hg was employed. Both systems could effectively degrade EtHg, and MeHg to some extent. Degradation of MeHg and EtHg with the myeloperoxidase (MPO)-H2O2-chloride system was inhibited by MPO inhibitors (cyanide and azide), catalase, hypochlorous acid (HOCl) scavengers (glycine, alanine, serine and taurine), 1,4-diazabicyclo[2,2,2]octane and 2,5-dimethylfuran, but not by hydroxyl radical scavengers (ethanol and mannitol). Iodide was more effective than chloride as the halide component. Lactoperoxidase (LPO) could substitute for MPO in the iodide, but not the chloride system. With MPO-H2O2-chloride, MPO-H2 O2-iodide and LPO-H2O2-iodide systems, we observed the increased degradation of EtHg in deuterium oxide (D2O) medium better than that in H2O medium. The D2O effect upon MeHg degradation was extremely weak. These results suggested that HOCl (or HOI) might be also capable of degrading MeHg and EtHg, besides the hydroxyl radical already reported by us. Singlet oxygen could degrade EtHg but not MeHg.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02307267
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...