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  • 1
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; insulin-dependent ; glucose recycling ; glucose ; insulin ; Cori cycle ; isotopes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Six Type 1 (insulin-dependent) diabetic subjects were studied in order to determine the contribution of recycling of glucose carbon to the overproduction of glucose which is characteristic of the fasting hyperglycaemia produced by insulin withdrawal. The subjects were studied on two occasions, once after an overnight insulin infusion and once following 24 h of insulin withdrawal. The difference in turnover rates of 1-14C-glucose and 3-3H-glucose was used as a measure of glucose recycling. Insulin withdrawal caused a marked metabolic derangement with a rise in non-esterified fatty acids from 0.69±0.23 to 1.11±0.21 mmol/l (mean±SEM, p〈0.05), total ketones from 0.27±0.06 to 2.06±0.51 mmol/l (p〈0.01), cortisol from 341±43 to 479±31 nmol/l (p〈0.05) and growth hormone from 1.1±0.3 to 19+5-mu/l (p〈0.05). Glucose turnover rose from 13.8±2.3 μmol·kg−1·min−1 at a glucose of 6.9±0.7 mmol/l in the insulin infused study to 25.8±4.4 μmol·kg−1·min−1 (p〈0.05) at a glucose of 16.4±0.7 mmol/l in the insulin withdrawn study. Recycling also rose from 3.0±0.4 μmol· kg−1·min−1 to 9.4±2.2 μmol·kg−1·min−1 (p〈0.05) when insulin withdrawn, accounting for 23±3% and 36±3% of glucose turnover, respectively. We conclude that in the severely insulin deficient Type 1 diabetic subject recycling of glucose carbon is a major contributor to the excess glucose production.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 50 (1982), S. 169-174 
    ISSN: 1432-1246
    Keywords: Noise level ; Blood pressure ; Heart rate ; Chronic noise exposure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Physiological parameters have been compared in 75 normal healthy individuals exposed to occupational noise of 88–107 dB (A) (6–8h/day) for 10–15 years and in 36 normal non-exposed subjects. Blood pressure, both systolic (P〈0.01) and diastolic (P〈0.001), and heart rate (P〈0.05) were found to be significantly higher in the exposed subjects. Irregularity in cardiac rhythm, both in amplitude and duration, was found in 18% of the exposed subjects as against 6% in the non-exposed group. Variation in the heart rate during acute noise exposure of 90 dB (A) has been shown to be related with the preponderance of tonicity of sympathetics and parasympathetics. Measurement of hand blood flow during the same exposure showed a lesser degree of vasoconstriction and a slower recovery rate in the exposed group. Altered observations in the exposed group could be attributed to changes in the mechanical property of blood vessels.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-5036
    Keywords: Azospirillum brasilense ; chemotaxis ; Eleusine coracana ; nitrogenase activity ; root exudates ; salt tolerant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Three salt-tolerantAzospirillum brasilense strains were isolated from the roots of finger millet grown in saline calcareous soil and characterized. The effect of various salts on growth and N2ase activity of these strains was tested and strain STR1 was found more tolerant at higher concentrations of Cl-, SO4 2 and HCO3 -. Bicarbonate was found to be the most toxic. The content and concentrations of root exudates of finger millet genotypes were different and chemotaxis to sugars, amino acids, organic acids and root exudates was strain specific. Under salt stress, significant interactions between strains and genotypes of finger millet resulted in different responses of N2ase activity, endo- and exorhizospheric population, dry weight of root, shoot and grain yield.
    Type of Medium: Electronic Resource
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