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  • 1
    Electronic Resource
    Electronic Resource
    A computational system for process design of injection moulding: Combining a blackboard-based expert system and a case-based reasoning approach (1998)
    Springer
    The international journal of advanced manufacturing technology 14 (1998), S. 350-357 
    Details
    ISSN: 1433-3015
    Keywords: Blackboard architecture ; Case-based reasoning ; Expert system ; Process design of injection moulding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Process design of injection moulding involves the selection of the injection moulding machine, mould design, production scheduling, cost estimation, and determination of injection moulding parameters. An expert system approach has been used to derive the process solution for injection moulding over the past few years. However, this approach is found to be incapable of determining the injection moulding parameters owing to the fragile nature of the knowledge for setting the moulding parameters. In addition, the existing expert systems for process design lack proper architecture for organising heterogeneous knowledge sources. In this paper, the combination of a blackboard-based expert system and a case-based reasoning approach is introduced to eliminate the deficiency of the existing expert-system approach to process design, from which a computational system for the process design of injection moulding, named CSPD, has been developed. CSPD first derives the process solution including the selection of the injection moulding machine and the mould base, tooling cost, processing cost estimation, and production scheduling based on the blackboard-based expert-system approach. It is then followed by the determination of the injection moulding parameters based on the case-based reasoning approach and the previously derived partial solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01178914
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A computational system for process design of injection moulding: Combining blackboard-based expert system and case-based reasoning approach (1998)
    Springer
    The international journal of advanced manufacturing technology 14 (1998), S. 239-246 
    Details
    ISSN: 1433-3015
    Keywords: Blackboard architecture ; Case-based reasoning ; Expert system ; Process design of injection moulding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The process design of injection moulding involves the selection of the injection moulding machine, mould design, production scheduling, cost estimation, and determination of injection moulding parameters. Expert system approaches have been attempted to derive the process solution for injection moulding in the past few years. However, this approach has been found to be incapable of determining the injection moulding parameters owing to the difficulty in setting the moulding parameters. In addition, the existing expert systems for process design lack the proper architecture for organising a heterogeneous knowledge source. In this paper, the combination of a blackboard-based expert system and case-based reasoning approach is introduced to make up the deficiencies of the existing expert-system approach to the process design, from which a computational system for process design of injection moulding, named CSPD, was developed and described. CSPD first derives the process solution including the selection of injection moulding machine and mould base, tooling cost, and processing cost estimation, and production scheduling based on the blackboard-based expert-system approach. It is then followed by the determination of the injection moulding parameters based on the case-based reasoning approach and the previously derived partial solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01199878
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructure of cleavage stages and preimplantation embryos of the baboon (1974)
    Springer
    Anatomy and embryology 147 (1974), S. 45-62 
    Details
    ISSN: 1432-0568
    Keywords: Baboon ; Cleavage stages ; Embryos ; Preimplantation ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La structure et l'ultrastructure des embryons de babouin sont étudiées dans la période précédant l'implantation. Six stades du développement embryonnaire sont observés 2, 3, 4, 5, 7 et 8 jours après la date présumée de fécondation. Dans les 3 premiers cas, on compte respectivement 2, 8 et 24 blastoméres. A 5 jours, il y a 30 à 40 cellules et un nombre dépassant 60, ultérieurement. Des cellules trophoblastiques primitives se différencient à 7 jours et une cavité de segmentation en forme de croissant apparaît au 8 ème jour. La zone pellucide est toujours présente à 8 jours, la période de préimplantation semblant plus longue chez le babouin que chez l'homme. Des particules de type C sont décrites dans la zone pellucide et les espaces périvitellin et interblastomériques. La transformation des mitochondries, des changements dans la répartition des ribosomes, des corps multivésiculaires, pseudocristallins et figures myéliniques, des nucléoles et amas granuleux intra-nucléaires s'observent chez le babouin comme chez certains autres Mammifères; par contre, les faisceaux fibrillaires cytoplasmiques sont absents. L'étude des changements de l'ultrastructure provoqués par des hormones et drogues permettrait de mieux évaluer la nocivité de ces substances pendant les premiers stades du développement embryonnaire des Primates.
    Notes: Summary The baboon preimplantation stages were examined using light and electron microscopy. Six cases were studied at 2, 3, 4, 5, 7 and 8 days estimated fertilization age. The first 3 specimens were composed of 2, 8 and 24 blastomeres respectively. At 5 days, 30 to 40 cells were counted and more than 60 cells in later stages. Primitive “trophoblast cells” differentiate at 7 days and a crescentic blastocoele appears at 8 days. Shedding of the zona pellucida is not observed in the 7 and 8 day specimens. The preimplantation period is longer in the baboon than in man. C-type viruses are observed in the zona pellucida, in the perivitelline and interblastomeric spaces. Microvilli and caveolae cover the periphery of the baboon conceptus. As in many other mammals, transformation of the mitochondria, changes in the ribosomes distribution, multivesicular bodies, myelin figures, nucleoli and intranuclear clusters of granules are described in the baboon. Cytoplasmic fibrous strands are not present as in the mouse. Experiments on the influence of hormones and drugs on ultrastructural changes would help to evaluate the importance of biohazards during the early development of primates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00317963
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrastructural and fluorescence histochemical studies on the effects of 6-hydroxydopamine on the rat median eminence (1974)
    Springer
    Cell & tissue research 152 (1974), S. 493-512 
    Details
    ISSN: 1432-0878
    Keywords: Median eminence ; 6-Hydroxydopamine ; Fluorescence ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The extent of degeneration and regeneration of catecholamine-containing nerve fibres in the external layer of the median eminence of the rat has been assessed following treatment with 6-OHDA. Ultrastructural and fluorescence histochemical evidence suggests that nerve terminal degeneration occurs in the external layer of the caudal regions of the median eminence, including the anatomical stem, following intravenous injection of 6-OHDA in a dose of 100 mg/kg. No degeneration in the external layer of the median eminence was observed when the drug was given as sequential intracisternal injections to adult rats or neonatal rats by subcutaneous injections. The fluorescence histochemical studies suggest that regeneration of catecholamine-containing neurons is substantially complete within three weeks of treatment with intravenous 6-OHDA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218934
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  • 5
    Electronic Resource
    Electronic Resource
    The neurosecretory cells of the optic lobe in Carcinus maenas (L) (1975)
    Springer
    Cell & tissue research 156 (1975), S. 403-409 
    Details
    ISSN: 1432-0878
    Keywords: Neurosecretory cells ; Eyestalk ; Carcinus ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The six types of neurosecretory cell in the optic lobe of Carcinus maenas described by light microscopy are recognised by electron microscopy. They are categorised according to size, distribution of organelles and type of neurosecretory product. The neuro secretory material, produced as granules by the Golgi bodies, migrates to the cell periphery eventually reaching the sinus gland via the neurosecretory cell axon extension. No change in size occurs in the granules but the density does alter. Each cell type has its own characteristic type of neurosecretory granule based on size and electron density. Multivesicular and lytic bodies in cell types 1, 2, 3,4 and 6 suggest a cycle for degrading neurosecretory material. Such a cycle is not so evident in cell type 5. Peripheral release of neurosecretory material is suggested for cell type 6 although the fate of the material is unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225368
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Ultrastructural features of the developing hypothalamo-hypophysial axis in the rat (1971)
    Springer
    Cell & tissue research 119 (1971), S. 208-226 
    Details
    ISSN: 1432-0878
    Keywords: Median eminence ; Hypophysial portal vessels ; Pars distalis ; Ultrastructure ; Development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Nerve fibres containing granular vesicles first appear in the median eminence of the rat on the 16th foetal day while secretory granules in the cells of the adenohypophysis are not present till the 17th foetal day. These observations suggest that the differentiation and early activity of pars distalis cells may depend on substances elaborated at nerve terminals in the median eminence. Although the loops of the primary plexus of portal vessels do not develop until the 4th postnatal day, substances released by nerve fibres in the neurohypophysis could reach the pars distalis through vessels already present at the 15th foetal day in the mesenchyme between the diencephalon and the adenohypophysis. This view is supported by the fact that the earliest cells to exhibit ultrastructural evidence of secretory activity are in the rostral pole of the pars distalis, the first region of the gland to become vascularized. The earliest granules to appear in the cells of the pars distalis correspond to those which are considered to contain mucoprotein hormones; somatotrophin type granules were seen only in postnatal tissues. The finding that, in the median eminence, the development of granular vesicles precedes that of agranular vesicles is discussed with reference to the times at which neurosecretory materials and monoamines become detectable in the region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00324522
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    Paper (German National Licenses)
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